Results 61 to 70 of about 30,609,190 (316)

Insulin-like growth factor family and prostate cancer: new insights and emerging opportunities

Frontiers in Endocrinology
Prostate cancer is the second most commonly diagnosed cancer in men. The mammalian insulin-like growth factor (IGF) family is made up of three ligands (IGF-I, IGF-II, and insulin), three receptors (IGF-I receptor (IGF-1R), insulin receptor (IR), and IGF ...
Noha M. Elemam, Noha M. Elemam, Hassan Youssef Hotait, Mohamed A. Saleh, Mohamed A. Saleh, Mohamed A. Saleh, Waseem El-Huneidi, Waseem El-Huneidi, Iman M. Talaat, Iman M. Talaat, Iman M. Talaat   +10 more
doaj   +1 more source

IRS-1 acts as an endocytic regulator of IGF-I receptor to facilitate sustained IGF signaling

eLife, 2018
Insulin-like growth factor-I receptor (IGF-IR) preferentially regulates the long-term IGF activities including growth and metabolism. Kinetics of ligand-dependent IGF-IR endocytosis determines how IGF induces such downstream signaling outputs.
Yosuke Yoneyama, Peter Lanzerstorfer, Hideaki Niwa, Takashi Umehara, Takashi Shibano, Shigeyuki Yokoyama, Kazuhiro Chida, Julian Weghuber, Fumihiko Hakuno, Shin-Ichiro Takahashi   +9 more
doaj   +1 more source

Inhibition by Thyroid Hormones of Cell Migration Activated by IGF-1 and MCP-1 in THP-1 Monocytes: Focus on Signal Transduction Events Proximal to Integrin αvβ3

Frontiers in Cell and Developmental Biology, 2021
Interaction between thyroid hormones and the immune system is reported in the literature. Thyroid hormones, thyroxine, T4, but also T3, act non-genomically through mechanisms that involve a plasma membrane receptor αvβ3 integrin, a co-receptor for ...
Elena Candelotti, Roberto De Luca, Roberto Megna, Mariangela Maiolo, Paolo De Vito, Fabio Gionfra, Zulema Antonia Percario, Monica Borgatti, Roberto Gambari, Paul J. Davis, Paul J. Davis, Hung-Yun Lin, Hung-Yun Lin, Hung-Yun Lin, Hung-Yun Lin, Hung-Yun Lin, Fabio Polticelli, Tiziana Persichini, Marco Colasanti, Elisabetta Affabris, Jens Z. Pedersen, Sandra Incerpi   +21 more
doaj   +1 more source

Antidepressant-like effects of insulin and IGF-1 are mediated by IGF-1 receptors in the brain

Brain Research Bulletin, 2018
Depression is associated with uncontrolled diabetes, which indicates a lack of insulin effect, yet the role of the insulin receptor in mediating depression is not clearly established because insulin receptors are not required for glucose entry into the brain.
Paul L. Mueller, Carolyn E. Pritchett, Tyler N. Wiechman, Alevtina Zharikov, Andras Hajnal   +4 more
openaire   +2 more sources

The new kid on the block(ade) of the IGF-1 receptor [PDF]

Cancer Cell, 2004
The insulin-like growth factors (IGF) system, and particularly the IGF-1 receptor, has recently become the subject of major interest in the arena of cancer research. Its involvement in cancer cell growth and survival makes the system an excellent target as potential adjunct therapy to standard chemotherapy.
LeRoith, Derek, Helman, Lee
openaire   +3 more sources

Estrogen Receptor α Rapidly Activates the IGF-1 Receptor Pathway [PDF]

Journal of Biological Chemistry, 2000
Estrogen and insulin-like-growth factor 1 (IGF-1) are potent mitogenic stimuli that share important properties in the control of cellular proliferation. However, the coupling between the signaling cascades of estrogen receptors alpha and beta and the IGF-1 receptor (IGF-1R) is poorly understood.
S, Kahlert, S, Nuedling, M, van Eickels, H, Vetter, R, Meyer, C, Grohe   +5 more
openaire   +2 more sources

Molecular cloning of IGF-1 and IGF-1 receptor and their expression pattern in the Chilean flounder (Paralichthys adspersus) [PDF]

Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, 2011
Insulin-like growth factor-1 and insulin-like growth factor-1 receptor (IGF-1 and IGF-1R) play main roles in vertebrate growth and development. In fish, besides contributing to somatic growth, both molecules exhibit pleiotropic functions. We isolated complete cDNAs sequences encoding for both IGF-1 and IGF-1R in the Chilean flounder by using RT-PCR and
Escobar, Sebastian, Fuentes, Eduardo N., Poblete, Erika, Valdes, Juan A., Safian, Diego, Reyes, Ariel E., Alvarez, Marco, Molina, Alfredo   +7 more
openaire   +7 more sources

The role of receptor tyrosine kinase signalling in HER-2-positive cells and trastuzumab (Herceptin) resistance in breast cancer [PDF]

, 2009
HER-2 gene amplification or overexpression occurs in approximately 25 % of breast cancers, and trastuzumab (Tmab) is a monoclonal antibody currently used to treat patients with HER-2-overexpressing breast cancer.
Browne, Brigid
core   +2 more sources

Expression of IGF-1, IL-27 and IL-35 Receptors in Adjuvant Induced Rheumatoid Arthritis Model [PDF]

Iranian Journal of Immunology, 2018
Background: IGF-1 and certain other cytokines have been shown to exert inflammatory/anti-inflammatory roles in chronic joint diseases. Objective: To assess the effect of IGF-1, IL-27 and IL-35, their interaction and their receptor expression in a ...
Elham Abdi, Hamid Najafipour, Siyavash Joukar, Shahriar Dabiri, Saeed Esmaeli-Mahani, Elham Abbasloo, Nasrin Houshmandi, Abbas Afsharipour   +7 more
doaj  

LRP1 mediates the IGF-1-induced GLUT1 expression on the cell surface and glucose uptake in Müller glial cells

Scientific Reports, 2021
Insulin-like Growth Factor-1 (IGF-1) is involved in the normal development and survival of retinal cells. Low-density lipoprotein Receptor-related Protein-1 (LRP1) plays a key role on the regulation of several membrane proteins, such as the IGF-1 ...
Virginia Actis Dato, María Cecilia Sánchez, Gustavo Alberto Chiabrando   +2 more
doaj   +1 more source