How IGF-1 activates its receptor [PDF]
Journal of Cell Communication and Signaling, 2015 This study presents a new model for IGF-I receptor activation in which the transmembrane domains are held apart until ligand binding brings them together in an activated state.
openaire +2 more sources
Effects of In Ovo Vitamin D3 Injection on Subsequent Growth of Broilers
The Journal of Poultry Science, 2019 This study was conducted to investigate the influence of in ovo vitamin D3 (Vit D3) administration on growth of broiler chickens when Vit D3 was dissolved in soybean oil.
Takehiko Hayakawa +2 more
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Conditional VHL gene deletion causes hypoglycemic death associated with disproportionately increased glucose uptake by hepatocytes through an upregulated IGF-I receptor. [PDF]
PLoS ONE, 2013 Our conditional VHL knockout (VHL-KO) mice, having VHL gene deletion induced by tamoxifen, developed severe hypoglycemia associated with disproportionately increased storage of PAS-positive substances in the liver and resulted in the death of these mice.
Atsushi Kurabayashi +5 more
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Understanding the mechanism of insulin and insulin-like growth factor (IGF) receptor activation by IGF-II. [PDF]
PLoS ONE, 2011 BACKGROUND: Insulin-like growth factor-II (IGF-II) promotes cell proliferation and survival and plays an important role in normal fetal development and placental function.
Clair L Alvino +6 more
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Growth Hormone/Insulin Growth Factor Axis in Sex Steroid Associated Disorders and Related Cancers
Frontiers in Cell and Developmental Biology, 2021 To date, almost all solid malignancies have implicated insulin-like growth factor (IGF) signalling as a driver of tumour growth. However, the remarkable level of crosstalk between sex hormones, the IGF-1 receptor (IGF-1R) and its ligands IGF-1 and 2 in ...
Rachel Bleach +3 more
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IGF-1 receptor regulates dynamic changes in neuronal polarity during cerebral cortical migration
Scientific Reports, 2017 During cortical development, neurons undergo polarization, oriented migration and layer-type differentiation. The biological and biochemical mechanisms underlying these processes are not completely understood.
Alvaro F. Nieto Guil +6 more
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Activation of Akt by advanced glycation end products (AGEs): involvement of IGF-1 receptor and caveolin-1. [PDF]
PLoS ONE, 2013 Diabetes is characterized by chronic hyperglycemia, which in turn facilitates the formation of advanced glycation end products (AGEs). AGEs activate signaling proteins such as Src, Akt and ERK1/2.
Su-Jung Yang +7 more
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The Role of Insulin and Insulin-like Growth Factors in the Increased Risk of Cancer in Diabetes
Rambam Maimonides Medical Journal, 2011 Patients with type 2 diabetes (T2D) are at increased risk of developing cancer. This evidence arises from numerous epidemiologic studies that relate a positive association between T2D and cancer. In-vitro and several in-vivo experiments have attempted to
Derek LeRoith +2 more
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PLoS ONE, 2022 BackgroundIGF-1 is considered an important regulator of muscle protein synthesis. However, its role in stimulation of muscle protein synthesis by amino acids (AA) is not clear, despite pronounced alterations in IGF-1 mRNA expression and signaling in ...
Britt-Marie Iresjö +2 more
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IGF-1 receptor activity in the Golgi of migratory cancer cells depends on adhesion-dependent phosphorylation of Tyr1250 and Tyr1251 [PDF]
, 2020 Although insulin-like growth factor 1 (IGF-1) signaling promotes tumor growth and cancer progression, therapies that target the IGF-1 receptor (IGF-1R) have shown poor clinical efficacy.
Stanicka, Joanna +7 more
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