Understanding IGF-II Action through Insights into Receptor Binding and Activation [PDF]
Cells, 2020 The insulin-like growth factor (IGF) system regulates metabolic and mitogenic signaling through an intricate network of related receptors and hormones. IGF-II is one of several hormones within this system that primarily regulates mitogenic functions and ...
Nicholas S Kirk, Briony E Forbes
exaly +5 more sources
IGF-II promotes neuroprotection and neuroplasticity recovery in a long-lasting model of oxidative damage induced by glucocorticoids [PDF]
Redox Biology, 2017 Insulin-like growth factor-II (IGF-II) is a naturally occurring hormone that exerts neurotrophic and neuroprotective properties in a wide range of neurodegenerative diseases and ageing.
E. Martín-Montañez +8 more
doaj +6 more sources
Autocrine IGF-II-Associated Cancers: From a Rare Paraneoplastic Event to a Hallmark in Malignancy [PDF]
Biomedicines, 2023 The paraneoplastic syndrome referred in the literature as non-islet-cell tumor hypoglycemia (NICTH) and extra-pancreatic tumor hypoglycemia (EPTH) was first reported almost a century ago, and the role of cancer-secreted IGF-II in causing this blood ...
Pierluigi Scalia +6 more
doaj +2 more sources
Determinants of IGF-II influencing stability, receptor binding and activation [PDF]
Scientific Reports, 2022 Insulin like growth factor II (IGF-II) is involved in metabolic and mitogenic signalling in mammalian cells and plays important roles in normal fetal development and postnatal growth.
Andrew Blyth +4 more
doaj +2 more sources
Re-expression of IGF-II is important for beta cell regeneration in adult mice. [PDF]
PLoS ONE, 2012 The key factors which support re-expansion of beta cell numbers after injury are largely unknown. Insulin-like growth factor II (IGF-II) plays a critical role in supporting cell division and differentiation during ontogeny but its role in the adult is ...
Luxian Zhou +8 more
doaj +9 more sources
The Neglected Insulin: IGF-II, a Metabolic Regulator with Implications for Diabetes, Obesity, and Cancer. [PDF]
Cells, 2019 When originally discovered, one of the initial observations was that, when all of the insulin peptide was depleted from serum, the vast majority of the insulin activity remained and this was due to a single additional peptide, IGF-II.
Holly JMP, Biernacka K, Perks CM.
europepmc +2 more sources
IGF-II Promotes Stemness of Neural Restricted Precursors [PDF]
Stem Cells, 2012 Abstract Insulin-like growth factor (IGF)-I and IGF-II regulate brain development and growth through the IGF type 1 receptor (IGF-1R). Less appreciated is that IGF-II, but not IGF-I, activates a splice variant of the insulin receptor (IR) known as IR-A.
Amber N, Ziegler +7 more
openaire +3 more sources
Fluorescent IGF-II analogues for FRET-based investigations into the binding of IGF-II to the IGF-1R [PDF]
Organic & Biomolecular Chemistry, 2016 This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material.The interaction of IGF-II ...
Abell, Andrew D +5 more
core +5 more sources
Insulin-like growth factor (IGF)-II- mediated fibrosis in pathogenic lung conditions. [PDF]
PLoS ONE, 2019 Type 2 insulin-like growth factor (IGF-II) levels are increased in fibrosing lung diseases such as idiopathic pulmonary fibrosis (IPF) and scleroderma/systemic sclerosis-associated pulmonary fibrosis (SSc). Our goal was to investigate the contribution of
Sara M Garrett +4 more
doaj +2 more sources
Understanding the mechanism of insulin and insulin-like growth factor (IGF) receptor activation by IGF-II. [PDF]
PLoS ONE, 2011 BACKGROUND: Insulin-like growth factor-II (IGF-II) promotes cell proliferation and survival and plays an important role in normal fetal development and placental function.
Clair L Alvino +6 more
doaj +2 more sources