Results 41 to 50 of about 5,200,432 (243)

Serum from Chronic Hepatitis B Patients Promotes Growth and Proliferation via the IGF-II/IGF-IR/MEK/ERK Signaling Pathway in Hepatocellular Carcinoma Cells

Cellular Physiology and Biochemistry, 2018
Background/Aims: Chronic hepatitis B virus (HBV) infection (CHB) plays a central role in the etiology of hepatocellular carcinoma (HCC). Emerging evidence implicates insulin-like growth factor (IGF)-II as a major risk factor for the growth and ...
Yuanyuan Ji, Zhidong Wang, Haiyan Chen, Lei Zhang, Fei Zhuo, Qingqing Yang   +5 more
doaj   +1 more source

IGF-I, IGF-II and insulin stimulate different gene expression responses through binding to the IGF-I receptor.

Frontiers in Endocrinology, 2013
Insulin and the insulin-like growth factors (IGF)-I and –II are closely related peptides important for regulation of metabolism, growth, differentiation and development. The IGFs exert their main effects through the IGF-I receptor.
Soetkin eVersteyhe, Birgit eKlaproth, Rehannah eBorup, Jane ePalsgaard, Maja eJensen, Steven G. Gray, Steven G. Gray, Pierre eDe Meyts   +7 more
doaj   +1 more source

Probing Receptor Specificity by Sampling the Conformational Space of the Insulin-like Growth Factor II C-domain [PDF]

, 2016
Insulin and insulin-like growth factors I and II are closely related protein hormones. Their distinct evolution has resulted in different yet overlapping biological functions with insulin becoming a key regulator of metabolism, whereas insulin-like ...
Collinsová, Michaela, Crump, Matthew P, Fábry, Milan, Hexnerová, Rozálie, Jiráček, Jiří, Kedrová, Kateřina, Křížková, Květoslava, Sieglová, Irena, Srb, Pavel, Tošner, Zdeněk, Ullrichová, Pavlína, Veverka, Václav, Williams, Christopher, Žáková, Lenka   +13 more
core   +2 more sources

CLINICAL IMPLICATIONS OF INSULIN-LIKE GROWTH FACTORS (IGF) AND IGF-BINDING PROTEINS INVESTIGATION IN PATIENTS WITH OVARIAN NEOPLASMS

Alʹmanah Kliničeskoj Mediciny, 2016
Background: The insulin-like growth factor (IGF) signaling system plays a major role in development and progression of various malignancies including ovarian cancer, and its components are considered as potential diagnostic and prognostic markers and the
E. S. Gershteyn, D. N. Kushlinskiy, E. A. Korotkova, E. R. Isaeva, V. D. Ermilova, K. P. Laktionov, L. V. Adamyan, N. E. Kushlinskii   +7 more
doaj   +1 more source

Comparative Effects of Insulin‐Like Growth Factor II (IGF‐II) and IGF‐II Mutants Specific for IGF‐II/CIM6‐P or IGF‐I Receptors on in Vitro Hematopoiesis [PDF]

STEM CELLS, 1996
This report presents the results of studies investigating the effect of insulin-like growth factor II (IGF-II) on the proliferation and differentiation of CD34+ bone marrow cells in serum-substituted liquid cultures. Bone marrow cells were enriched for CD34+ cells and then placed in liquid cultures supplemented with either interleukin 3 (IL-3) or IL-3 ...
G N, Schwartz, M K, Warren, K, Sakano, J M, Szabo, S W, Kessler, A, Pashapour, R E, Gress, J F, Perdue   +7 more
openaire   +2 more sources

Serine 204 phosphorylation and O-β-GlcNAC interplay of IGFBP-6 as therapeutic indicator to regulate IGF-II functions in viral mediated hepatocellular carcinoma

Virology Journal, 2011
Hepatocellular carcinoma is mainly associated with viral hepatitis B and C. Activation of cell growth stimulator IGF-II gene is observed in tumor formation especially in viral associated hepatocellular carcinoma.
Sarwar Muhammad T, Gull Sana, Kausar Humera, Fouzia Kiran, Nazar Shazia, Nazar Noreen, Asad Sultan, Ijaz Bushra, Shabbiri Khadija, Ahmad Waqar, Shahid Imaran, Hassan Sajida   +11 more
doaj   +1 more source

Role of Scaffold Protein Proline-, Glutamic Acid-, and Leucine-Rich Protein 1 (PELP1) in the Modulation of Adrenocortical Cancer Cell Growth [PDF]

, 2017
PELP1 acts as an estrogen receptor (ER) coactivator that exerts an essential role in the ER's functions. ER coregulators have a critical role in the progression and response to hormonal treatment of estrogen-dependent tumors.
Avena, Paola, Casaburi, Ivan, Chimento, Adele, De Luca, Arianna, Fallo, Francesco, Pezzi, Vincenzo, Pilon, Catia, Sirianni, Rosa   +7 more
core   +2 more sources

Refractory hypoglycemia in a patient with functional adrenal cortical carcinoma

Endocrinology, Diabetes & Metabolism Case Reports, 2016
Adrenacarcinomas are rare, and hypoglycemic syndrome resulting from the secretion of insulin-like growth factor II (IGF-II) by these tumors have been described infrequently.
Katia Regina Marchetti, Maria Adelaide Albergaria Pereira, Arnaldo Lichtenstein, Edison Ferreira Paiva   +3 more
doaj   +1 more source

Insulin-Like Growth Factor-II and Ischemic Stroke—A Prospective Observational Study

Life, 2021
Insulin-like growth factor-II (IGF-II) regulates prenatal brain development, but the role in adult brain function and injury is unclear. Here, we determined whether serum levels of IGF-II (s-IGF-II) are associated with mortality and functional outcome ...
Daniel Åberg, N. David Åberg, Katarina Jood, Petra Redfors, Christian Blomstrand, Jörgen Isgaard, Christina Jern, Johan Svensson   +7 more
doaj   +1 more source

Characteristics of Hepatic IGF-II Expression and Monitored Levels of Circulating IGF-II mRNA in Metastasis of Hepatocellular Carcinoma [PDF]

American Journal of Clinical Pathology, 2010
Abstract The prognosis of hepatocellular carcinoma (HCC) remains dismal. Insulin-like growth factor II (IGF-II), a fetal growth factor, is highly expressed during HCC development. We examined serum IGF-II levels and circulating IGF-II messenger RNA (mRNA) expression and analyzed the clinicopathologic characteristics in patients with ...
Jing, Qian, Dengfu, Yao, Zhizhen, Dong, Wei, Wu, Liwei, Qiu, Ninghua, Yao, Shanshan, Li, Yinzhu, Bian, Zhiwei, Wang, Gongsheng, Shi   +9 more
openaire   +2 more sources