Insulin-like growth factor family and prostate cancer: new insights and emerging opportunities
Frontiers in EndocrinologyProstate cancer is the second most commonly diagnosed cancer in men. The mammalian insulin-like growth factor (IGF) family is made up of three ligands (IGF-I, IGF-II, and insulin), three receptors (IGF-I receptor (IGF-1R), insulin receptor (IR), and IGF ...
Noha M. Elemam +10 more
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Российский офтальмологический журнал, 2018 Studying immunological aspects of pathogenesis of retinopathy of prematurity (ROP) helps develop new approaches to prevention, rational diagnosis and increase of the effectiveness of treatment of the disease.
L. A. Katargina +3 more
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A méhen belüli növekedési visszamaradás genetikai háttere; kölcsönhatás egyéb etiológiai faktorokkal [PDF]
, 2015 It has been recognized that Intrauterine Growth Restriction (IUGR) is commonly due to placental dysfunction associated with both genetic and environmental factors. Nonetheless, the molecular mechanism of IUGR remains largely unexplored.
Börzsönyi, Balázs
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The Intrathymic Expression of Insulin-Related Genes: Implications for Pathophysiology and Prevention of Type 1 Diabetes [PDF]
, 1998 peer reviewedRecent experimental work has challenged and shattered the old concept of a sequestration of pancreatic islet antigens from developing T-cells within the thymic environment.
Geenen, Vincent, Lefebvre, Pierre J.
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Reproductive Biology and Endocrinology, 2003 Testis tumors occur frequently in dogs. The main types of tumors are Sertoli cell tumors, seminomas, and Leydig cell tumors. Mixed tumors and bilateral occurrence of tumors may be encountered frequently. To elucidate the possible relationship between the
Oosterlaken-Dijksterhuis Marja A +5 more
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Journal of Biological Chemistry, 1991 Five mutants of recombinant insulin-like growth factor-II (rIGF-II) that bound with high affinity to either the IGF-II/cation-independent mannose 6-phosphate (IGF-II/CIM6-P) or the IGF-I receptor were prepared by site-directed mutagenic procedures ...
K. Sakano +8 more
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Refractory hypoglycemia induced by a duodenal wall gastrointestinal stromal tumor: A case report
Caspian Journal of Internal Medicine, 2021 Background: Tumor-associated hypoglycemia can be caused by non-islet cell tumors including gastrointestinal stromal tumor (GIST) which is a rare paraneoplastic syndrome that leads to the release of insulin-like growth factor-2 (IGF-2). Case Presentation:
Foolad Eghbali, Reza Karami
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Liver mitochondrial dysfunction is reverted by insulin-like growth factor II (IGF-II) in aging rats
Journal of Translational Medicine, 2011 Background Serum IGF-I and IGF-II levels decline with age. IGF-I replacement therapy reduces the impact of age in rats. We have recently reported that IGF-II is able to act, in part, as an analogous of IGF-I in aging rats reducing oxidative damage in ...
Castilla-Cortazar Inma +4 more
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Differential Effects of Insulin-Like Growth Factor Binding Protein-6 (IGFBP-6) on Migration of Two Ovarian Cancer Cell Lines [PDF]
, 2015 Introduction: IGFBP-6 inhibits angiogenesis as well as proliferation and survival of rhabdomyosarcoma cells. However, it promotes migration of these cells in an IGF-independent manner.
Leon A. Bach, Zhiyong Yang
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High-affinity prorenin binding to cardiac man-6-P/IGF-II receptors precedes proteolytic activation to renin [PDF]
, 2001 Mannose-6-phosphate (man-6-P)/insulin-like growth factor-II (man-6-P/IgF-II) receptors are involved in the activation of recombinant human prorenin by cardiomyocytes.
Bruin, R.J.A. (René) de +7 more
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