Surgical resection of a retroperitoneal liposarcoma producing insulin-like growth factor II: a case report [PDF]
Surgical Case Reports, 2023 Background Tumor-produced high molecular weight insulin-like growth factor-II (big insulin-like growth factor-II) is considered to cause non-islet cell tumor hypoglycemia. This paper presents a case of surgically resected retroperitoneal liposarcoma that
Noriyuki Nishiwaki +11 more
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Insulin-Like Growth Factor-II and Ischemic Stroke—A Prospective Observational Study [PDF]
Life, 2021 Insulin-like growth factor-II (IGF-II) regulates prenatal brain development, but the role in adult brain function and injury is unclear. Here, we determined whether serum levels of IGF-II (s-IGF-II) are associated with mortality and functional outcome ...
Daniel Åberg +7 more
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Insulin-like growth factor II prevents oxidative and neuronal damage in cellular and mice models of Parkinson's disease [PDF]
Redox Biology, 2021 Oxidative distress and mitochondrial dysfunction, are key factors involved in the pathophysiology of Parkinson's disease (PD). The pleiotropic hormone insulin-like growth factor II (IGF-II) has shown neuroprotective and antioxidant effects in some ...
Elisa Martín-Montañez +13 more
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Insulin-like Growth Factor II Prevents MPP+ and Glucocorticoid Mitochondrial-Oxidative and Neuronal Damage in Dopaminergic Neurons [PDF]
Antioxidants, 2021 Stress seems to contribute to Parkinson’s disease (PD) neuropathology, probably by dysregulation of the hypothalamic–pituitary–adrenal axis.
Silvia Claros +9 more
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Association of insulin-like growth factor II mrna-binding protein 3 (IMP3) expression with prognostic and morphological factors in endometrial cancer [PDF]
Revista Brasileira de Ginecologia e ObstetríciaObjective Endometrial cancer (EC) is a heterogeneous disease with recurrence rates ranging from 15 to 20%. The discrimination of cases with a worse prognosis aims, in part, to reduce the length of surgical staging in cases with a better prognosis.
Silas Otero Reis Salum +5 more
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Insulin-like growth factor-II: new roles for an old actor [PDF]
Frontiers in Endocrinology, 2012 IGF-II, traditionally considered as a growth factor implicated in growth of fetal tissues and cancer cells, is now emerging as a potential metabolic regulator.
Stefano eCianfarani
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Relationship between Metal Pollution and Gene Expression of Insulin-like Growth Factor II [PDF]
Journal of Health and Pollution, 2018 Background. Metals pollution plays an important role in the regulation of gene expression through interference with signal transduction pathways which are important for cell bioactivity. Objectives.
Aziza A. Saad +4 more
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A novel insulin-like growth factor II-based masking domain for conditional activation of therapeutic antibodies [PDF]
mAbsSystemic target engagement constrains the therapeutic index of many antibody drugs, particularly in inflammatory disease and immuno-oncology. Protease-cleavable masking can localize activity to disease sites, but existing approaches often tradeoff ...
Lihua Shi +4 more
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Insulin-like Growth Factor II: An Essential Adult Stem Cell Niche Constituent in Brain and Intestine [PDF]
Stem Cell Reports, 2019 Summary: Tissue-specific stem cells have unique properties and growth requirements, but a small set of juxtacrine and paracrine signals have been identified that are required across multiple niches.
Amber N. Ziegler +12 more
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Clinical Case Reports, 2021 Nonislet tumor hypoglycemia (NICTH) is a rare paraneoplastic syndrome characterized by refractory hypoglycemia, which often requires multifaceted therapy.
Mariko Ono +6 more
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