Results 21 to 30 of about 537,907 (152)

Expression of the insulin-like growth factor-II/mannose-6-phosphate receptor in multiple human tissues during fetal life and early infancy [PDF]

, 1992
The insulin like growth factor-II/mannose-6-phosphate (IGF-II/M6P) receptor has been detected in many cells and tissues. In the rat, there is a dramatic developmental regulation of IGF-II/M6P receptor expression, the receptor being high in fetal and ...
Eisenmenger, Wolfgang, Kiess, W., Kolb, H. J., Funk, B., Kessler, U., Hansmann, A.   +5 more
core   +1 more source

Intact pulse cotyledon cell diet improves systemic growth via the somatotropic axis in malnourished mice

iMetaOmics, Volume 3, Issue 1, March 2026.
The MAL‐IC diet promotes growth in malnourished mice by regulating the gut microbiota—increasing the abundance of carbohydrate‐utilizing bacteria and SCFAs production. SCFAs circulate to the liver via the gut–liver axis, where they bind FFAR2 and activate the somatotropic axis, thereby stimulating GHR‐mediated GH signaling and increasing IGF‐1 and ...
Yumeng Yan, Zhuqing Xie, Zhipeng Gu, Zhongxin Li, Qiang Huang, Bin Zhang   +5 more
wiley   +1 more source

Dietary components that regulate serum somatomedin-C concentrations in humans. [PDF]

, 1983
Dietary components responsible for the regulation of somatomedin-C in humans were assessed in five adult volunteers of normal weight who were fasted for 5 d on three occasions, then refed three diets of differing composition.
Isley, W L, Underwood, L E, Clemmons, D R, D R Clemmons, L E Underwood, W L Isley   +5 more
core   +1 more source

Somatomedin receptor of human placenta: solubilization, photolabeling, partial purification, and comparison with insulin receptor. [PDF]

Proceedings of the National Academy of Sciences, 1981
Using a recently isolated human basic somatomedin (basic SM) similar to insulin-like growth factor I (IGF-I), we studied both the photoaffinity-labeled and unlabeled basic-SM receptor solubilized from human placental cell membranes. Unlike the result with the insulin receptor, high yields of soluble basic-SM-binding activity are obtained with Triton X ...
B, Bhaumick, R M, Bala, M D, Hollenberg
openaire   +2 more sources

SUSD2 Promotes Metastasis and Primary Tumor Growth in Pancreatic Cancer Cells via Integrin–FAK Signaling Activation

Cancer Science, Volume 117, Issue 3, Page 711-726, March 2026.
This study investigates the role of Sushi domain‐containing 2 (SUSD2) in pancreatic ductal adenocarcinoma (PDAC) and demonstrates that SUSD2 enhances both metastasis and primary tumor growth by promoting integrin β1–FAK signaling. SUSD2 interacts with integrin β1, enhancing adhesion to extracellular matrix (ECM) components such as collagen 1 and ...
Junjiro Yoshida, Tomokazu Ohishi, Isao Momose, Shun‐ichi Ohba, Kyohei Kurosawa, Akiko Harakawa, Hiroyuki Inoue, Minori Senoo, Daisuke Tatsuda, Hikaru Abe, Atsushi Masamune, Manabu Kawada   +11 more
wiley   +1 more source

Structural basis for uPAR binding to an antibody developed for targeted cancer therapy. Mechanistic insights into flexibility, ligand recognition, and molecular imaging

Protein Science, Volume 35, Issue 2, February 2026.
Abstract The urokinase‐type plasminogen activator receptor (uPAR) is currently gaining momentum as a promising molecular target for treatment of various solid cancers. For patient stratification, we developed a high‐affinity uPAR‐targeting peptide (AE105) detecting primary cancer lesions as well as occult metastasis by positron emission tomography (PET)
Rex F. Anane, Anni Kumari, Hari Venugopal, Sylvain Trépout, James C. Whisstock, Lars H. Engelholm, Ruby H. P. Law, Michael Ploug   +7 more
wiley   +1 more source

Endogenous mediators of growth [PDF]

, 1990
In the present review it is not possible to discuss the effects of the numerous endogenous mediators of growth. What we have attempted to do is to indicate the areas of controversy and the need for further research. In our view, four main questions arise.
Farquharson, C, Loveridge, N, Farquharson, C; id_orcid, Scheven, B A   +3 more
core  

Potentiation of glycine-gated NR1/NR3A NMDA receptors relieves Ca2+-dependent outward rectification [PDF]

, 2010
Glycine has diverse functions within the mammalian central nervous system. It inhibits postsynaptic neurons via strychnine-sensitive glycine receptors (GlyRs) and enhances neuronal excitation through co-activation of N-methyl-D-aspartate (NMDA) receptors.
Betz, H., Christian Madry, Geiger, Jörg R. P., Bodo Laube, Betz, Heinrich, Jörg Geiger, Laube, B., Madry, Christian, Madry, C., Geiger, J., Laube, Bodo, Heinrich Betz   +11 more
core   +1 more source

Massive reduction of RyR1 in muscle spindles of mice carrying recessive Ryr1 mutations alters proprioception and causes scoliosis

The Journal of Physiology, Volume 603, Issue 22, Page 6949-6977, November 15, 2025.
Abstract figure legend Intrafusal muscles contained within muscle spindles are endowed with ryanodie receptor 1 (RyR1) calcium channels and participate in proprioceptor function. Mutations in RyR1 linked to severe RYR1‐congenital myopathies affect calcium release from both extrafusal as well as intrafusal muscles.
Alexis Ruiz, Sofia Benucci, Hervé Meier, Georg Schultz, Katarzyna Buczak, Christoph Handschin, Rodrigo C. G. Pena, Susan Treves, Francesco Zorzato   +8 more
wiley   +1 more source

Delayed Bone Maturation and Extended Growth Phase as Distinctive Features of 17α‐Hydroxylase/17,20‐Lyase Deficiency: A Retro‐Prospective Study of a Large Patient Cohort

Clinical Endocrinology, Volume 103, Issue 3, Page 303-310, September 2025.
ABSTRACT Introduction Worldwide, combined 17‐hydroxylase/17,20‐lyase deficiency (CYP17D) is a rare form of congenital adrenal hyperplasia, but it is the second most prevalent type in Brazil. An absence of sexual differentiation and hypergonadotropic hypogonadism arise from a reduction in the usual pattern of sex steroid formation in the adrenals and ...
Rafaela Fontenele, Flávia A. Costa‐Barbosa, Marivânia Costa‐Santos, Rafael L. Batista, Lívia M. Mermejo, Berenice B. Mendonça, Margaret de Castro, Gil Guerra‐Júnior, Claudio E. Kater, Brazilian Congenital Adrenal Hyperplasia Multicenter Study Group (BCAHMSG)   +9 more
wiley   +1 more source