Results 71 to 80 of about 87,101 (260)

Understanding and Mitigating the Risk of Accelerated Biological Aging in Survivors of Cancer: A Scoping Review

Aging and Cancer, EarlyView.
Cancer treatment is associated with measurable acceleration of biological aging across epigenetic, telomere, senescence, and immune biomarkers. However, biomarker validation and interventional strategies remain limited, especially in hematologic malignancies, underscoring the need for standardized multi‐omic aging assessments and adequately powered ...
Moataz Ellithi, Emily Herdman, Danielle Westmark, Vijaya R. Bhatt   +3 more
wiley   +1 more source

Hepatoprotection and neuroprotection induced by low doses of IGF-II in aging rats

Journal of Translational Medicine, 2011
Background GH and IGFs serum levels decline with age. Age-related changes appear to be associated to decreases in these anabolic hormones. We have previously demonstrated that IGF-I replacement therapy improves insulin resistance, lipid metabolism and ...
Barhoum Rima, Sierra Inma, Puche Juan E, Delgado Gloria, García-Fernández María, Castilla-Cortázar Inma, González-Barón Salvador   +6 more
doaj   +1 more source

Dysregulated Cholesterol Metabolism, Chronic Inflammation, and Disability in Severe Progressive Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Dysregulated lipid metabolism, which can affect remyelination and neural repair, has not been extensively investigated in progressive multiple sclerosis (PMS). The goal was to examine whether dysregulated cholesterol metabolism was associated with disability in PMS. Methods The study sample comprised 53 Severe PMS patients (Expanded
Taylor R. Wicks, Mujeeb Shittu, Anna Wolska, Diala Ghazal, Bianca Weinstock‐Guttman, Alexander Burnham, Alan T. Remaley, Robert Zivadinov, Murali Ramanathan   +8 more
wiley   +1 more source

A novel insulin-like growth factor II-based masking domain for conditional activation of therapeutic antibodies

mAbs
Systemic target engagement constrains the therapeutic index of many antibody drugs, particularly in inflammatory disease and immuno-oncology. Protease-cleavable masking can localize activity to disease sites, but existing approaches often tradeoff ...
Lihua Shi, Minseon Cho, Motohiko Nishida, Mark L. Chiu, Di Zhang   +4 more
doaj   +1 more source

Refractory hypoglycemia induced by a duodenal wall gastrointestinal stromal tumor: A case report

Caspian Journal of Internal Medicine, 2021
Background: Tumor-associated hypoglycemia can be caused by non-islet cell tumors including gastrointestinal stromal tumor (GIST) which is a rare paraneoplastic syndrome that leads to the release of insulin-like growth factor-2 (IGF-2). Case Presentation:
Foolad Eghbali, Reza Karami
doaj  

Fabrication Routes for Ionic Conducting Fiber Strain Sensors

Advanced Engineering Materials, EarlyView.
Ionic conducting fiber strain sensors (ICFSs) offer compliant, textile‐integrable sensing. Thus far, the commercialization of ICFSs has been constrained by fiber fabrication routes. This review provides a fabrication‐centric analysis of ICFSs correlating processing strategies with material properties and scalability.
Leo John Kershaw, Zhanhong Yang, Anne Ladegaard Skov, Magdalena Skowyra   +3 more
wiley   +1 more source

Zmiany w stężeniach insulinopodobnych czynników wzrostu IGF-1 i IGF-2 i białek wiążących BP-2 i BP-3 w czasie leczenia ostrej białaczki limfoblastycznej [PDF]

Pediatric Endocrinology, Diabetes and Metabolism, 2004
Cel pracy: Ocena dynamiki zmian w wartościach insulinopodobnych czynników wzrostu: IGF-1 i IGF-2 i białek wiążących: IGFBP-2 i IGFBP-3 w surowicy krwi dzieci z ostrą białaczką limfoblastyczną (ALL) w trakcie leczenia przeciwnowotworowego.
Maryna Krawczuk-Rybak, Anna Kitszel, Sławomir Wołczyński   +2 more
doaj  

Self‐Healing Hydrogel‐Enabled Modular Assembly of Bilayered Skin Construct for Hair Follicle Regeneration

Advanced Healthcare Materials, EarlyView.
Self‐healing assembly of two cell‐laden hydrogel layers creates a biomimetic skin construct that restores both dermal and epidermal functions, resulting in accelerated wound healing and enhanced hair follicle regeneration in a full‐thickness skin wound model. ABSTRACT Alopecia remains a pervasive clinical challenge, largely owing to the limited ability
JaeWook Park, Su Yong Kim, MinSu Jeong, Beom Joon Kim, Shin Hyuk Kang, Won‐Gun Koh   +5 more
wiley   +1 more source

Immunohistochemical localization of IGF-I, IGF-II and MSTN proteins during development of triploid sea bass (Dicentrarchus labrax)

European Journal of Histochemistry, 2010
The cellular localization of IGF-I, IGF-II and MSTN proteins was investigated during ontogenesis of triploid sea bass (Dicentrarchus labrax) by an immunohistochemical approach. The results were compared with those observed in diploids.
G. Radaelli, C. Poltronieri, C. Simontacchi, E. Negrato, F. Pascoli, A. Libertini, D. Bertotto   +6 more
doaj   +3 more sources

Insulin-like growth factor family and prostate cancer: new insights and emerging opportunities

Frontiers in Endocrinology
Prostate cancer is the second most commonly diagnosed cancer in men. The mammalian insulin-like growth factor (IGF) family is made up of three ligands (IGF-I, IGF-II, and insulin), three receptors (IGF-I receptor (IGF-1R), insulin receptor (IR), and IGF ...
Noha M. Elemam, Noha M. Elemam, Hassan Youssef Hotait, Mohamed A. Saleh, Mohamed A. Saleh, Mohamed A. Saleh, Waseem El-Huneidi, Waseem El-Huneidi, Iman M. Talaat, Iman M. Talaat, Iman M. Talaat   +10 more
doaj   +1 more source