Results 21 to 30 of about 87,101 (260)

Insulin-Like Growth Factor I Receptor (IGF-IR) Ligands and BMI in Squamous Intra-Epithelial Lesion (SIL) of Cervix [PDF]

Journal of Clinical and Diagnostic Research, 2016
Introduction: Cancer cervix is the most common cancer in women in developing countries like India. Several studies have linked insulin-like growth factors-I & II (IGF-I and IGF-II) and IGF binding proteins-3 (IGFBP-3) with pathogenesis of Squamous ...
Praveen Sablania, Swaraj Batra, Alpana Saxena   +2 more
doaj   +1 more source

Eating in an extreme environment: diet of the European hare (Lepus europaeus) on Vesuvius

The European Zoological Journal, 2022
The European hare (Lepus europaeus) is cosmopolitan species, living in a variety of habitats and showing a diversified diet, that has been described mainly from agricultural meadows and crops, with little information available for extreme environments ...
M. Buglione, G. de Filippo, P. Conti, D. Fulgione   +3 more
doaj   +1 more source

The Soluble Type 2 Insulin-like Growth Factor (IGF-II) Receptor Reduces Organ Size by IGF-II-mediated and IGF-II-independent Mechanisms [PDF]

Journal of Biological Chemistry, 1998
The soluble type 2 insulin-like growth factor (IGF) receptor or IGF-II/mannose 6-phosphate receptor (sIGF2R) is produced in vivo by proteolytic deletion of the transmembrane and intracellular domains of the cellular form of the receptor (IGF2R). There is evidence that sIGF2R is a negative regulator of growth.
S, Zaina, S, Squire
openaire   +2 more sources

IGF-II promotes neuroprotection and neuroplasticity recovery in a long-lasting model of oxidative damage induced by glucocorticoids

Redox Biology, 2017
Insulin-like growth factor-II (IGF-II) is a naturally occurring hormone that exerts neurotrophic and neuroprotective properties in a wide range of neurodegenerative diseases and ageing.
E. Martín-Montañez, C. Millon, F. Boraldi, F. Garcia-Guirado, C. Pedraza, E. Lara, L.J. Santin, J. Pavia, M. Garcia-Fernandez   +8 more
doaj   +1 more source

Extreme Hypoglycaemia in Anaplastic Large Cell Lymphoma

European Journal of Case Reports in Internal Medicine, 2017
Introduction: Hypoglycaemia associated with non-islet cell tumours (NICTH) is a rare entity in patients with extra-pancreatic malignancies, mostly attributed to large mesenchymal or epithelial tumours.
Lidor Akavia, Ilan Krauze
doaj   +1 more source

CLINICAL IMPLICATIONS OF INSULIN-LIKE GROWTH FACTORS (IGF) AND IGF-BINDING PROTEINS INVESTIGATION IN PATIENTS WITH OVARIAN NEOPLASMS

Alʹmanah Kliničeskoj Mediciny, 2016
Background: The insulin-like growth factor (IGF) signaling system plays a major role in development and progression of various malignancies including ovarian cancer, and its components are considered as potential diagnostic and prognostic markers and the
E. S. Gershteyn, D. N. Kushlinskiy, E. A. Korotkova, E. R. Isaeva, V. D. Ermilova, K. P. Laktionov, L. V. Adamyan, N. E. Kushlinskii   +7 more
doaj   +1 more source

Re-expression of IGF-II is important for beta cell regeneration in adult mice. [PDF]

PLoS ONE, 2012
The key factors which support re-expansion of beta cell numbers after injury are largely unknown. Insulin-like growth factor II (IGF-II) plays a critical role in supporting cell division and differentiation during ontogeny but its role in the adult is ...
Luxian Zhou, Stella Pelengaris, Sylvie Abouna, James Young, David Epstein, Julia Herold, Tim Wilhelm Nattkemper, Hassan Nakhai, Michael Khan   +8 more
doaj   +1 more source

IGF-II Promotes Mesoderm Formation

Developmental Biology, 2000
IGF-II is abundant in the nascent mesoderm of the gastrulating mouse embryo. Its function at this developmental stage is unknown. We investigated it by following the in vitro and in vivo differentiation of several androgenetic, biparental, parthenogenetic, and androgenetic Igf2 -/- murine ES cell lines; these cells differed in endogenous IGF-II levels ...
Morali, Olivier G., Jouneau, Alice, McLaughlin, K.John, Thiery, Jean Paul, Larue, Lionel   +4 more
openaire   +2 more sources

Fluorescent IGF-II analogues for FRET-based investigations into the binding of IGF-II to the IGF-1R

Organic & Biomolecular Chemistry, 2016
Convergent-based synthesis of native IGF-II and two IGF-II analogues, with coumarin fluorescent probes incorporated at residues 19 and 28, and their use in FRET-based identification of interactions with the type 1 insulin-like growth factor receptor (IGF-IR).
Cottam Jones, Jade M, Harris, Paul William Richard, Scanlon, Denis B, Forbes, Briony E, Brimble, Margaret Anne, Abell, Andrew D   +5 more
openaire   +4 more sources

Characteristics of Hepatic IGF-II Expression and Monitored Levels of Circulating IGF-II mRNA in Metastasis of Hepatocellular Carcinoma [PDF]

American Journal of Clinical Pathology, 2010
Abstract The prognosis of hepatocellular carcinoma (HCC) remains dismal. Insulin-like growth factor II (IGF-II), a fetal growth factor, is highly expressed during HCC development. We examined serum IGF-II levels and circulating IGF-II messenger RNA (mRNA) expression and analyzed the clinicopathologic characteristics in patients with ...
Jing, Qian, Dengfu, Yao, Zhizhen, Dong, Wei, Wu, Liwei, Qiu, Ninghua, Yao, Shanshan, Li, Yinzhu, Bian, Zhiwei, Wang, Gongsheng, Shi   +9 more
openaire   +2 more sources