Results 11 to 20 of about 89,239 (242)
Poultry Science, 2022 : We investigated the expression of insulin-like growth factor 1 (IGF-1) and IGF-1 type 1 receptor (IGF-1R) in skeletal muscle fiber types in chickens with hepatic fibrosis induced by bile duct ligation (BDL).
J. Nagasao +11 more
doaj +3 more sources
Regulation of Id2 Gene Expression by the Type 1 IGF Receptor and the Insulin Receptor Substrate-1 [PDF]
Endocrinology, 2001 The Id family of helix-loop-helix proteins is known to be involved in the proliferation and differentiation of several types of cells. The type 1 IGF receptor (IGF-IR) induces either proliferation or differentiation in 32D cells, a murine hemopoietic cell line, depending on the availability of the appropriate substrates for the receptor.
M, Navarro +5 more
openaire +3 more sources
Does reduced IGF-1R signaling in Igf1r+/- mice alter aging? [PDF]
PLoS ONE, 2011 Mutations in insulin/IGF-1 signaling pathway have been shown to lead to increased longevity in various invertebrate models. Therefore, the effect of the haplo-insufficiency of the IGF-1 receptor (Igf1r(+/-)) on longevity/aging was evaluated in C57Bl/6 ...
Alex F Bokov +11 more
doaj +1 more source
IGF-IR internalizes with Caveolin-1 and PTRF/Cavin in HaCat cells. [PDF]
PLoS ONE, 2010 BACKGROUND:Insulin-like growth factor-I receptor (IGF-IR) is a tyrosine kinase receptor (RTK) associated with caveolae, invaginations of the plasma membrane that regulate vesicular transport, endocytosis and intracellular signaling.
Barbara Salani +7 more
doaj +1 more source
Role of ubiquitination in IGF-1 receptor signaling and degradation. [PDF]
PLoS ONE, 2007 BACKGROUND: The insulin-like growth factor 1 receptor (IGF-1R) plays numerous crucial roles in cancer biology. The majority of knowledge on IGF-1R signaling is concerned with its role in the activation of the canonical phosphatidyl inositol-3 kinase ...
Bita Sehat +4 more
doaj +1 more source
Expression of mRNA encoding IGF-I, IGF-II and type 1 IGF receptor in bovine ovarian follicles [PDF]
Journal of Endocrinology, 2000 IGFs regulate gonadotrophin-stimulated proliferation and differentiation of granulosa and theca cells in vitro. However, the detailed pattern of mRNA expression of IGFs in bovine follicles remains controversial. The objectives of this study were therefore to describe the temporal and spatial pattern of expression of mRNA encoding IGF-I, IGF-II and the ...
D G, Armstrong +7 more
openaire +2 more sources
Scientific Reports, 2021 Insulin-like Growth Factor-1 (IGF-1) is involved in the normal development and survival of retinal cells. Low-density lipoprotein Receptor-related Protein-1 (LRP1) plays a key role on the regulation of several membrane proteins, such as the IGF-1 ...
Virginia Actis Dato +2 more
doaj +1 more source
Membrane-associated insulin-like growth factor (IGF) binding structures in placental cells [PDF]
Journal of the Serbian Chemical Society, 2003 The biological activities of IGF-I and –II are mediated mainly by the type 1 IGF receptor (IGF 1R) and controlled by their interaction with soluble proteins, the IGF binding proteins (IGFBPs). Although there is a growing body of evidence that some IGFBPs
Masnikosa Romana M. +2 more
doaj +3 more sources
IGF Type 1 Receptor: A Cell Cycle Progression Factor That Regulates Aging [PDF]
Cell Cycle, 2003 International ...
Dupont, Joëlle, Holzenberger, M.
openaire +3 more sources
PACAP type I receptor transactivation is essential for IGF‐1 receptor signalling and antiapoptotic activity in neurons [PDF]
The EMBO Journal, 2007 Insulin-like growth factor-1 (IGF-1) and pituitary adenylyl cyclase activating polypeptide (PACAP) are both potent neurotrophic and antiapoptotic factors, which exert their effects via phosphorylation cascades initiated by tyrosine kinase and G-protein-coupled receptors, respectively. Here, we have adapted a recently described phosphoproteomic approach
Nicolas, Delcourt +6 more
openaire +4 more sources