Results 11 to 20 of about 5,200,432 (243)

Involvement of IGF-II receptors in the antioxidant and neuroprotective effects of IGF-II on adult cortical neuronal cultures

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2014
Insulin-like growth factor-II (IGF-II) is a naturally occurring peptide that exerts known pleiotropic effects ranging from metabolic modulation to cellular development, growth and survival. IGF-II triggers its actions by binding to and activating IGF (IGF-I and IGF-II) receptors.
Martin Montañez, E., Pavia, J., Santin, L. J., BORALDI, Federica, Estivill Torrus, G., Aguirre, J. A., Garcia Fernandez, M.   +6 more
openaire   +4 more sources

Reduced Fragmentation of IGFBP-2 and IGFBP-3 as a Potential Mechanism for Decreased Ratio of IGF-II to IGFBPs in Cerebrospinal Fluid in Response to Repeated Intrathecal Administration of Triamcinolone Acetonide in Patients With Multiple Sclerosis [PDF]

Frontiers in Endocrinology, 2021
Multiple sclerosis (MS) is a chronic autoimmune disease of the brain and spinal cord causing a wide range of symptoms such as impaired walking capability, spasticity, fatigue, and pain. The insulin-like growth factor (IGF) system has regulatory functions
Andreas Hoeflich, Brit Fitzner, Christina Walz, Michael Hecker, Armin Tuchscherer, Julia Brenmoehl, Uwe Klaus Zettl   +6 more
doaj   +2 more sources

The impact of a human IGF-II analog ([Leu27]IGF-II) on fetal growth in a mouse model of fetal growth restriction. [PDF]

Am J Physiol Endocrinol Metab, 2016
Enhancing placental insulin-like growth factor (IGF) availability appears to be an attractive strategy for improving outcomes in fetal growth restriction (FGR).
Charnock JC, Dilworth MR, Aplin JD, Sibley CP, Westwood M, Crocker IP.   +5 more
europepmc   +3 more sources

Hepatoprotection and neuroprotection induced by low doses of IGF-II in aging rats

Journal of Translational Medicine, 2011
Background GH and IGFs serum levels decline with age. Age-related changes appear to be associated to decreases in these anabolic hormones. We have previously demonstrated that IGF-I replacement therapy improves insulin resistance, lipid metabolism and ...
Barhoum Rima, Sierra Inma, Puche Juan E, Delgado Gloria, García-Fernández María, Castilla-Cortázar Inma, González-Barón Salvador   +6 more
doaj   +2 more sources

Nucleotide sequences of cDNAs encoding precursors of human insulin‐like growth factor II (IGF‐II) and an IGF‐II variant

FEBS Letters, 1985
We have isolated 3 cDNA clones encoding human IGF‐II and a variant of IGF‐II. The amino acid sequence encoded by the IGF‐II cDNA is identical to the sequence previously described [(1978) FEBS Lett. 89, 283‐286]. In the amino acid sequence predicted by the IGF‐II variant cDNA, the Ser residue 29 in the B‐domain has been replaced by an Arg‐Leu‐Pro‐Gly ...
Jansen, M., van Schaik, P.M.A., van Tol, H., Van den Brande, J.L., Sussenbach, J.S.   +4 more
openaire   +3 more sources

Insulin-like growth factor II prevents oxidative and neuronal damage in cellular and mice models of Parkinson's disease

Redox Biology, 2021
Oxidative distress and mitochondrial dysfunction, are key factors involved in the pathophysiology of Parkinson's disease (PD). The pleiotropic hormone insulin-like growth factor II (IGF-II) has shown neuroprotective and antioxidant effects in some ...
Elisa Martín-Montañez, Nadia Valverde, David Ladrón de Guevara-Miranda, Estrella Lara, Yanina S. Romero-Zerbo, Carmelo Millon, Federica Boraldi, Fabiola Ávila-Gámiz, Ana M. Pérez-Cano, Pablo Garrido-Gil, Jose Luis Labandeira-Garcia, Luis J. Santin, Jose Pavia, Maria Garcia-Fernandez   +13 more
doaj   +1 more source

Insulin-like growth factor-II overexpression accelerates parthenogenetic stem cell differentiation into cardiomyocytes and improves cardiac function after acute myocardial infarction in mice

Stem Cell Research & Therapy, 2020
Background Parthenogenetic stem cells (PSCs) are a promising source of regenerated cardiomyocytes; however, their application may be limited without a paternal genome.
Yi Sui, Wei Zhang, Tao Tang, Lili Gao, Ting Cao, Hongbo Zhu, Qinghua You, Bo Yu, Tao Yang   +8 more
doaj   +1 more source

Insulin-Like Growth Factor I Receptor (IGF-IR) Ligands and BMI in Squamous Intra-Epithelial Lesion (SIL) of Cervix [PDF]

Journal of Clinical and Diagnostic Research, 2016
Introduction: Cancer cervix is the most common cancer in women in developing countries like India. Several studies have linked insulin-like growth factors-I & II (IGF-I and IGF-II) and IGF binding proteins-3 (IGFBP-3) with pathogenesis of Squamous ...
Praveen Sablania, Swaraj Batra, Alpana Saxena   +2 more
doaj   +1 more source

Varying severity COVID-19 effects on the blood indicators of insulin-like growth factors family in patients with nonsmall cell lung cancer

Южно-Российский онкологический журнал, 2023
Purpose of the study. An analysis of IGF and their carrying proteins levels in blood serum of patients with non‑small cell lung cancer (NSCLC), depending on the severity of the previous COVID-19 infection.Materials and methods.
O. I. Kit, E. M. Frantsiyants, D. A. Kharagezov, V. A. Bandovkina, N. D. Cheryarina, Yu. A. Pogorelova, Yu. N. Lazutin, A. G. Milakin, I. A. Leyman, O. N. Stateshny   +9 more
doaj   +1 more source

The Soluble Type 2 Insulin-like Growth Factor (IGF-II) Receptor Reduces Organ Size by IGF-II-mediated and IGF-II-independent Mechanisms [PDF]

Journal of Biological Chemistry, 1998
The soluble type 2 insulin-like growth factor (IGF) receptor or IGF-II/mannose 6-phosphate receptor (sIGF2R) is produced in vivo by proteolytic deletion of the transmembrane and intracellular domains of the cellular form of the receptor (IGF2R). There is evidence that sIGF2R is a negative regulator of growth.
S, Zaina, S, Squire
openaire   +2 more sources