Results 11 to 20 of about 231,978 (311)
Anabolic effects of IGF-1 signaling on the skeleton [PDF]
Frontiers in Endocrinology, 2013 This review focuses on the anabolic effects of IGF-1 signaling on the skeleton, emphasizing the requirement for IGF-1 signaling in normal bone formation and remodeling.
Candice G. T Tahimic +5 more
doaj +4 more sources
IGF-1 regulates Cyr61 induced breast cancer cell proliferation and invasion. [PDF]
, 2014 BackgroundStudies from our laboratory and others have shown that cysteine-rich 61 (Cyr61) may be involved in tumor proliferation and invasion. In earlier studies, we demonstrated increased insulin-like growth factor-I (IGF-1) is associated with breast ...
Cardenas, Jessica +5 more
core +16 more sources
Increased circulating insulin-like growth factor-1 in late-onset Alzheimer's disease [PDF]
, 2007 Background: Insulin-like growth factor (IGF)-1 has been implicated in the pathogenesis of Alzheimer's disease ( AD). Methods: We compared the level of circulating total and bioavailable IGF-1, by simultaneous measurements of IGF-1 and IGF binding ...
Bowie, P.C.W +5 more
core +1 more source
Aging, Atherosclerosis, and IGF-1 [PDF]
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 2012 Insulin-like growth factor 1 (IGF-1) is an endocrine and autocrine/paracrine growth factor that circulates at high levels in the plasma and is expressed in most cell types. IGF-1 has major effects on development, cell growth and differentiation, and tissue repair. Recent evidence indicates that IGF-1 reduces atherosclerosis burden and improves features
Yusuke, Higashi +4 more
openaire +2 more sources
Insulin-like growth factor-1 is a negative modulator of glucagon secretion [PDF]
, 2017 Glucagon secretion involves a combination of paracrine, autocrine, hormonal, and autonomic neural mechanisms. Type 2 diabetes often presents impaired glucagon suppression by insulin and glucose.
Andreozzi, F +6 more
core +1 more source
Insulin-Like Growth Factor-1 (IGF-1) and Its Monitoring in Medical Diagnostic and in Sports
Biomolecules, 2021 Insulin-like growth factor-1 (IGF-1) is the principal mediator of growth hormone (GH), plays a crucial role in promoting cell growth and differentiation in childhood and continues to have an anabolic effect in adults.
Julian Bailes, Mikhail Soloviev
doaj +1 more source
Functional muscle hypertrophy by increased insulin-like growth factor 1 does not require dysferlin. [PDF]
, 2019 IntroductionDysferlin loss-of-function mutations cause muscular dystrophy, accompanied by impaired membrane repair and muscle weakness. Growth promoting strategies including insulin-like growth factor 1 (IGF-1) could provide benefit but may cause ...
Barton, Elisabeth R +9 more
core +1 more source
Molecules, 2023 Insulin-like growth factor-1 (IGF-1) function declines with age and is associated with brain ageing and the progression of age-related neurological conditions.
Jian Guan +7 more
doaj +1 more source
Insulin-like Growth Factor 1 and Transforming Growth Factor-β Stimulate Cystine/Glutamate Exchange Activity in Dental Pulp Cells [PDF]
, 2011 Introduction The growth factors insulin-like growth factor (IGF-1) and transforming growth factor-β (TGF-β) are protective to dental pulp cells in culture against the toxicity of the composite materials Durafill VS and Flow Line (Henry Schein Inc, New ...
Alyssa Furey +39 more
core +2 more sources
Kidney & Blood Pressure Research, 2017 Background/Aim: Glomerulonephritis due to mesangial proliferation is responsible for renal dysfunction in IgA nephropathy (IgAN), however molecular mechanisms of pathogenesis are not well known. We examined the effect of IgA on Insulin-like Growth Factor-
Amal Al-Eisa, Gursev S. Dhaunsi
doaj +1 more source