Insulin receptor Arg717 and IGF-1 receptor Arg704 play a key role in ligand binding and in receptor activation [PDF]
Open Biology, 2023 The insulin receptor (IR, with its isoforms IR-A and IR-B) and the insulin-like growth factor 1 receptor (IGF-1R) are related tyrosine kinase receptors.
Anna Kertisová +7 more
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Research Note: Expression of IGF-1 and IGF-1 receptor proteins in skeletal muscle fiber types in chickens with hepatic fibrosis [PDF]
Poultry Science, 2022 : We investigated the expression of insulin-like growth factor 1 (IGF-1) and IGF-1 type 1 receptor (IGF-1R) in skeletal muscle fiber types in chickens with hepatic fibrosis induced by bile duct ligation (BDL).
J. Nagasao +11 more
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A viral insulin-like peptide inhibits IGF-1 receptor phosphorylation and regulates IGF1R gene expression [PDF]
Molecular MetabolismObjective: The insulin/IGF superfamily is conserved across vertebrates and invertebrates. Our team has identified five viruses containing genes encoding viral insulin/IGF-1 like peptides (VILPs) closely resembling human insulin and IGF-1. This study aims
Martina Chrudinová +13 more
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A viral insulin-like peptide is a natural competitive antagonist of the human IGF-1 receptor [PDF]
Molecular Metabolism, 2021 Objective: Natural sources of molecular diversity remain of utmost importance as a reservoir of proteins and peptides with unique biological functions. We recently identified such a family of viral insulin-like peptides (VILPs).
Fa Zhang +4 more
doaj +2 more sources
IGF-IR internalizes with Caveolin-1 and PTRF/Cavin in HaCat cells. [PDF]
PLoS ONE, 2010 BACKGROUND:Insulin-like growth factor-I receptor (IGF-IR) is a tyrosine kinase receptor (RTK) associated with caveolae, invaginations of the plasma membrane that regulate vesicular transport, endocytosis and intracellular signaling.
Barbara Salani +7 more
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Pan-Cancer Analysis of IGF-1 and IGF-1R as Potential Prognostic Biomarkers and Immunotherapy Targets
Frontiers in Oncology, 2021 AimInsulin-like growth factor-1 receptor (IGF-1R) is one of the main members of the tyrosine protein kinase receptor family. This receptor binds insulin-like growth factor-1 (IGF-1) with a high affinity. IGF-1 is a member of a family of proteins involved
Yinqi Zhang +17 more
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Role of ubiquitination in IGF-1 receptor signaling and degradation. [PDF]
PLoS ONE, 2007 BACKGROUND: The insulin-like growth factor 1 receptor (IGF-1R) plays numerous crucial roles in cancer biology. The majority of knowledge on IGF-1R signaling is concerned with its role in the activation of the canonical phosphatidyl inositol-3 kinase ...
Bita Sehat +4 more
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Pharmaceuticals, 2023 Pediatric high-grade gliomas (pHGG) accounts for approximately 8–12% of primary brain tumors in children. Prognosis is poor, with a median survival of 9–15 months. Insulin-like growth factor 1-receptor (IGF-1R) gene amplifications have been identified in
Yinhsuan Michely Chen +4 more
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The Insulin/IGF system in colorectal cancer development and resistance to therapy
Frontiers in Oncology, 2015 The Insulin/Insulin-like growth factor (IGF) system is a major determinant in the pathogenesis and progression of colorectal cancer (CRC). Indeed, several components of this signaling network including Insulin, IGF-1, IGF-2, the IGF-Binding Proteins, the
Paolo Giovanni Vigneri +6 more
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Journal of Pharmacological Sciences, 2009 We previously demonstrated that the growth hormone (GH)-releaser diet ameliorated β-amyloid (Aβ) (1-42)–induced memory impairment, but the underlying mechanism remained to be characterized.
Eun-Joo Shin +7 more
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