Results 41 to 50 of about 1,513 (164)
Proteomic exploration of potential blood biomarkers in haemophilic arthropathy
Health Science Reports, Volume 7, Issue 9, September 2024.Abstract Background and Aims The pathophysiology of haemophilic arthropathy (HA) is complex and largely undefined. Proteomic analyses provide insights into the intricate mechanisms of the HA. Our study aimed to identify differentially expressed proteins in relation to the severity of HA, explore their pathophysiological roles, and evaluate their ...
Nataša Kalebota +13 more
wiley +1 more source
Aging Cell, Volume 23, Issue 9, September 2024.This study examined the effects of metformin (MF) and trodusquemine (MSI‐1436) on the livers of young, developing mice. We discovered that MSI‐1436 significantly alters mRNA and miRNA expression more potently than MF, impacting key metabolic pathways.
Sarah A. Ashiqueali +17 more
wiley +1 more source
Scale‐Dependent Rheology of Synovial Fluid Lubricating Macromolecules
Small, Volume 20, Issue 21, May 23, 2024.A multiscale methodology using optical tweezers is developed to examine the interactions between hyaluronic acid (HA) and proteoglycan‐4 (PRG4/lubricin), which are major lubricating biomolecules of synovial fluid in the joints. For the first time, the length scale dependent structure and rheology in solution are characterized, providing a framework for
Leonardo Martin‐Alarcon +6 more
wiley +1 more source
Proteoglycan 4 (PRG4) treatment improves skin wound healing in a porcine model
The FASEB Journal, Volume 38, Issue 6, 31 March 2024.Proteoglycan 4 (PRG4) is commonly found in synovial fluid of the articular joint and serves as a boundary lubricant of articular cartilage. Interestingly, we show that human recombinant proteoglycan 4 (rhPRG4) improves healing of porcine full‐thickness skin injuries. rhPRG4 treatment decreases fibrosis, increases vascularization, and retains adipocytes
Nicoletta Ninkovic +5 more
wiley +1 more source
, 1986 Many hormones are involved in the complex process of formation and resorption of bone. However, only somatomedin is found to directly stimulate cell replication and collagen synthesis in bone.
Duursma, S. A., Bijlsma, J. W.
core
Advanced NanoBiomed Research, Volume 4, Issue 3, March 2024.Although islet transplantation has the potential to serve as a curative treatment for type 1 diabetes, there are many hurdles to achieving long‐term islet graft survival. This review discusses the recent advances in strategies to improve islet survival function using exogenous compounds and conformal coatings as a promising tool for improving islet ...
Michael Yilma Yitayew +2 more
wiley +1 more source
Presence of somatomedin receptors on primary human breast and colon carcinomas
, 2013 Competitive binding techniques were used to study the interaction of insulin-like growth factor I (IGF-I) with a plasma membrane-enriched subcellular fraction purified from primary breast and colon carcinoma specimens obtained at surgery. The presence of
Margolese, Richard G. +4 more
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Insulin-like growth factor 1 and growth hormone in chronic liver disease.
, 1992 Somatomedins or insulin-like growth factors (IGF) are peptides synthesized in the liver. IGFs have different anabolic and metabolic actions and are important in normal growth and development.
Becker, Povl Ulrik, Møller, Søren
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, 1998 Background: The success of orthotopic liver transplantation as treatment for end-stage liver disease has prompted investigation of strategies to maintain or improve nutrition and growth in children awaiting transplantation, because malnutrition is an ...
Cleghorn, GJ +7 more
core +1 more source
The nature of somatomedins and related peptides
, 1978 International ...
J. L. VAN DEN BRANDE, Sylvia VAN BUUL
core +2 more sources