Results 21 to 30 of about 1,513 (164)

The Concept of Growth Hormone Deficiency Affecting Clinical Prognosis in IVF

Frontiers in Endocrinology, 2019
The current understanding of human growth hormone (hGH; here GH) action is that the molecule is a 191-amino acid, single-chain polypeptide that is synthesized, stored and secreted by the somatotroph cells within the lateral wings of the anterior ...
John L. Yovich, John L. Yovich, Sheena L. P. Regan, Sheena L. P. Regan, Syeda Zaidi, Kevin N. Keane, Kevin N. Keane   +6 more
doaj   +1 more source

Associations between serum levels of insulin-like growth factor-I and bone mineral acquisition in pubertal children: a 3-year follow-up study in Hamamatsu, Japan

Journal of Physiological Anthropology, 2019
Background Epidemiological data regarding the association between serum levels of IGF-I and bone mineral acquisition during childhood are scarce. Here, we investigated the association between serum levels of IGF-I and bone status during puberty.
Katsuyasu Kouda, Masayuki Iki, Kumiko Ohara, Harunobu Nakamura, Yuki Fujita, Toshimasa Nishiyama   +5 more
doaj   +1 more source

Blood Levels of IGF-I in Non-Small Cell Lung Cancer: Relation to Clinical Data

The International Journal of Biological Markers, 1991
Recent observations have demonstrated that somatomedins, mainly insulin-like growth factor-I (IGF-I), are growth factors for non-small cell lung cancer (NSCLC).
E. Tisi, P. Lissoni, F. Rovelli, D. Mandelli, S. Barni, G. Tancini   +5 more
doaj   +1 more source

Somatomedins/insulin-like growth factors, their receptors and binding proteins are present during mouse embryogenesis [PDF]

, 1987
Somatomedins/insulin-like growth factors (Sm/IGFs) are considered to have important roles in regulating fetal growth; however, because of limited quantities of tissue, few studies have been performed on their effects on embryonic growth.

core   +1 more source

Insulin-like growth factor-I and its binding proteins in healthy mothers and their newborns [PDF]

Einstein (São Paulo), 2004
Objective: To determine serum levels of insulin-like growth factor-I, free insulin-like growth factor-I and its binding proteins in maternalserum and in cord blood of two groups of newborns with differentbirth weights.
Rosanna Velleca Lima, Daniel Giannella Neto, Conceição Aparecida de Mattos Segre, Saul Goldenberg   +3 more
doaj  

Intact pulse cotyledon cell diet improves systemic growth via the somatotropic axis in malnourished mice

iMetaOmics, Volume 3, Issue 1, March 2026.
The MAL‐IC diet promotes growth in malnourished mice by regulating the gut microbiota—increasing the abundance of carbohydrate‐utilizing bacteria and SCFAs production. SCFAs circulate to the liver via the gut–liver axis, where they bind FFAR2 and activate the somatotropic axis, thereby stimulating GHR‐mediated GH signaling and increasing IGF‐1 and ...
Yumeng Yan, Zhuqing Xie, Zhipeng Gu, Zhongxin Li, Qiang Huang, Bin Zhang   +5 more
wiley   +1 more source

Correlation between sleep problems and morning serum melatonin and ferritin levels in Japanese 5‐year‐old children with autism spectrum disorder

Psychiatry and Clinical Neurosciences Reports, Volume 5, Issue 1, March 2026.
Abstract Aim Children with autism spectrum disorder (ASD) are more likely to have sleep problems. Few studies have investigated the relationship between sleep problems and blood melatonin and ferritin levels. The objective of this study was to determine the correlation between sleep problems and morning serum melatonin and ferritin levels, and the ...
Ai Terui, Manabu Saito, Asami Kuki, Shuji Shimoyama, Yui Sakamoto, Kazutaka Yoshida, Ayako Osato, Kazuhiko Nakamura   +7 more
wiley   +1 more source

SUSD2 Promotes Metastasis and Primary Tumor Growth in Pancreatic Cancer Cells via Integrin–FAK Signaling Activation

Cancer Science, Volume 117, Issue 3, Page 711-726, March 2026.
This study investigates the role of Sushi domain‐containing 2 (SUSD2) in pancreatic ductal adenocarcinoma (PDAC) and demonstrates that SUSD2 enhances both metastasis and primary tumor growth by promoting integrin β1–FAK signaling. SUSD2 interacts with integrin β1, enhancing adhesion to extracellular matrix (ECM) components such as collagen 1 and ...
Junjiro Yoshida, Tomokazu Ohishi, Isao Momose, Shun‐ichi Ohba, Kyohei Kurosawa, Akiko Harakawa, Hiroyuki Inoue, Minori Senoo, Daisuke Tatsuda, Hikaru Abe, Atsushi Masamune, Manabu Kawada   +11 more
wiley   +1 more source

Structural basis for uPAR binding to an antibody developed for targeted cancer therapy. Mechanistic insights into flexibility, ligand recognition, and molecular imaging

Protein Science, Volume 35, Issue 2, February 2026.
Abstract The urokinase‐type plasminogen activator receptor (uPAR) is currently gaining momentum as a promising molecular target for treatment of various solid cancers. For patient stratification, we developed a high‐affinity uPAR‐targeting peptide (AE105) detecting primary cancer lesions as well as occult metastasis by positron emission tomography (PET)
Rex F. Anane, Anni Kumari, Hari Venugopal, Sylvain Trépout, James C. Whisstock, Lars H. Engelholm, Ruby H. P. Law, Michael Ploug   +7 more
wiley   +1 more source

Differences in the Expression of Insulin‐Like Growth Factor Signaling Pathway Members in Patients With Psoriasis Vulgaris and Controls

Mediators of Inflammation, Volume 2026, Issue 1, 2026.
Insulin‐like growth factors (IGFs) and IGF–binding proteins (IGFBPs) regulate cell proliferation, differentiation, metabolic processes, and immune activities. Psoriasis is a systemic inflammatory disease with metabolic disorders as an important comorbidity in the pathogenesis of which members of the IGF family could also play a role.
Holmannova Drahomira, Borska Lenka, Fiala Zdenek, Krejsek Jan, Hamakova Kvetoslava, Cermakova Eva, Rehacek Vit, Fiala Ondrej, Maresova Tereza, Borsky Pavel, Jasbir Arora (RSS)   +10 more
wiley   +1 more source