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The influence of purified somatomedins and insulin on foetal rat brain DNA synthesis in vitro
Acta Physiologica Scandinavica, 1985Gösta Enberg, V R Sara
exaly
4 Insulin and insulin-like growth factors/ somatomedins in fetal and neonatal development
Clinics in Endocrinology and Metabolism, 1984Louis E Underwood, A Joseph D'Ercole
exaly
An intact pituitary gland capable of secreting growth hormone has long been considered the prime requirement for the achievement of skeletal growth potential in man. Recent studies have revealed that the growth-promoting action of growth hormone is an in-vivo phenomenon which cannot be mimicked by the addition of the hormone to skeletal tissue in vitro.
K, Hall +3 more
core +9 more sources
Insulin-Like Growth Factors, Binding Proteins and Their Role in Pregnancy in Patients With Diabetes. [PDF]
The insulin‐like growth factor (IGF) axis, an evolutionarily conserved system, is critical in regulating cell growth, proliferation, and survival, affecting nearly all organ systems. This axis comprises two growth factors, IGF‐I and IGF‐II, and six insulin‐like growth factor–binding proteins (IGFBPs), modulating IGF activity.
Gladych-Macioszek A +5 more
europepmc +2 more sources
Delayed Bone Maturation and Extended Growth Phase as Distinctive Features of 17α-Hydroxylase/17,20-Lyase Deficiency: A Retro-Prospective Study of a Large Patient Cohort. [PDF]
ABSTRACT Introduction Worldwide, combined 17‐hydroxylase/17,20‐lyase deficiency (CYP17D) is a rare form of congenital adrenal hyperplasia, but it is the second most prevalent type in Brazil. An absence of sexual differentiation and hypergonadotropic hypogonadism arise from a reduction in the usual pattern of sex steroid formation in the adrenals and ...
Fontenele R +9 more
europepmc +2 more sources
Publisher Summary This chapter presents a personal approach to the somatomedins, from their beginnings as operationally defined activities to their emergence, in the last decade, as structural entities. The existence of other growth factors isolated from serum and tissue such as epidermal growth factor and platelet-derived growth factor are also ...
K, Hall, V R, Sara
openaire +3 more sources
Somatolactogens, Somatomedins, and Immunity
The neuroendocrine and immune systems participate as active partners in host homeostatic and defense mechanisms. This partnership involves a complex intercommunication system employing an array of shared ligands and receptors. Hormones of the somatolactogen family have marked influences on immune events in vivo, including the maintenance of lymphoid ...
S, Arkins, R, Dantzer, K W, Kelley
openaire +3 more sources
Cushing Syndrome Associated Myopathy: It Is Time for a Change [PDF]
Cushing syndrome is the result of excessive levels of glucocorticoids. Endogenous Cushing syndrome is rare with an incidence of two to three cases per million per year.
Martin Reincke
doaj +1 more source

