Results 21 to 30 of about 30,609,190 (316)

Effect Of IGF-1 On Expression Of Gh Receptor, IGF-1, IGF-1 Receptor, KAP3.2 And KAP6-1 MRNA In The Skin Of Sheep

International Journal of Biology, 2009
Thirty-six healthy and similar Chinese Merino sheep were selected and divided into six groups at random. The treatment group was injected intradermally with 0.5 mL IGF-1 (10ng/mL). Treatment skin tissue of sheep were sampled respectively for 0,3,6,9,12 and 50 days and the skin expression of growth hormone receptor (GHR), insulin-like growth factor1 ...
Cheng-xian, Z, He-rong, L, Yan, Z
core   +5 more sources

Distinct, common and synergistic effects of insulin and IGF-1 receptors on healthy murine ageing

Heliyon
Objective: Reduced IGF-1 signalling is an evolutionarily conserved mediator of longevity, yet the magnitude of this effect is substantially larger in organisms retaining a common insulin and IGF-1 receptor.
Andrew MN Walker, Nicole T. Watt, Nadira Y. Yuldasheva, Sanjush Dalmia, Marcella Conning-Rowland, Chew W. Cheng, Nele Warmke, Katherine Bridge, Oliver I. Brown, Cheukyau Luk, Michael Drozd, Natalie J. Haywood, Anna Skromna, Natasha Makava, Stephen B. Wheatcroft, Mark T. Kearney, Richard M. Cubbon   +16 more
doaj   +2 more sources

Preclinical pharmacology, pharmacokinetics, and pharmacodynamics of veligrotug, a full antagonist antibody to the IGF-1 receptor in development for thyroid eye disease. [PDF]

MAbs
Kaplan R, Zhao Y, Tsai J, Dickinson B, Swanson T, Foster K, Bedian V.   +6 more
europepmc   +2 more sources

Viral insulin/IGF-like peptides inhibit IGF-1 receptor signaling to enhance viral replication. [PDF]

Cell Rep
Chuard A, Nesarajah K, Danazumi K, Reiners K, Zhang F, Levintov L, Lubos M, Žáková L, Ruggera R, McMenamin S, Vashisth H, Jiráček J, Dimarchi R, Altindis E.   +13 more
europepmc   +3 more sources

Picropodophyllin, an IGF‑1 receptor inhibitor, enhances oxaliplatin efficacy in chemoresistant colorectal cancer HCT116 cells by reducing metastatic potential. [PDF]

Oncol Lett
Kayacik N, Kurter H, Sever T, Basbinar Y, Calibasi-Kocal G.   +4 more
europepmc   +3 more sources

Expression of Concern: Role of Ubiquitination in IGF-1 Receptor Signaling and Degradation. [PDF]

PLoS One
PLOS One Editors.
europepmc   +3 more sources

6461 VRDN-003, A Full Antagonist Antibody To The IGF-1 Receptor For Thyroid Eye Disease (TED): Safety And Pharmacokinetic Results Of Subcutaneous Administration In Healthy Volunteers [PDF]

J Endocr Soc
Kelly Foster, Brent Dickinson, Abiola Matthew, Jyothi Vijayaraghavan, Cathy Michalsky, Vahe Bedian   +5 more
europepmc   +5 more sources

Paracrine role of endothelial IGF-1 receptor in depot-specific adipose tissue adaptation in male mice. [PDF]

Nat Commun
Luk C, Bridge KI, Warmke N, Simmons KJ, Drozd M, Moran A, MacCannell ADV, Cheng CW, Straw S, Scragg JL, Smith J, Ozber CH, Wilkinson CG, Skromna A, Makava N, Prag HA, Simon Futers T, Brown OI, Bruns AF, Walker AM, Watt NT, Mughal R, Griffin KJ, Yuldasheva NY, Limumpornpetch S, Viswambharan H, Sukumar P, Beech DJ, Vidal-Puig A, Witte KK, Murphy MP, Hartley RC, Wheatcroft SB, Cubbon RM, Roberts LD, Kearney MT, Haywood NJ.   +36 more
europepmc   +3 more sources

Mechanisms in Thyroid Eye Disease: The TSH Receptor Interacts Directly With the IGF-1 Receptor.

Endocrinology
Latif R, Mezei M, Davies TF.
europepmc   +3 more sources

Developmental disruption of the mitochondrial fission gene drp-1 extends the longevity of daf-2 insulin/IGF-1 receptor mutant. [PDF]

Geroscience
Traa A, Tamez González AA, Van Raamsdonk JM.   +2 more
europepmc   +4 more sources