Results 1 to 10 of about 537,907 (152)

Monoclonal antibodies to receptors for insulin and somatomedin-C. [PDF]

Journal of Biological Chemistry, 1983
Three monoclonal antibodies, designated alpha IR-1, alpha IR-2, and alpha IR-3, were prepared by fusing FO myeloma cells with spleen cells from a mouse immunized with a partially purified preparation of insulin receptors from human placenta. These antibodies were characterized by their ability to immunoprecipitate solubilized receptors labeled with ...
F C, Kull, S, Jacobs, Y F, Su, M E, Svoboda, J J, Van Wyk, P, Cuatrecasas   +5 more
openaire   +3 more sources

Association of Acromegaly and Multiple Myeloma: A Case Report

Endocrinology Research and Practice, 2013
Malignancy is an important cause of mortality in acromegaly. Hematological malignancies are very rare in acromegaly. Here, we report an 80-year-old patient with acromegaly and multiple myeloma. Patient died within a month of diagnosis.
Murat Atmaca, Saliha Yıldız, Işılay Kalan, Mehmet Fatih Özbay, İsmet Seven, Mustafa Öztürk   +5 more
doaj   +1 more source

Ontogenesis of somatomedin and insulin receptors in the human fetus. [PDF]

Journal of Clinical Investigation, 1983
This study examines the ontogenesis of somatomedin and insulin receptors in man. Particulate plasma membranes were prepared by ultracentrifugation from various tissues removed from fetuses after abortion and classified as less than 17, 17-25, and greater than 25 cm in length.
V R, Sara, K, Hall, M, Misaki, L, Fryklund, N, Christensen, L, Wetterberg   +5 more
openaire   +2 more sources

Monensin blocks the maturation of receptors for insulin and somatomedin C: Identification of receptor precursors [PDF]

Proceedings of the National Academy of Sciences, 1983
Cultured human lymphoid (IM-9) cells were labeled with [ 35 S]methionine in the presence and absence of monensin, a carboxylic ionophore that inhibits post-translational protein maturation. Labeled receptors for insulin and somatomedin C were immunoprecipitated with antibodies specific for ...
S, Jacobs, F C, Kull, P, Cuatrecasas
openaire   +2 more sources

Relationship of Insulin-like Growth Factor Receptor Single Nucleotide 
Polymorphism (SNP) with Platinum-based Chemotherapy Outcomes in Advanced Non-small Cell Lung Cancer

Chinese Journal of Lung Cancer, 2012
Background and objective It has been proven that the insulin-like growth factor 1 receptor (IGF-1R) gene is an important regulator of many aspects of growth, differentiation, and development.
Yusheng CHEN, Hui SHAO, Hongru LI, Lili HAN, Xiang'e ZHANG   +4 more
doaj   +1 more source

Stimulation of glycosaminoglycan synthesis by somatomedin and insulin in rat chondrocytes via somatomedin receptors.

Endocrinologia Japonica, 1984
Using cultured normal rat chondrocytes we have investigated 1) the effects of somatomedin and insulin on glycosaminoglycan (GAG) synthesis and 2) somatomedin and insulin binding sites. We confirmed that somatomedin and insulin stimulate GAG synthesis in normal rat chondrocytes.
ASAKAWA, KUMIKO, TAKANO, KAZUE, HIZUKA, NAOMI, KOGAWA, MEGUMI, SHIZUME, KAZUO   +4 more
openaire   +3 more sources

Competitive Binding of Somatomedin to the Insulin Receptors of Adipocytes, Chondrocytes, and Liver Membranes [PDF]

Proceedings of the National Academy of Sciences, 1972
The action of growth hormone on skeletal tissue is mediated through somatomedin, a low molecular weight peptide found in serum. This peptide, formerly known as “sulfation factor” or “thymidine factor,” produces marked insulin-like effects in various target tissues.
R L, Hintz, D R, Clemmons, L E, Underwood, J J, Van Wyk   +3 more
openaire   +2 more sources

The relationship between the concentration of insulin-like growth factor, leptin and lipid metabolism indices in the blood of dairy cows during different physiological periods

Науковий вісник Львівського національного університету ветеринарної медицини та біотехнологій імені С.З. Ґжицького: Серія Ветеринарні науки
Despite the evidence of the fundamental influence of the endocrine system on metabolism in ruminants, there is little literature on hormonal status. There is insufficient data on tissue hormones, particularly insulin-like growth factor and leptin.
M. R. Simonov, V. V. Vlizlo, T. О. Pundiak, B. V. Gutyj, L. G. Slivinska, I. I. Kovalchuk   +5 more
doaj   +1 more source

Presence of somatomedin receptors on primary human breast and colon carcinomas

Cancer Letters, 1987
Competitive binding techniques were used to study the interaction of insulin-like growth factor I (IGF-I) with a plasma membrane-enriched subcellular fraction purified from primary breast and colon carcinoma specimens obtained at surgery. The presence of specific binding sites for IGF-I was detected in all tumour specimens studied.
Pollak, Michael N., Perdue, James F., Margolese, Richard G., Baer, Kathy, Richard, Martine   +4 more
openaire   +3 more sources

Phorbol esters stimulate the phosphorylation of receptors for insulin and somatomedin C. [PDF]

Proceedings of the National Academy of Sciences, 1983
The effect of phorbol esters on the extent of phosphorylation of receptors for insulin and somatomedin C (insulin-like growth factor I) was studied in intact IM-9 cells that were labeled by incubation with H332PO4. The tumor-promoting phorbol esters phorbol tetradecanoate acetate (TPA) and phorbol dibutyrate, but not the inactive 4 alpha-phorbol ...
S, Jacobs, N E, Sahyoun, A R, Saltiel, P, Cuatrecasas   +3 more
openaire   +2 more sources