Results 31 to 40 of about 30,609,190 (316)

6580 Inhibition of IGF-1 Receptor Signaling and Ocular Fibroblast Cell Growth by VRDN-001 vs Teprotumumab [PDF]

J Endocr Soc
Rachel Newell, Tricia Nguyen, Vahe Bedian   +2 more
europepmc   +3 more sources

6509 IGF-1 receptor and insulin receptor in LepRb neurons coordinates body growth, reproduction, and metabolism [PDF]

J Endocr Soc
Mengjie Wang, Jennifer W. Hill
europepmc   +3 more sources

Regulation of human fibroblast insulin-like growth factor (IGF)-binding proteins by IGF-1 and cytokines, mechanisms of action and effects upon IGF bioactivity [PDF]

, 1995
PhDThe insulin-like growth factors, IGF-I and IGF-II, are ubiquitous polypeptide molecules that have mitogenic and metabolic actions in a wide variety of cell types, and consequently play a major role in mammalian growth and development.
Yateman, Martin Edward
core   +4 more sources

Cumulative mutagenesis of the basic residues in the 201-218 region of insulin-like growth factor (IGF)-binding protein-5 results in progressive loss of both IGF-I binding and inhibition of IGF-I biological action [PDF]

, 2005
We have reported previously that mutation of two conserved nonbasic amino acids (G203 and Q209) within the highly basic 201–218 region in the C-terminal domain of IGF-binding protein-5 (IGFBP-5) decreases binding to IGFs.
Clegg, R.A., Kelly, S.M., Allan, G.J., Flint, D.J., Shand, J., Beattie, J., Gow, I.F., Tonner, E., Szymanowska, M., Phillips, K.   +9 more
core   +4 more sources

The GH-IGF-I axis and breast cancer [PDF]

, 2012
MD (Res)Breast cancer remains one of the most common causes of death amongst women today. Worldwide approximately 1.3 million women are diagnosed as having breast cancer every year.
Laban, Christiana
core   +4 more sources

Early IGF-1 receptor inhibition in mice mimics preterm human brain disorders and reveals a therapeutic target. [PDF]

Sci Adv
Potenzieri A, Uccella S, Preiti D, Pisoni M, Rosati S, Lavarello C, Bartolucci M, Debellis D, Catalano F, Petretto A, Nobili L, Fellin T, Tucci V, Ramenghi LA, Savardi A, Cancedda L.   +15 more
europepmc   +2 more sources

IGF-IR internalizes with Caveolin-1 and PTRF/Cavin in HaCat cells. [PDF]

PLoS ONE, 2010
BACKGROUND:Insulin-like growth factor-I receptor (IGF-IR) is a tyrosine kinase receptor (RTK) associated with caveolae, invaginations of the plasma membrane that regulate vesicular transport, endocytosis and intracellular signaling.
Barbara Salani, Mario Passalacqua, Sara Maffioli, Lucia Briatore, Meriem Hamoudane, Paola Contini, Renzo Cordera, Davide Maggi   +7 more
doaj   +1 more source

IGF-1 receptor antagonism inhibits autophagy [PDF]

Human Molecular Genetics, 2013
Inhibition of the insulin/insulin-like growth factor signalling pathway increases lifespan and protects against neurodegeneration in model organisms, and has been considered as a potential therapeutic target. This pathway is upstream of mTORC1, a negative regulator of autophagy.
Renna, Maurizio, Bento, Carla F., Fleming, Angeleen, Menzies, Fiona M., Siddiqi, Farah H., Ravikumar, Brinda, Puri, Claudia, Garcia-Arencibia, Moises, Sadiq, Oana, Corrochano, Silvia, Carter, Sarah, Brown, Steve D. M., Acevedo-Arozena, Abraham, Rubinsztein, David C.   +13 more
openaire   +5 more sources

Pan-Cancer Analysis of IGF-1 and IGF-1R as Potential Prognostic Biomarkers and Immunotherapy Targets

Frontiers in Oncology, 2021
AimInsulin-like growth factor-1 receptor (IGF-1R) is one of the main members of the tyrosine protein kinase receptor family. This receptor binds insulin-like growth factor-1 (IGF-1) with a high affinity. IGF-1 is a member of a family of proteins involved
Yinqi Zhang, Yinqi Zhang, Chengqi Gao, Fei Cao, Fei Cao, Ying Wu, Ying Wu, Shuanggang Chen, Xue Han, Xue Han, Jingqin Mo, Zhiyu Qiu, Zhiyu Qiu, Weijun Fan, Weijun Fan, Penghui Zhou, Lujun Shen, Lujun Shen   +17 more
doaj   +1 more source

Targeting the IGF-Axis in Cultured Pediatric High-Grade Glioma Cells Inhibits Cell Cycle Progression and Survival

Pharmaceuticals, 2023
Pediatric high-grade gliomas (pHGG) accounts for approximately 8–12% of primary brain tumors in children. Prognosis is poor, with a median survival of 9–15 months. Insulin-like growth factor 1-receptor (IGF-1R) gene amplifications have been identified in
Yinhsuan Michely Chen, Matthew Leibovitch, Michele Zeinieh, Nada Jabado, Pnina Brodt   +4 more
doaj   +1 more source