Results 41 to 50 of about 1,398 (171)

Scale‐Dependent Rheology of Synovial Fluid Lubricating Macromolecules

open access: yesSmall, Volume 20, Issue 21, May 23, 2024.
A multiscale methodology using optical tweezers is developed to examine the interactions between hyaluronic acid (HA) and proteoglycan‐4 (PRG4/lubricin), which are major lubricating biomolecules of synovial fluid in the joints. For the first time, the length scale dependent structure and rheology in solution are characterized, providing a framework for
Leonardo Martin‐Alarcon   +6 more
wiley   +1 more source

Serum concentrations of somatomedins and growth hormone in relation to bone metabolism in acromegaly and thyroid dysfunction

open access: yes, 1986
Many hormones are involved in the complex process of formation and resorption of bone. However, only somatomedin is found to directly stimulate cell replication and collagen synthesis in bone.
Duursma, S. A., Bijlsma, J. W.
core  

Proteoglycan 4 (PRG4) treatment improves skin wound healing in a porcine model

open access: yesThe FASEB Journal, Volume 38, Issue 6, 31 March 2024.
Proteoglycan 4 (PRG4) is commonly found in synovial fluid of the articular joint and serves as a boundary lubricant of articular cartilage. Interestingly, we show that human recombinant proteoglycan 4 (rhPRG4) improves healing of porcine full‐thickness skin injuries. rhPRG4 treatment decreases fibrosis, increases vascularization, and retains adipocytes
Nicoletta Ninkovic   +5 more
wiley   +1 more source

Growth hormone resistance and somatomedins in children with end-stage liver disease awaiting transplantation

open access: yes, 1998
Background: The success of orthotopic liver transplantation as treatment for end-stage liver disease has prompted investigation of strategies to maintain or improve nutrition and growth in children awaiting transplantation, because malnutrition is an ...
Cleghorn, GJ   +7 more
core   +1 more source

Advances in the Use of Biologics and Biomaterials toward the Improvement of Pancreatic Islet Graft Survival in Type 1 Diabetes

open access: yesAdvanced NanoBiomed Research, Volume 4, Issue 3, March 2024.
Although islet transplantation has the potential to serve as a curative treatment for type 1 diabetes, there are many hurdles to achieving long‐term islet graft survival. This review discusses the recent advances in strategies to improve islet survival function using exogenous compounds and conformal coatings as a promising tool for improving islet ...
Michael Yilma Yitayew   +2 more
wiley   +1 more source

EFFECTS OF INSULIN AND INSULIN-LIKE GROWTH FACTORS ON SATELLITE CELL PROLIFERATION IN VITRO (SOMATOMEDINS, RECEPTORS).

open access: yes, 1985
Primary cultures of skeletal muscle satellite cells were induced to proliferate by exposure to physiologic levels of somatomedins and pharmacologic levels of insulin.
Dodson, Michael Verne
core  

Presence of somatomedin receptors on primary human breast and colon carcinomas

open access: yes, 2013
Competitive binding techniques were used to study the interaction of insulin-like growth factor I (IGF-I) with a plasma membrane-enriched subcellular fraction purified from primary breast and colon carcinoma specimens obtained at surgery. The presence of
Margolese, Richard G.   +4 more
core   +1 more source

Growth hormone in meat production [PDF]

open access: yes, 1989
peer reviewedThe somatotrope axis has been described in relation with the physiological effects associated with growth horone and somatomedins secretion.
Istasse, Louis   +3 more
core  

The nature of somatomedins and related peptides

open access: yes, 1978
International ...
L. van den Brande, J., van Buul, Sylvia
core   +2 more sources

Insulin-like growth factor 1 and growth hormone in chronic liver disease.

open access: yes, 1992
Somatomedins or insulin-like growth factors (IGF) are peptides synthesized in the liver. IGFs have different anabolic and metabolic actions and are important in normal growth and development.
Becker, Povl Ulrik, Møller, Søren
core  

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