Surgical resection of a retroperitoneal liposarcoma producing insulin-like growth factor II: a case report [PDF]
Surgical Case Reports, 2023 Background Tumor-produced high molecular weight insulin-like growth factor-II (big insulin-like growth factor-II) is considered to cause non-islet cell tumor hypoglycemia. This paper presents a case of surgically resected retroperitoneal liposarcoma that
Noriyuki Nishiwaki +11 more
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Insulin-Like Growth Factor-II and Ischemic Stroke—A Prospective Observational Study [PDF]
Life, 2021 Insulin-like growth factor-II (IGF-II) regulates prenatal brain development, but the role in adult brain function and injury is unclear. Here, we determined whether serum levels of IGF-II (s-IGF-II) are associated with mortality and functional outcome ...
Daniel Åberg +7 more
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Insulin-like growth factor II prevents oxidative and neuronal damage in cellular and mice models of Parkinson's disease [PDF]
Redox Biology, 2021 Oxidative distress and mitochondrial dysfunction, are key factors involved in the pathophysiology of Parkinson's disease (PD). The pleiotropic hormone insulin-like growth factor II (IGF-II) has shown neuroprotective and antioxidant effects in some ...
Elisa Martín-Montañez +13 more
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Temporal expression pattern of the insulin-like growth factor II and fibroblast growth factor transcripts in avian embryogenesis [PDF]
Brazilian Archives of Biology and Technology, 2008 In this study, the abundance of IGF-II and bFGF transcripts was estimated in the chicken embryos using the competitive RT-PCR analysis. Significant enhancements in the abundance of IGF-II mRNA were observed at stages HH1 and 5, and a new accumulation in ...
Jane Eyre Gabriel +2 more
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Insulin-like growth factor-II and bioactive proteins containing a part of the E-domain of pro-insulin-like growth factor-II. [PDF]
Biofactors, 2020 AbstractInsulin‐like growth factor (IGF)‐II is considered to function as an important fetal growth factor, which is structurally and functionally related to IGF‐I and proinsulin. At least in vitro, IGF‐II actions are mediated through the IGF‐I receptor and to a lesser extent the insulin receptor.
van Doorn J.
europepmc +4 more sources
Probing Receptor Specificity by Sampling the Conformational Space of the Insulin-like Growth Factor II C-domain. [PDF]
J Biol Chem, 2016 Insulin and insulin-like growth factors I and II are closely related protein hormones. Their distinct evolution has resulted in different yet overlapping biological functions with insulin becoming a key regulator of metabolism, whereas insulin-like ...
Hexnerová R +13 more
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Acta Obstetricia et Gynecologica Scandinavica, 1997 Background. The purpose of this study was to investigate unprecedentedly immunohistochemical localization of insulin‐like growth factor I, insulin‐like growth factor I receptor and insulin‐like growth factor II in endometriotic tissue, and to compare ...
Shiuh Y. Chang, Yat‐Sen Ho
doaj +3 more sources
Insulin-like growth factor-II: new roles for an old actor [PDF]
Frontiers in Endocrinology, 2012 IGF-II, traditionally considered as a growth factor implicated in growth of fetal tissues and cancer cells, is now emerging as a potential metabolic regulator.
Stefano eCianfarani
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Association of insulin-like growth factor II mrna-binding protein 3 (IMP3) expression with prognostic and morphological factors in endometrial cancer [PDF]
Revista Brasileira de Ginecologia e ObstetríciaObjective Endometrial cancer (EC) is a heterogeneous disease with recurrence rates ranging from 15 to 20%. The discrimination of cases with a worse prognosis aims, in part, to reduce the length of surgical staging in cases with a better prognosis.
Silas Otero Reis Salum +5 more
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Insulin-like Growth Factor II Prevents MPP+ and Glucocorticoid Mitochondrial-Oxidative and Neuronal Damage in Dopaminergic Neurons [PDF]
Antioxidants, 2021 Stress seems to contribute to Parkinson’s disease (PD) neuropathology, probably by dysregulation of the hypothalamic–pituitary–adrenal axis.
Silvia Claros +9 more
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