Results 61 to 70 of about 87,101 (260)

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Where the wolf roams: ecological preferences and wild prey association in a changing Mediterranean landscape

Frontiers in Zoology
The wolf (Canis lupus) is a species of great conservation interest and has recently highlighted management challenges throughout Europe. Over the past 50 years, the establishment of National Parks, forest cover changes as well as the expansion of wild ...
Maria Buglione, Domenico Fulgione, Tiziano Trasmondo, Benedetta De Francesco, Gabriele de Filippo, Eleonora Rivieccio   +5 more
doaj   +1 more source

New aspects of immunopathogenesis of retinopathy of prematurity: the role of TGF-β1 and IGF-II in pathological vascularization of the retina

Российский офтальмологический журнал, 2018
Studying immunological aspects of pathogenesis of retinopathy of prematurity (ROP) helps develop new approaches to prevention, rational diagnosis and increase of the effectiveness of treatment of the disease.
L. A. Katargina, O. S. Slepova, E. N. Demchenko, N. A. Osipova   +3 more
doaj   +1 more source

The impact of a human IGF-II analog ([Leu27]IGF-II) on fetal growth in a mouse model of fetal growth restriction. [PDF]

Am J Physiol Endocrinol Metab, 2016
Enhancing placental insulin-like growth factor (IGF) availability appears to be an attractive strategy for improving outcomes in fetal growth restriction (FGR). Our approach was the novel use of [Leu27]IGF-II, a human IGF-II analog that binds the IGF-II clearance receptor IGF-IIR in fetal growth-restricted (FGR) mice.
Charnock JC, Dilworth MR, Aplin JD, Sibley CP, Westwood M, Crocker IP.   +5 more
europepmc   +5 more sources

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Association of Elevated IGFBP-1 with Increased IGF-II Concentration in Patients with Carcinoma of the Liver

The International Journal of Biological Markers, 2008
Insulin-like growth factors (IGFs) are mitogens for numerous types of cells including cancer cells. The aim of this work was to analyze some of the components of the IGF system to assess which could be potential clinical biomarkers for monitoring ...
O. Nedić, V. Malenković, B. Đukanović, I. Baričević   +3 more
doaj   +1 more source

Association of Circulating Insulin-like Growth Factors and IGF Binding Protein with Early Cases of Cancer Cervix [PDF]

Journal of Clinical and Diagnostic Research, 2018
Introduction: Insulin-like Growth Factor (IGF) signaling pathway has important roles in regulating cellular proliferation, apoptosis, differentiation and transformation.
Praveen Sablania, Montosh Chakraborty, Debajit Bagchi   +2 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Insulin-Like Growth Factor II (IGF-II) Immunohistochemistry in Breast Cancer: Relationship with the Most Important Morphological and Biochemical Prognostic Parameters

The International Journal of Biological Markers, 2002
Recent in situ hybridization experiments have shown a high content of IGF-II mRNA in breast cancer stroma. The aim of this study was to examine the relationship between IGF-II protein expression and several prognostic parameters in 75 infiltrating ductal
C. Giani, D. Campani, A. Rasmussen, P. Fierabracci, P. Miccoli, G. Bevilacqua, A. Pinchera, K.J. Cullen   +7 more
doaj   +1 more source

IGF-II Promotes Stemness of Neural Restricted Precursors [PDF]

Stem Cells, 2012
Abstract Insulin-like growth factor (IGF)-I and IGF-II regulate brain development and growth through the IGF type 1 receptor (IGF-1R). Less appreciated is that IGF-II, but not IGF-I, activates a splice variant of the insulin receptor (IR) known as IR-A.
Amber N, Ziegler, Joel S, Schneider, Mei, Qin, William A, Tyler, John E, Pintar, Diego, Fraidenraich, Teresa L, Wood, Steven W, Levison   +7 more
openaire   +2 more sources