Results 1 to 10 of about 89,239 (242)

Evaluation of a novel hexavalent humanized anti-IGF-1R antibody and its bivalent parental IgG in diverse cancer cell lines. [PDF]

PLoS ONE, 2012
A major mechanism of monoclonal antibodies that selectively target the insulin-like growth factor type 1 receptor (IGF-1R) to inhibit tumor growth is by downregulating the receptor, regardless whether they are capable (antagonistic) or incapable ...
Chien-Hsing Chang, Yang Wang, Preeti Trisal, Rongxiu Li, Diane L Rossi, Anju Nair, Pankaj Gupta, Michele Losman, Thomas M Cardillo, Edmund A Rossi, David M Goldenberg   +10 more
doaj   +1 more source

A Twenty-First Century Cancer Epidemic Caused by Obesity: The Involvement of Insulin, Diabetes, and Insulin-Like Growth Factors

International Journal of Endocrinology, 2013
Obesity has reached epidemic proportions in the developed world. The progression from obesity to diabetes mellitus type 2, via metabolic syndrome, is recognised, and the significant associated increase in the risk of major human cancers acknowledged.
Rosalyne L. Westley, Felicity E. B. May
doaj   +1 more source

Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r)

Cell, 1993
Newborn mice homozygous for a targeted disruption of insulin-like growth factor gene (Igf-1) exhibit a growth deficiency similar in severity to that previously observed in viable Igf-2 null mutants (60% of normal birthweight). Depending on genetic background, some of the Igf-1(-/-) dwarfs die shortly after birth, while others survive and reach ...
J P, Liu, J, Baker, A S, Perkins, E J, Robertson, A, Efstratiadis   +4 more
openaire   +2 more sources

Correlations between IGF-IR Expression and Clinicopathological Factors and Prognosis in Patients with Lung Adenocarcinoma

Chinese Journal of Lung Cancer, 2010
Background and objective The incidence of lung adenocarcinoma increases rapidly, and IGF-IR is the key mediator of several growth factors signal transduction, therefore it plays an important role in the proliferation and differentiation of cancer cell ...
Xueyan ZHANG, Jiuxian FENG, Huifang SHA, Jinsu HUANG, Baohui HAN   +4 more
doaj  

The tobacco-specific carcinogen NNK induces pulmonary tumorigenesis via nAChR/Src/STAT3-mediated activation of the renin-angiotensin system and IGF-1R signaling

Experimental and Molecular Medicine, 2023
The renin-angiotensin (RA) system has been implicated in lung tumorigenesis without detailed mechanistic elucidation. Here, we demonstrate that exposure to the representative tobacco-specific carcinogen nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1 ...
Hye-Jin Boo, Hye-Young Min, Su Jung Hwang, Hyo-Jong Lee, Jae-Won Lee, Sei-Ryang Oh, Choon-Sik Park, Jong-Sook Park, You Mie Lee, Ho-Young Lee   +9 more
doaj   +1 more source

Insulin Receptor Substrate Adaptor Proteins Mediate Prognostic Gene Expression Profiles in Breast Cancer.

PLoS ONE, 2016
Therapies targeting the type I insulin-like growth factor receptor (IGF-1R) have not been developed with predictive biomarkers to identify tumors with receptor activation.
Marc A Becker, Yasir H Ibrahim, Annabell S Oh, Dedra H Fagan, Sara A Byron, Aaron L Sarver, Adrian V Lee, Leslie M Shaw, Cheng Fan, Charles M Perou, Douglas Yee   +10 more
doaj   +1 more source

Insulin-Like Growth Factor Binding Protein-5 in Physiology and Disease

Frontiers in Endocrinology, 2020
Insulin-like growth factor (IGF) signaling is regulated by a conserved family of IGF binding proteins (IGFBPs) in vertebrates. Among the six distinct types of IGFBPs, IGFBP-5 is the most highly conserved across species and has the broadest range of ...
Cunming Duan, John B. Allard
doaj   +1 more source

Androgen receptor overexpression in prostate cancer in type 2 diabetes

Molecular Metabolism, 2018
Objective: While prostate cancer does not occur more often in men with diabetes, survival is markedly reduced in this patient group. Androgen signaling is a known and major driver for prostate cancer progression.
Stefan Zoltán Lutz, Jörg Hennenlotter, Marcus Oliver Scharpf, Corinna Sailer, Louise Fritsche, Vera Schmid, Konstantinos Kantartzis, Robert Wagner, Rainer Lehmann, Lucia Berti, Andreas Peter, Harald Staiger, Andreas Fritsche, Falko Fend, Tilman Todenhöfer, Arnulf Stenzl, Hans-Ulrich Häring, Martin Heni   +17 more
doaj   +1 more source

The impact of the IGF-1 system of cancer cells on radiation response – An in vitro study

Clinical and Translational Radiation Oncology, 2017
Background: Overexpression of the insulin-like growth factor-1 receptor (IGF-1R) is associated with increased cell proliferation, differentiation, transformation, and tumorigenicity.
Senthiladipan Venkatachalam, Esther Mettler, Christian Fottner, Matthias Miederer, Bernd Kaina, Matthias M. Weber   +5 more
doaj   +1 more source

The C Region of Human Insulin-like Growth Factor (IGF) I Is Required for High Affinity Binding to the Type 1 IGF Receptor

Journal of Biological Chemistry, 1989
We have produced and characterized the binding properties of three structural analogs of human insulin-like growth factor I (hIGF-I). These analogs are [1-62]hIGF-I, an analog lacking the carboxyl-terminal 8-amino acid D region of hIGF-I; [1-27, Gly4, 38-70]hIGF-I, an analog in which residues 28-37 of the C region of hIGF-I are replaced by a 4-reside ...
M L, Bayne, J, Applebaum, D, Underwood, G G, Chicchi, B G, Green, N S, Hayes, M A, Cascieri   +6 more
openaire   +2 more sources