Distinct organ-specific up- and down-regulation of IGF-I and IGF-II mRNA in various organs of a GH-overexpressing transgenic Nile tilapia [PDF]
, 2018 Several lines of GH-overexpressing fish have been produced and characterized concerning organ integrity, growth, fertility and health but few and contradictory data are available on IGF-I that mediates most effects of GH. Furthermore, nothing is known on
Berishvili, Giorgi +6 more
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Ligand-binding affinity at the insulin receptor isoform-A and subsequent IR-A tyrosine phosphorylation kinetics are important determinants of mitogenic biological outcomes [PDF]
, 2015 Copyright: © 2015 Rajapaksha and Forbes. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).
Forbes, Briony E, Rajapaksha, H
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The International Journal of Biological Markers, 2002 Recent in situ hybridization experiments have shown a high content of IGF-II mRNA in breast cancer stroma. The aim of this study was to examine the relationship between IGF-II protein expression and several prognostic parameters in 75 infiltrating ductal
C. Giani +7 more
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Association of Circulating Insulin-like Growth Factors and IGF Binding Protein with Early Cases of Cancer Cervix [PDF]
Journal of Clinical and Diagnostic Research, 2018 Introduction: Insulin-like Growth Factor (IGF) signaling pathway has important roles in regulating cellular proliferation, apoptosis, differentiation and transformation.
Praveen Sablania +2 more
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A meta-analysis of individual participant data reveals an association between circulating levels of IGF-I and prostate cancer risk [PDF]
, 2016 The role of insulin-like growth factors (IGF) in prostate cancer development is not fully understood. To investigate the association between circulating concentrations of IGFs (IGF-I, IGF-II, IGFBP-1, IGFBP-2, and IGFBP-3) and prostate cancer risk, we ...
Albanes, Demetrius +50 more
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European Journal of Histochemistry, 2010 The cellular localization of IGF-I, IGF-II and MSTN proteins was investigated during ontogenesis of triploid sea bass (Dicentrarchus labrax) by an immunohistochemical approach. The results were compared with those observed in diploids.
G. Radaelli +6 more
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Genetic factors and insulin secretion: gene variants in the IGF genes [PDF]
, 2004 IGFs are important regulators of pancreatic beta-cell development, growth, and maintenance. Mutations in the IGF genes have been found to be associated with type 2 diabetes, myocardial infarction, birth weight, and obesity.
Dekker, J.M. (Jacqueline) +11 more
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Insulin-like growth factors and related proteins in plasma and cerebrospinal fluids of HIV-positive individuals. [PDF]
, 2015 BackgroundClinically significant dysregulation of the insulin-like growth factor (IGF) family proteins occurs in HIV-infected individuals, but the details including whether the deficiencies in IGFs contribute to CNS dysfunction are unknown.MethodsWe ...
Choi, Namjong +4 more
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Nucleic Acids Research, 1992 The human insulin-like growth factor II (IGF-II) gene constitutes a complex transcriptional unit that contains nine exons and four promoters. Expression of the IGF-II gene yields a family of mRNAs that all encode prepro-IGF-II. In addition, a stable 1.8 kb RNA is formed that is derived from the 3' untranslated region of exon 9.
Meinsma, D. +4 more
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IGFBP-5 regulates muscle cell differentiation by binding to IGF-II and switching on the IGF-II auto-regulation loop [PDF]
The Journal of Cell Biology, 2008 IGF-II stimulates both mitogenesis and myogenesis through its binding and activation of the IGF-I receptor (IGF-IR). How this growth factor pathway promotes these two opposite cellular responses is not well understood. We investigate whether local IGF binding protein-5 (IGFBP-5) promotes the myogenic action of IGF-II.
Ren, Hongxia, Yin, Ping, Duan, Cunming
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