Results 1 to 10 of about 18,925,600 (331)

Altered body composition and increased frequency of diverse malignancies in insulin-like growth factor-II transgenic mice.

Journal of Biological Chemistry, 1994
The physiological role of insulin-like growth factor (IGF) II (IGF-II) in adult humans is poorly understood. Rather high levels of IGF-II persist in adult human serum, whereas, in rodents, IGF-II levels are very low.
C. Rogler, De-Yun Yang, L. Rossetti, J. Donohoe, E. Alt, Chee-Jen Chang, R. Rosenfeld, K. Neely, R. Hintz   +8 more
semanticscholar   +1 more source

Effects of insulin, insulin-like growth factor-II, and nerve growth factor on neurite formation and survival in cultured sympathetic and sensory neurons

Journal of Neuroscience, 1986
Insulin and the insulin-like growth factors (IGFs) may directly affect the development of the nervous system. NGF, IGF-II, and insulin's effects on neurite formation and neuronal survival were studied in peripheral ganglion cell cultures from chick ...
E. Recio-Pinto, M. Rechler, D. Ishii
semanticscholar   +1 more source

Insulin-like Growth Factor-II, Phosphatidylinositol 3-Kinase, Nuclear Factor-κB and Inducible Nitric-oxide Synthase Define a Common Myogenic Signaling Pathway*

Journal of Biological Chemistry, 1999
Insulin-like growth factors (IGFs) are potent inducers of skeletal muscle differentiation and phosphatidylinositol (PI) 3-kinase activity is essential for this process. Here we show that IGF-II induces nuclear factor-κB (NF-κB) and nitric-oxide synthase (
P. Kaliman, J. Canicio, X. Testar, M. Palacín, A. Zorzano   +4 more
semanticscholar   +1 more source

Imprinting and Promoter Usage of Insulin-Like Growth Factor II in Twin Discordant Placenta

Obstetrics and Gynecology International, 2010
Case reports from infant twins suggest that abnormal genomic imprinting may be one of the important causes of twin discordance, but it is unknown whether abnormal genomic imprinting occurs in the placenta.
Yan-Min Luo, Qun Fang, Hui-Juan Shi, Lin-Huan Huang, Run-Cai Liang, Guang-Lun Zhuang   +5 more
doaj   +1 more source

Non-Islet Cell Tumor Hypoglycemia at the Second Recurrence of Malignant Solitary Fibrous Tumor in the Retroperitoneum and Pelvis: A Case Report

Case Reports in Oncology, 2012
An 83-year-old man underwent complete resection of a large malignant solitary fibrous tumor in the retroperitoneum in 2006 and of a local recurrent tumor in 2010. In 2011, he was admitted to our hospital because of hypoglycemia.
Tatsuo Hata, Yoshihiko Tsuruta, Shigeru Takamori, Yuri Shishikura   +3 more
doaj   +1 more source

Insulin-like growth factor II gene Apa I polymorphism is not associated with endometriosis susceptibility

Genetics and Molecular Biology, 2004
Insulin-like growth factor II (IGF2) has been shown to play a role in abnormal cell growth and carcinogenesis. We investigated if the IGF2 gene Apa I polymorphism at exon 9 was associated with the susceptibility to endometriosis, analyzing 120 women with
Yao-Yuan Hsieh, Chi-Chen Chang, Fuu-Jen Tsai, Ching-Tien Peng, Lian-Shun Yeh, Cheng-Chieh Lin   +5 more
doaj   +1 more source

Characterization of insulin-like-growth factor II (IGF II) mRNA positive hepatic altered foci and IGF II expression in hepatocellular carcinoma during diethylnitrosamine-induced hepatocarcinogenesis in rats

Journal of Carcinogenesis, 2005
Background Insulin-like-growth factor II (IGF II) has been implicated in the pathogenesis of neoplasm of different tissues, including liver of rats and men. This growth factor is believed to exert its effect during cellular proliferation.
B. Mukherjee, Shampa Ghosh, Tanushree Das, M. Doloi   +3 more
semanticscholar   +1 more source

The RNA-binding Protein IMP-3 Is a Translational Activator of Insulin-like Growth Factor II Leader-3 mRNA during Proliferation of Human K562 Leukemia Cells*

Journal of Biological Chemistry, 2005
IMP-3, a member of the insulin-like growth factor-II (IGF-II) mRNA-binding protein (IMP) family, is expressed mainly during embryonic development and in some tumors. Thus, IMP-3 is considered to be an oncofetal protein. The functional significance of IMP-
B. Liao, Yan Hu, D. Herrick, G. Brewer
semanticscholar   +1 more source

A 24-Hour Study of the Hypothalamo-Pituitary Axes in Huntington's Disease. [PDF]

PLoS ONE, 2015
Huntington's disease is an inherited neurodegenerative disorder characterised by motor, cognitive and psychiatric disturbances. Patients exhibit other symptoms including sleep and mood disturbances, muscle atrophy and weight loss which may be linked to ...
Eirini Kalliolia, Edina Silajdžić, Rajasree Nambron, Seán J Costelloe, Nicholas G Martin, Nathan R Hill, Chris Frost, Hilary C Watt, Peter Hindmarsh, Maria Björkqvist, Thomas T Warner   +10 more
doaj   +1 more source

A Rare Cause of Severe Hypoglycemia in Intracranial Hemangiopericytoma Associated With Non-Islet Cell Tumor Hypoglycemia

Annals of Internal Medicine: Clinical Cases, 2022
A 60-year-old man with a history of metastatic intracranial hemangiopericytoma and type 2 diabetes mellitus presented with acute episodes of confusion and dizziness.
Natnicha Leelaviwat, Nouran Eshak, Poemlarp Mekraksakit, Ana Cordon, Anupa Patel   +4 more
doaj   +1 more source