A critical role for IGF-II in memory consolidation and enhancement
Nature, 2011 We report that, in the rat, administering insulin-like growth factor II (IGF-II, also known as IGF2) significantly enhances memory retention and prevents forgetting.
Dillon Y. Chen +7 more
semanticscholar +1 more source
Assessing the role of insulin-like growth factors and binding proteins in prostate cancer using Mendelian randomization:genetic variants as instruments for circulating levels [PDF]
, 2016 Circulating insulin-like growth factors (IGFs) and their binding proteins (IGFBPs) are associated with prostate cancer. Using genetic variants as instruments for IGF peptides, we investigated whether these associations are likely to be causal.
Amin Al Olama +46 more
core +4 more sources
IGF-II is regulated by microRNA-125b in skeletal myogenesis
Journal of Cell Biology, 2011 miR-125b is identified as a myogenic miRNA that regulates skeletal muscle differentiation by targeting IGF-II under the control of mTOR signaling.
Yejing Ge, Yuting Sun, Jie Chen
semanticscholar +1 more source
Association Between Cytokines and Liver Histology in Children with Nonalcoholic Fatty Liver Disease. [PDF]
, 2017 BackgroundReliable non-invasive markers to characterize inflammation, hepatocellular ballooning, and fibrosis in nonalcoholic fatty liver disease (NAFLD) are lacking.
Ann Scheimann +14 more
core +1 more source
Characterization of IGF-II isoforms in binge eating disorder and its group psychological treatment. [PDF]
PLoS ONE, 2013 Binge eating disorder (BED) affects 3.5% of the population and is characterized by binge eating for at least 2 days a week for 6 months. Treatment options include cognitive behavioral therapy, interpersonal psychotherapy, and pharmacotherapy which are ...
Giorgio Tasca +9 more
doaj +1 more source
Cumulative mutagenesis of the basic residues in the 201-218 region of insulin-like growth factor (IGF)-binding protein-5 results in progressive loss of both IGF-I binding and inhibition of IGF-I biological action [PDF]
, 2005 We have reported previously that mutation of two conserved nonbasic amino acids (G203 and Q209) within the highly basic 201–218 region in the C-terminal domain of IGF-binding protein-5 (IGFBP-5) decreases binding to IGFs.
Andress +40 more
core +1 more source
Neurología (English Edition), 2014 Introduction: Many studies have demonstrated that iron deficiency modifies the normal function of the central nervous system (CNS) and alters cognitive abilities.
E. Morales González +2 more
doaj +1 more source
Influence of L-carnitine on litter characteristics from gilts harvested at day 40, 55, and 70 of gestation [PDF]
, 2005 Swine research, 2005 is known as Swine day, 2005A total of 59 gilts were used to determine the effects of supplemental L-carnitine on reproductive performance. Experimental treatments were arranged in a 2 × 3 factorial with main effects of L-carnitine (0
Brazle, A.E. +12 more
core +2 more sources
Lectin-induced alterations of the interaction of insulin and insulin-like growth factor 1 receptors with their ligands [PDF]
Journal of the Serbian Chemical Society, 2008 In order to study whether the carbohydrate moieties of the human placental IGF-I receptor (IGF1R), IGF-II receptor (IGF2R) and insulin receptors (IRs) play a role in ligand binding, solubilised cell membrane preparations were incubated with 125I-labelled
Masnikosa Romana +2 more
doaj +3 more sources
IGF-II Producing Hepatic Fibrosarcoma Associated with Hypoglycemia.
Internal Medicine, 1993 A 67-year-old male was admitted with the complaint of weakness at hunger early in the morning, when blood glucose was less than 40 mg/dl. The abdominal ultrasonogram and computerized tomogram demonstrated a huge tumor in the right liver lobe. Hypoglycemia disappeared after transcatheter arterial embolization. Then hepatic lobectomy was performed.
Ko KOTANI +10 more
openaire +3 more sources