Understanding IGF-II Action Through Insights Into Receptor Binding and Activation [PDF]
Cells, 2020 The insulin-like growth factor (IGF) system regulates metabolic and mitogenic signaling through an intricate network of related receptors and hormones. IGF-II is one of several hormones within this system that primarily regulates mitogenic functions and ...
Nicholas S Kirk +2 more
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Autocrine IGF-II-Associated Cancers: From a Rare Paraneoplastic Event to a Hallmark in Malignancy [PDF]
Biomedicines, 2023 The paraneoplastic syndrome referred in the literature as non-islet-cell tumor hypoglycemia (NICTH) and extra-pancreatic tumor hypoglycemia (EPTH) was first reported almost a century ago, and the role of cancer-secreted IGF-II in causing this blood ...
Pierluigi Scalia +6 more
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Determinants of IGF-II influencing stability, receptor binding and activation [PDF]
Scientific Reports, 2022 Insulin like growth factor II (IGF-II) is involved in metabolic and mitogenic signalling in mammalian cells and plays important roles in normal fetal development and postnatal growth.
Andrew Blyth +4 more
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Insulin-like growth factor (IGF)-II- mediated fibrosis in pathogenic lung conditions. [PDF]
PLoS ONE, 2019 Type 2 insulin-like growth factor (IGF-II) levels are increased in fibrosing lung diseases such as idiopathic pulmonary fibrosis (IPF) and scleroderma/systemic sclerosis-associated pulmonary fibrosis (SSc). Our goal was to investigate the contribution of
Sara M Garrett +4 more
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Reduced Fragmentation of IGFBP-2 and IGFBP-3 as a Potential Mechanism for Decreased Ratio of IGF-II to IGFBPs in Cerebrospinal Fluid in Response to Repeated Intrathecal Administration of Triamcinolone Acetonide in Patients With Multiple Sclerosis [PDF]
Frontiers in Endocrinology, 2021 Multiple sclerosis (MS) is a chronic autoimmune disease of the brain and spinal cord causing a wide range of symptoms such as impaired walking capability, spasticity, fatigue, and pain. The insulin-like growth factor (IGF) system has regulatory functions
Andreas Hoeflich +6 more
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Южно-Российский онкологический журнал, 2023 Purpose of the study. An analysis of IGF and their carrying proteins levels in blood serum of patients with non‑small cell lung cancer (NSCLC), depending on the severity of the previous COVID-19 infection.Materials and methods.
O. I. Kit +9 more
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Stem Cell Research & Therapy, 2020 Background Parthenogenetic stem cells (PSCs) are a promising source of regenerated cardiomyocytes; however, their application may be limited without a paternal genome.
Yi Sui +8 more
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Redox Biology, 2021 Oxidative distress and mitochondrial dysfunction, are key factors involved in the pathophysiology of Parkinson's disease (PD). The pleiotropic hormone insulin-like growth factor II (IGF-II) has shown neuroprotective and antioxidant effects in some ...
Elisa Martín-Montañez +13 more
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Kangaroo IGF-II is structurally and functionally similar to the human [Ser29]-IGF-II variant [PDF]
Journal of Endocrinology, 1999 Abstract Kangaroo IGF-II has been purified from western grey kangaroo (Macropus fuliginosus) serum and characterised in a number of in vitro assays. In addition, the complete cDNA sequence of mature IGF-II has been obtained by reverse-transcription polymerase chain reaction.
C A, Yandell +3 more
openaire +2 more sources
Insulin-like growth factors: Ligands, binding proteins, and receptors
Molecular Metabolism, 2021 Background: The insulin-like growth factor family of ligands (IGF-I, IGF-II, and insulin), receptors (IGF-IR, M6P/IGF-IIR, and insulin receptor [IR]), and IGF-binding proteins (IGFBP-1-6) play critical roles in normal human physiology and disease states.
Derek LeRoith +2 more
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