Results 11 to 20 of about 2,018 (137)
Presence of somatomedin receptors on primary human breast and colon carcinomas
Cancer Letters, 1987 Competitive binding techniques were used to study the interaction of insulin-like growth factor I (IGF-I) with a plasma membrane-enriched subcellular fraction purified from primary breast and colon carcinoma specimens obtained at surgery. The presence of specific binding sites for IGF-I was detected in all tumour specimens studied.
Pollak, Michael N. +4 more
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Somatomedin receptor of human placenta: solubilization, photolabeling, partial purification, and comparison with insulin receptor. [PDF]
Proceedings of the National Academy of Sciences, 1981 Using a recently isolated human basic somatomedin (basic SM) similar to insulin-like growth factor I (IGF-I), we studied both the photoaffinity-labeled and unlabeled basic-SM receptor solubilized from human placental cell membranes. Unlike the result with the insulin receptor, high yields of soluble basic-SM-binding activity are obtained with Triton X ...
B, Bhaumick, R M, Bala, M D, Hollenberg
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iMetaOmics, Volume 3, Issue 1, March 2026.The MAL‐IC diet promotes growth in malnourished mice by regulating the gut microbiota—increasing the abundance of carbohydrate‐utilizing bacteria and SCFAs production. SCFAs circulate to the liver via the gut–liver axis, where they bind FFAR2 and activate the somatotropic axis, thereby stimulating GHR‐mediated GH signaling and increasing IGF‐1 and ...
Yumeng Yan +5 more
wiley +1 more source
Phorbol esters stimulate the phosphorylation of receptors for insulin and somatomedin C. [PDF]
Proceedings of the National Academy of Sciences, 1983 The effect of phorbol esters on the extent of phosphorylation of receptors for insulin and somatomedin C (insulin-like growth factor I) was studied in intact IM-9 cells that were labeled by incubation with H332PO4. The tumor-promoting phorbol esters phorbol tetradecanoate acetate (TPA) and phorbol dibutyrate, but not the inactive 4 alpha-phorbol ...
S, Jacobs +3 more
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Cancer Science, Volume 117, Issue 3, Page 711-726, March 2026.This study investigates the role of Sushi domain‐containing 2 (SUSD2) in pancreatic ductal adenocarcinoma (PDAC) and demonstrates that SUSD2 enhances both metastasis and primary tumor growth by promoting integrin β1–FAK signaling. SUSD2 interacts with integrin β1, enhancing adhesion to extracellular matrix (ECM) components such as collagen 1 and ...
Junjiro Yoshida +11 more
wiley +1 more source
Protein Science, Volume 35, Issue 2, February 2026.Abstract The urokinase‐type plasminogen activator receptor (uPAR) is currently gaining momentum as a promising molecular target for treatment of various solid cancers. For patient stratification, we developed a high‐affinity uPAR‐targeting peptide (AE105) detecting primary cancer lesions as well as occult metastasis by positron emission tomography (PET)
Rex F. Anane +7 more
wiley +1 more source
The Journal of Physiology, Volume 603, Issue 22, Page 6949-6977, November 15, 2025.Abstract figure legend Intrafusal muscles contained within muscle spindles are endowed with ryanodie receptor 1 (RyR1) calcium channels and participate in proprioceptor function. Mutations in RyR1 linked to severe RYR1‐congenital myopathies affect calcium release from both extrafusal as well as intrafusal muscles.
Alexis Ruiz +8 more
wiley +1 more source
Clinical Endocrinology, Volume 103, Issue 3, Page 303-310, September 2025.ABSTRACT Introduction Worldwide, combined 17‐hydroxylase/17,20‐lyase deficiency (CYP17D) is a rare form of congenital adrenal hyperplasia, but it is the second most prevalent type in Brazil. An absence of sexual differentiation and hypergonadotropic hypogonadism arise from a reduction in the usual pattern of sex steroid formation in the adrenals and ...
Rafaela Fontenele +9 more
wiley +1 more source
Acta Crystallographica Section D, Volume 81, Issue 8, Page 451-464, August 2025.Very high‐resolution fatty acid‐binding protein structures identified a substantial number of ligands that differ strongly from their expected structure. If different ligand chemistry is a potentially overlooked problem in other, lower resolution, crystal structures of protein–ligand complexes, it has repercussions for any study using such structures ...
Andreas Ehler +4 more
wiley +1 more source
Structural Similarity of Human and Bovine Somatomedin Receptors and Human Insulin Receptor: Analysis by Affinity Labeling [PDF]
Pediatric Research, 1981 The growth promoting and insulin-like actions of somatomedin-C (Sm-C) are thought to be mediated respectively by interactions with the Sm-C and insulin (In) receptors. Since Sm-C and In are structurally homologous, we compared the size and subunit structure of their respective radiolabeled receptors in human placental membranes (hPM) and bovine ...
S Chernausek +3 more
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