Results 21 to 30 of about 18,925,600 (331)

A novel insulin-like growth factor II-based masking domain for conditional activation of therapeutic antibodies [PDF]

mAbs
Systemic target engagement constrains the therapeutic index of many antibody drugs, particularly in inflammatory disease and immuno-oncology. Protease-cleavable masking can localize activity to disease sites, but existing approaches often tradeoff ...
Lihua Shi, Minseon Cho, Motohiko Nishida, Mark L. Chiu, Di Zhang   +4 more
doaj   +2 more sources

Relationship between Metal Pollution and Gene Expression of Insulin-like Growth Factor II [PDF]

Journal of Health and Pollution, 2018
Background. Metals pollution plays an important role in the regulation of gene expression through interference with signal transduction pathways which are important for cell bioactivity. Objectives.
Aziza A. Saad, Amany El-Sikaily, Maher A. Kamel, Hany Kassem, Mohamed S. Abdel-Latif   +4 more
doaj   +2 more sources

Insulin-like growth factor (IGF)-II- mediated fibrosis in pathogenic lung conditions.

PLoS ONE, 2019
Type 2 insulin-like growth factor (IGF-II) levels are increased in fibrosing lung diseases such as idiopathic pulmonary fibrosis (IPF) and scleroderma/systemic sclerosis-associated pulmonary fibrosis (SSc). Our goal was to investigate the contribution of
Sara M Garrett, Eileen Hsu, Justin M Thomas, Joseph M Pilewski, Carol Feghali-Bostwick   +4 more
doaj   +2 more sources

Insulin-like growth factors: Ligands, binding proteins, and receptors

Molecular Metabolism, 2021
Background: The insulin-like growth factor family of ligands (IGF-I, IGF-II, and insulin), receptors (IGF-IR, M6P/IGF-IIR, and insulin receptor [IR]), and IGF-binding proteins (IGFBP-1-6) play critical roles in normal human physiology and disease states.
Derek LeRoith, Jeff M.P. Holly, Briony E. Forbes   +2 more
doaj   +3 more sources

Insulin-like growth factor-II and bioactive proteins containing a part of the E-domain of pro-insulin-like growth factor-II. [PDF]

Biofactors, 2020
AbstractInsulin‐like growth factor (IGF)‐II is considered to function as an important fetal growth factor, which is structurally and functionally related to IGF‐I and proinsulin. At least in vitro, IGF‐II actions are mediated through the IGF‐I receptor and to a lesser extent the insulin receptor.
van Doorn J.
europepmc   +6 more sources

Associations of insulin and insulin-like growth factors with physical performance in old age in the boyd orr and caerphilly studies. [PDF]

, 2012
OBJECTIVE: Insulin and the insulin-like growth factor (IGF) system regulate growth and are involved in determining muscle mass, strength and body composition.
David Gunnell, Gunnell, David, Gallacher, John, Martin, Richard M., Birnie, K, Gunnell, D, Kate Birnie, Gunnell David, Antony Bayer, Bayer Antony, John Gallacher, Ebrahim, S, Holly, Jeff MP, Bayer, A, Yoav Ben-Shlomo, Birnie Kate, Shah Ebrahim, Ben-Shlomo, Y, Ebrahim, Shah, Jeff M P Holly, Gunnell, DJ, Gallacher, J, Martin, Richard M, Holly, JM, Bayer, Antony, Jeff M. P. Holly, Martin Richard M., Martin, RM, Richard M Martin, Richard M. Martin, Holly Jeff M. P., Gallacher John, Holly, JMP, Holly, Jeff M. P., Bayer, Antony James, Birnie, Kate, Ben-Shlomo, Yoav, Ben-Shlomo Yoav, Ebrahim Shah, Gallacher, John Edward   +39 more
core   +5 more sources

A case of nonislet cell tumor hypoglycemia associated with malignant mesothelioma requiring a multifaceted approach for optimal glycemic control

Clinical Case Reports, 2021
Nonislet tumor hypoglycemia (NICTH) is a rare paraneoplastic syndrome characterized by refractory hypoglycemia, which often requires multifaceted therapy.
Mariko Ono, Yuki Maeda, Nobuyuki Koyama, Terumasa Nagase, Yoshiya Katsura, Hiroyuki Nakamura, Kazutetsu Aoshiba   +6 more
doaj   +1 more source

The receptor for insulin‐like growth factor II mediates an insulin‐like response. [PDF]

The EMBO Journal, 1987
Insulin-like growth factor II (IGF-II) shares sequence homology and predicted three-dimensional structure with insulin and IGF-I. IGF-II can bind, therefore, to a limited extent with the receptors for these two other hormones, as well as to a distinct receptor for IGF-II.
J, Hari, S B, Pierce, D O, Morgan, V, Sara, M C, Smith, R A, Roth   +5 more
openaire   +2 more sources

Malignant fibroma presenting as a hypoglycemia and coma in a 45‐year‐old male patient: A case report

Clinical Case Reports, 2022
Solitary fibrous tumors (SFTs) are a rare group of spindle cell neoplasm of submesothelial origin with malignant potential and can present as hypoglycemia secondary to excess secretion of insulin‐like growth factor II (IGF‐II) from the tumor.
Muhammad Hanif, Vikash Jaiswal, Sidra Naz, Nirmit Patel, Nishan Babu Pokhrel, Mounika Reddy Vadiyala   +5 more
doaj   +1 more source

Expression of insulin-like growth factor II and receptors for insulin-like growth factor II, insulin-like growth factor I and insulin in isolated and cultured rat hepatocytes [PDF]

Hepatology, 1991
Insulin-like growth factor II is believed to play an important role in fetal growth and development. The insulin-like growth factor II gene expression is tissue specific and developmentally regulated. We have previously shown an enhanced level of insulin-like growth factor II messenger RNA and protein in human hepatocellular ...
E, Lamas, F, Zindy, D, Seurin, C, Guguen-Guillouzo, C, Brechot   +4 more
openaire   +3 more sources