IGF-1 receptor cleavage in hypertension. [PDF]
Hypertens Res, 2018 Increased protease activity causes receptor dysfunction due to extracellular cleavage of different membrane receptors in hypertension. The vasodilatory effects of insulin-like growth factor-1 (IGF-1) are decreased in hypertension. Therefore, in the present study the association of an enhanced protease activity and IGF-1 receptor cleavage was ...
Cirrik S, Schmid-Schönbein GW.
europepmc +9 more sources
A viral insulin-like peptide inhibits IGF-1 receptor phosphorylation and regulates IGF1R gene expression [PDF]
Molecular MetabolismObjective: The insulin/IGF superfamily is conserved across vertebrates and invertebrates. Our team has identified five viruses containing genes encoding viral insulin/IGF-1 like peptides (VILPs) closely resembling human insulin and IGF-1. This study aims
Martina Chrudinová +13 more
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Insulin receptor Arg717 and IGF-1 receptor Arg704 play a key role in ligand binding and in receptor activation [PDF]
Open Biology, 2023 The insulin receptor (IR, with its isoforms IR-A and IR-B) and the insulin-like growth factor 1 receptor (IGF-1R) are related tyrosine kinase receptors.
Anna Kertisová +7 more
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Fluconazole Is Neuroprotective via Interactions with the IGF-1 Receptor. [PDF]
Neurotherapeutics, 2022 There is a continuing unmet medical need to develop neuroprotective strategies to treat neurodegenerative disorders. To address this need, we screened over 2000 compounds for potential neuroprotective activity in a model of oxidative stress and found that numerous antifungal agents were neuroprotective.
Toodle V +9 more
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How IGF-1 activates its receptor
eLife, 2014 The type I insulin-like growth factor receptor (IGF1R) is involved in growth and survival of normal and neoplastic cells. A ligand-dependent conformational change is thought to regulate IGF1R activity, but the nature of this change is unclear.
Jennifer M Kavran +11 more
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Research Note: Expression of IGF-1 and IGF-1 receptor proteins in skeletal muscle fiber types in chickens with hepatic fibrosis [PDF]
Poultry Science, 2022 : We investigated the expression of insulin-like growth factor 1 (IGF-1) and IGF-1 type 1 receptor (IGF-1R) in skeletal muscle fiber types in chickens with hepatic fibrosis induced by bile duct ligation (BDL).
J. Nagasao +11 more
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Role of ubiquitination in IGF-1 receptor signaling and degradation. [PDF]
PLoS ONE, 2007 BACKGROUND: The insulin-like growth factor 1 receptor (IGF-1R) plays numerous crucial roles in cancer biology. The majority of knowledge on IGF-1R signaling is concerned with its role in the activation of the canonical phosphatidyl inositol-3 kinase ...
Bita Sehat +4 more
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A viral insulin-like peptide is a natural competitive antagonist of the human IGF-1 receptor [PDF]
Molecular Metabolism, 2021 Objective: Natural sources of molecular diversity remain of utmost importance as a reservoir of proteins and peptides with unique biological functions. We recently identified such a family of viral insulin-like peptides (VILPs).
Fa Zhang +4 more
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An engineered insulin analog with dual insulin and IGF-1 receptor agonism and distinct signaling. [PDF]
Sci AdvSelicharová I +13 more
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Extending IGF-1 Receptor Inhibition Beyond Thyroid Eye Disease: A Scoping Review of Teprotumumab Administration in Pretibial Myxedema. [PDF]
AACE Endocrinol DiabetesLevy Barnett MJ +2 more
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