Results 1 to 10 of about 349,499 (162)

Insulin like growth factor – insulin like growth factor binding protein family in osteoporosis: mechanistic and clinical insights [PDF]

Annals of Medicine
Introduction The imbalance between osteoblasts and osteoclasts is central to osteoporosis.Insulin like growth factor (IGF) has protective effects on bone. As an IGF-binding protein, the role of IGFBP in bone has also begun to come into the public’s view.
Xiuwen Wang, Jie Zhang, Zhidan Luo
doaj   +2 more sources

Role of insulin-like growth factor, insulin-like growth factor receptors, and insulin-like growth factor-binding proteins in ovarian cancer

Indian Journal of Medical and Paediatric Oncology, 2017
Insulin and IGFs play an important role in cancer initiation and progression, including ovarian cancer (OC). Epithelial ovarian cancer (EOC) is the most frequent type of OC in women and it is the most lethal gynecological malignancy worldwide. Generally,
Periyasamy Amutha, Thangarajan Rajkumar
doaj   +3 more sources

Insulin-like growth factors: Ligands, binding proteins, and receptors

Molecular Metabolism, 2021
Background: The insulin-like growth factor family of ligands (IGF-I, IGF-II, and insulin), receptors (IGF-IR, M6P/IGF-IIR, and insulin receptor [IR]), and IGF-binding proteins (IGFBP-1-6) play critical roles in normal human physiology and disease states.
Derek LeRoith, Jeff M.P. Holly, Briony E. Forbes   +2 more
doaj   +3 more sources

Insulin-like growth factor-1/insulin-like growth factor-1 receptor signalling in macrophages facilitates recovery from acute lung injury [PDF]

Annals of Medicine
Background No effective treatment strategy for acute respiratory distress syndrome (ARDS) has been established. Conflicting reports on the effects of insulin-like growth factor (IGF)-1 stimulation and the inhibition of IGF-1 receptor (IGF-1R) signalling ...
Miyuki Niisato, Masahiro Yamashita, Yasushi Kawasaki, Hiroshi Furukawa, Takashi Sato, Ichiro Kawada   +5 more
doaj   +2 more sources

Insulin-like growth factor family and its impact on pulmonary arterial hypertension: a review [PDF]

Frontiers in Physiology
Pulmonary arterial hypertension (PAH) is a progressive and life-threatening cardiopulmonary disorder with rising global prevalence and limited curative options.
Nuo Li, Nuo Li, Degang Mo, Hongyan Dai
doaj   +2 more sources

Insulin-like growth factor type 2 is a better survival marker than insulin-like growth factor type 1 in patients after acute decompensated heart failure

Archives of Medical Science, 2023
Introduction A decreased insulin-like growth factor 1 (IGF-1) level has been found in heart failure (HF). There are no reports assessing IGF-2 in HF, although in vitro research has shown that IGF-2 stimulates cardiomyocyte proliferation more than IGF-1 ...
Agata Bronisz, Bartosz J. Myśliwiec, Magdalena Hagner–Derengowska, John Xerri de Caro, Marek Bronisz   +4 more
doaj   +1 more source

Correlation of Insulin Like Growth Factor-1 and Insulin-Like Growth Factor Binding Protein with LH, FSH and Testosterone in Iraqi Children with Growth Hormone Deficiency

Iraqi Journal of Chemical and Petroleum Engineering, 2023
Insulin like growth factor-1 has metabolic and growth-related roles all over the body and is strongly associated and regulated by growth hormone. It is produced by almost any type of tissue, especially the liver.
Athraa F. Hasan, Bushra F. Hassan, ABDILKAREEM Y. AL-SAMERAIE   +2 more
doaj   +1 more source

Chronic inflammation and the growth hormone/insulin-like growth factor-1 axis

Central European Journal of Immunology, 2021
Interactions between growth hormone (GH), insulin-like growth factor-1 (IGF-1), and the immune system are complex, bidirectional, but not fully explained.
Ewelina Witkowska-Sędek, Beata Pyrżak
doaj   +1 more source

Insulin Like Growth Factor Binding Protein 7 as a Novel Diagnostic Marker in Sera of Iraqi Patients with Acromegaly

مجلة بغداد للعلوم, 2023
The purpose of this study was to measure serum levels of insulin-like growth factor-binding protein (IGFBP7), Insulin-like Growth Factor 1 (IGF-1), Growth Hormone (GH), Interleukin 6 (IL-6) and insulin in acromegaly patients and healthy controls.
Layla Othman Farhan, Baydaa Ahmed Abed, Kashtl Ghasaq J., Isam Noori Salman   +3 more
doaj   +1 more source

IGF-Binding Proteins: Why Do They Exist and Why Are There So Many?

Frontiers in Endocrinology, 2018
Insulin-like growth factors (IGFs) are key growth-promoting peptides that act as both endocrine hormones and autocrine/paracrine growth factors. In the bloodstream and in local tissues, most IGF molecules are bound by one of the members of the IGF ...
John B. Allard, Cunming Duan
doaj   +1 more source