Results 1 to 10 of about 156,997 (300)
Poultry Science, 2022 : We investigated the expression of insulin-like growth factor 1 (IGF-1) and IGF-1 type 1 receptor (IGF-1R) in skeletal muscle fiber types in chickens with hepatic fibrosis induced by bile duct ligation (BDL).
J. Nagasao +11 more
doaj +3 more sources
Deficiency in type 1 insulin-like growth factor receptor in mice protects against oxygen-induced lung injury [PDF]
Respiratory Research, 2005 Background Cellular responses to aging and oxidative stress are regulated by type 1 insulin-like growth factor receptor (IGF-1R). Oxidant injury, which is implicated in the pathophysiology of a number of respiratory diseases, acutely upregulates IGF-1R ...
Flejou Jean-François +7 more
doaj +7 more sources
IGF-1 regulates Cyr61 induced breast cancer cell proliferation and invasion. [PDF]
, 2014 BackgroundStudies from our laboratory and others have shown that cysteine-rich 61 (Cyr61) may be involved in tumor proliferation and invasion. In earlier studies, we demonstrated increased insulin-like growth factor-I (IGF-1) is associated with breast ...
Cardenas, Jessica +5 more
core +16 more sources
Regulation of Id2 Gene Expression by the Type 1 IGF Receptor and the Insulin Receptor Substrate-1 [PDF]
Endocrinology, 2001 The Id family of helix-loop-helix proteins is known to be involved in the proliferation and differentiation of several types of cells. The type 1 IGF receptor (IGF-IR) induces either proliferation or differentiation in 32D cells, a murine hemopoietic cell line, depending on the availability of the appropriate substrates for the receptor.
M, Navarro +5 more
openaire +3 more sources
Does reduced IGF-1R signaling in Igf1r+/- mice alter aging? [PDF]
PLoS ONE, 2011 Mutations in insulin/IGF-1 signaling pathway have been shown to lead to increased longevity in various invertebrate models. Therefore, the effect of the haplo-insufficiency of the IGF-1 receptor (Igf1r(+/-)) on longevity/aging was evaluated in C57Bl/6 ...
Alex F Bokov +11 more
doaj +1 more source
Expression of mRNA encoding IGF-I, IGF-II and type 1 IGF receptor in bovine ovarian follicles [PDF]
Journal of Endocrinology, 2000 IGFs regulate gonadotrophin-stimulated proliferation and differentiation of granulosa and theca cells in vitro. However, the detailed pattern of mRNA expression of IGFs in bovine follicles remains controversial. The objectives of this study were therefore to describe the temporal and spatial pattern of expression of mRNA encoding IGF-I, IGF-II and the ...
D G, Armstrong +7 more
openaire +2 more sources
IGF-IR internalizes with Caveolin-1 and PTRF/Cavin in HaCat cells. [PDF]
PLoS ONE, 2010 BACKGROUND:Insulin-like growth factor-I receptor (IGF-IR) is a tyrosine kinase receptor (RTK) associated with caveolae, invaginations of the plasma membrane that regulate vesicular transport, endocytosis and intracellular signaling.
Barbara Salani +7 more
doaj +1 more source
IGF Type 1 Receptor: A Cell Cycle Progression Factor That Regulates Aging [PDF]
Cell Cycle, 2003 International ...
Dupont, Joëlle, Holzenberger, M.
openaire +3 more sources
Role of ubiquitination in IGF-1 receptor signaling and degradation. [PDF]
PLoS ONE, 2007 BACKGROUND: The insulin-like growth factor 1 receptor (IGF-1R) plays numerous crucial roles in cancer biology. The majority of knowledge on IGF-1R signaling is concerned with its role in the activation of the canonical phosphatidyl inositol-3 kinase ...
Bita Sehat +4 more
doaj +1 more source
Defective insulin secretion in pancreatic β cells lacking type 1 IGF receptor [PDF]
Journal of Clinical Investigation, 2002 Defective insulin secretion is a feature of type 2 diabetes that results from inadequate compensatory increase of beta cell mass and impaired glucose-dependent insulin release. beta cell proliferation and secretion are thought to be regulated by signaling through receptor tyrosine kinases.
Xuan, Shouhong +11 more
openaire +3 more sources