Results 31 to 40 of about 87,101 (260)
Keeping IGF-II under control: Lessons from the IGF-II–IGF2R crystal structure
Trends in Biochemical Sciences, 2009 Insulin-like growth factor-II (IGF-II) is a key regulator of cell growth, survival, migration and differentiation. Its pivotal role in these processes requires tight regulation of both expression and activity. The type 1 IGF receptor tyrosine kinase (IGF-1R) mediates IGF-II actions, and a family of six high affinity IGF binding proteins (IGFBPs ...
Brown, J., Jones, E., Forbes, B.
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Frontiers in Endocrinology, 2013 Insulin and the insulin-like growth factors (IGF)-I and –II are closely related peptides important for regulation of metabolism, growth, differentiation and development. The IGFs exert their main effects through the IGF-I receptor.
Soetkin eVersteyhe +7 more
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International Journal of Endocrinology, 2015 African American women suffer higher incidence and mortality of triple negative breast cancer (TNBC) than Caucasian women. TNBC is very aggressive, causing the worst clinical outcome.
Vinodh Kumar Radhakrishnan +5 more
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Comparative Effects of Insulin‐Like Growth Factor II (IGF‐II) and IGF‐II Mutants Specific for IGF‐II/CIM6‐P or IGF‐I Receptors on in Vitro Hematopoiesis [PDF]
STEM CELLS, 1996 This report presents the results of studies investigating the effect of insulin-like growth factor II (IGF-II) on the proliferation and differentiation of CD34+ bone marrow cells in serum-substituted liquid cultures. Bone marrow cells were enriched for CD34+ cells and then placed in liquid cultures supplemented with either interleukin 3 (IL-3) or IL-3 ...
G N, Schwartz +7 more
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Virology Journal, 2011 Hepatocellular carcinoma is mainly associated with viral hepatitis B and C. Activation of cell growth stimulator IGF-II gene is observed in tumor formation especially in viral associated hepatocellular carcinoma.
Sarwar Muhammad T +11 more
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Neurobiology of Disease, 2015 Studies have showed that prenatal cocaine exposure (PCOC) can impair cognitive function and social behavior of the offspring; however, the mechanism underlying such effect is poorly understood.
Qian Zhao +17 more
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High molecular weight forms of IGF-II ('big-IGF-II') released by Wilms' tumor cells
European Journal of Endocrinology, 1997 Insulin-like growth factor-II (IGF-II) is thought to play a critical role in the development of embryonic tumors such as Wilms' tumor. However, despite highly elevated IGF-II mRNA levels in tumors, IGF-II is not elevated in the serum of patients with Wilms' tumors. Recently high molecular weight forms of IGF-II ('big'- or pro-IGF-II) have been found to
Schmitt S +5 more
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Cellular Physiology and Biochemistry, 2018 Background/Aims: Chronic hepatitis B virus (HBV) infection (CHB) plays a central role in the etiology of hepatocellular carcinoma (HCC). Emerging evidence implicates insulin-like growth factor (IGF)-II as a major risk factor for the growth and ...
Yuanyuan Ji +5 more
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Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2014 Insulin-like growth factor-II (IGF-II) is a naturally occurring peptide that exerts known pleiotropic effects ranging from metabolic modulation to cellular development, growth and survival. IGF-II triggers its actions by binding to and activating IGF (IGF-I and IGF-II) receptors.
Martin Montañez, E. +6 more
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Refractory hypoglycemia in a patient with functional adrenal cortical carcinoma
Endocrinology, Diabetes & Metabolism Case Reports, 2016 Adrenacarcinomas are rare, and hypoglycemic syndrome resulting from the secretion of insulin-like growth factor II (IGF-II) by these tumors have been described infrequently.
Katia Regina Marchetti +3 more
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