Insulin-like Growth Factor II: An Essential Adult Stem Cell Niche Constituent in Brain and Intestine [PDF]
Stem Cell Reports, 2019 Summary: Tissue-specific stem cells have unique properties and growth requirements, but a small set of juxtacrine and paracrine signals have been identified that are required across multiple niches.
Amber N. Ziegler +12 more
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Surgical resection of a retroperitoneal liposarcoma producing insulin-like growth factor II: a case report [PDF]
Surgical Case Reports, 2023 Background Tumor-produced high molecular weight insulin-like growth factor-II (big insulin-like growth factor-II) is considered to cause non-islet cell tumor hypoglycemia. This paper presents a case of surgically resected retroperitoneal liposarcoma that
Noriyuki Nishiwaki +11 more
doaj +2 more sources
Insulin-Like Growth Factor-II and Ischemic Stroke—A Prospective Observational Study [PDF]
Life, 2021 Insulin-like growth factor-II (IGF-II) regulates prenatal brain development, but the role in adult brain function and injury is unclear. Here, we determined whether serum levels of IGF-II (s-IGF-II) are associated with mortality and functional outcome ...
Daniel Åberg +7 more
doaj +2 more sources
Insulin-Like Growth Factor II [PDF]
Definitions, 2020 Insulin-like growth factor II (180 aa, ~20 kDa) is encoded by the human IGF2 gene. This protein plays a role in cellular growth, development, and mitogenesis.
semanticscholar +2 more sources
Insulin-Like Growth Factor II Targets the mTOR Pathway to Reverse Autism-Like Phenotypes in Mice. [PDF]
J Neurosci, 2018 Autism spectrum disorder (ASD) is a developmental disability characterized by impairments in social interaction and repetitive behavior, and is also associated with cognitive deficits.
Steinmetz AB +4 more
europepmc +2 more sources
Insulin-like growth factor II prevents oxidative and neuronal damage in cellular and mice models of Parkinson's disease [PDF]
Redox Biology, 2021 Oxidative distress and mitochondrial dysfunction, are key factors involved in the pathophysiology of Parkinson's disease (PD). The pleiotropic hormone insulin-like growth factor II (IGF-II) has shown neuroprotective and antioxidant effects in some ...
Elisa Martín-Montañez +13 more
doaj +2 more sources
Insulin-like Growth Factor II Prevents MPP+ and Glucocorticoid Mitochondrial-Oxidative and Neuronal Damage in Dopaminergic Neurons [PDF]
Antioxidants, 2021 Stress seems to contribute to Parkinson’s disease (PD) neuropathology, probably by dysregulation of the hypothalamic–pituitary–adrenal axis.
Silvia Claros +9 more
doaj +2 more sources
Transcriptional regulation of the IGF signaling pathway by amino acids and insulin-like growth factors during myogenesis in Atlantic salmon. [PDF]
PLoS ONE, 2010 The insulin-like growth factor signalling pathway is an important regulator of skeletal muscle growth. We examined the mRNA expression of components of the insulin-like growth factor (IGF) signalling pathway as well as Fibroblast Growth Factor 2 (FGF2 ...
Neil I Bower, Ian A Johnston
doaj +3 more sources
Association of insulin-like growth factor II mrna-binding protein 3 (IMP3) expression with prognostic and morphological factors in endometrial cancer [PDF]
Revista Brasileira de Ginecologia e ObstetríciaObjective Endometrial cancer (EC) is a heterogeneous disease with recurrence rates ranging from 15 to 20%. The discrimination of cases with a worse prognosis aims, in part, to reduce the length of surgical staging in cases with a better prognosis.
Silas Otero Reis Salum +5 more
doaj +2 more sources
Insulin-like growth factor-II: new roles for an old actor [PDF]
Frontiers in Endocrinology, 2012 IGF-II, traditionally considered as a growth factor implicated in growth of fetal tissues and cancer cells, is now emerging as a potential metabolic regulator.
Stefano eCianfarani
doaj +2 more sources