Results 41 to 50 of about 107,691,036 (255)

Correlation between IGF-2 and IGF-1 levels in type 1 diabetic Iraqi patients

Сахарный диабет
BACKGROUND: Type 1 diabetes mellitus (T1D) is an autoimmune disorder characterized by impaired β-cell function and insulin deficiency, with emerging evidence implicating dysregulation of the insulin-like growth factor (IGF) axis in its pathophysiology ...
E. M. Eltayef, K. Gharab, L. A. Ghannawi, S. E. Atta, I. N. Salman   +4 more
doaj   +1 more source

Correlation of tri-ponderal mass index with insulin-like growth factor-I and insulin-like growth factor binding protein-3 in children and adolescents [PDF]

Annals of Pediatric Endocrinology & Metabolism
Purpose We aimed to investigate the relationship between the tri-ponderal mass index (TMI), a new indirect measure of fat mass, and insulin-like growth factor (IGF)-I/IGF binding protein (IGFBP)-3.
Iee Ho Choi, Sun-Young Kim, Minsun Kim
doaj   +1 more source

Administration of bovine anti-IGF-1 immunoglobulin to dietary protein deficient rats alters dietary intake and plasma IGF-1 binding profiles, but does not affect change in body mass

Animal, 2010
The potential of antibodies raised against insulin-like growth factor-1 (IGF-1) as a treatment to enhance the anabolic actions of IGF-1 has been demonstrated in both rodent and ruminant models. We investigated whether treatment of genetically normal rats
N.N. Smith, M.J. Kelly, J.M. Pell, R.A. Hill   +3 more
doaj   +1 more source

Low Insulin-Like Growth Factor-1 Level in Obesity Nephropathy: A New Risk Factor? [PDF]

PLoS ONE, 2016
INTRODUCTION:IGF-1 (insulin-like growth factor-1) is a hormone involved in cell growth and other important processes. In the kidney, IGF-1 has a stimulating effect, increasing the blood flow and glomerular filtration rate.
Ioana Bancu, Maruja Navarro Díaz, Assumpta Serra, Marisa Granada, Dolores Lopez, Ramon Romero, Josep Bonet   +6 more
doaj   +1 more source

Re-expression of IGF-II is important for beta cell regeneration in adult mice [PDF]

, 2012
Background The key factors which support re-expansion of beta cell numbers after injury are largely unknown. Insulin-like growth factor II (IGF-II) plays a critical role in supporting cell division and differentiation during ontogeny but its role in the
Nattkemper, Tim Wilhelm ; https://orcid.org/, Zhou Luxian, Abouna, Sylvie, Julia Herold (136338), James Young (44149), Nattkemper Tim Wilhelm, Abouna Sylvie, Nakhai Hassan, Epstein David, Tim Wilhelm Nattkemper, Herold Julia, Pelengaris Stella, Young, James, Khan, Michael, Stella Pelengaris, Herold, Julia, Nakhai, Hassan, Stella Pelengaris (71018), Hassan Nakhai (136340), Pelengaris, Stella, Sylvie Abouna (71019), Zhou, Luxian, Young James, Luxian Zhou, Michael Khan, Michael Khan (71023), Epstein, David, David Epstein, Luxian Zhou (136331), Hassan Nakhai, Khan Michael, Sylvie Abouna, Epstein, D. B. A., James Young, Nattkemper, Tim W., David Epstein (136335), Tim Wilhelm Nattkemper (136339), Julia Herold   +37 more
core   +2 more sources

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Elevated levels of IL-6 and IGFBP-1 predict low serum IGF-1 levels during continuous infusion of rhIGF-1/rhIGFBP-3 in extremely preterm infants

, 2020
Objective: Steady state insulin-like growth factor-1 (IGF-1) levels vary significantly during continuous intravenous infusion of recombinant human insulin-like growth factor-1/recombinant human insulin-like growth factor binding protein-3 (rhIGF-1 ...
Hellström, Ann,, Klevebro, Susanna, Pivodic, Aldina, Wackernagel, Dirk, Ley, David,, Hansen-Pupp, Ingrid, Smith, Lois,, Hallberg, Boubou, Borg, Jan, Smith, Lois, Klevebro, Susanna,, Hellgren, Gunnel,, Hellgren, Gunnel, Wackernagel, Dirk,, Ley, David, Borg, Jan,, Hallberg, Boubou,, Pivodic, Aldina,, Hansen-Pupp, Ingrid,, Hellström, Ann, Lund University., Klevebro, S., Pivodic, A., Smith, L., Klevebro, S,, Wackernagel, D,, Wackernagel, D., Hansen-Pupp, I, Borg, J, Borg, J., Hellgren, G, Pivodic, A, Smith, L, Hallberg, B,, Ley, D, Hellstrom, A, Ley, D., Hallberg, B., Hansen-Pupp, I.   +38 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Association between insulin‐like growth factor‐1 and systolic blood pressure in children and adolescents with short stature

The Journal of Clinical Hypertension, 2021
The relationship between insulin‐like growth factor‐1 (IGF‐1) and systolic blood pressure (SBP) is controversial in adults and children. The purpose of this study was to investigate the relationship between the IGF‐1 standard deviation score (IGF‐1 SDS ...
Qianqian Zhao, Mei Zhang, Yuntian Chu, Hailing Sun, Bo Ban   +4 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source