Results 21 to 30 of about 89,239 (242)

The IGF/Insulin-IGFBP Axis in Corneal Development, Wound Healing, and Disease

Frontiers in Endocrinology, 2020
The insulin-like growth factor (IGF) family plays key roles in growth and development. In the cornea, IGF family members have been implicated in proliferation, differentiation, and migration, critical events that maintain a smooth refracting surface that
Whitney L. Stuard, Rossella Titone, Danielle M. Robertson   +2 more
doaj   +1 more source

Therapeutic Targeting of the IGF Axis

Cells, 2019
The insulin like growth factor (IGF) axis plays a fundamental role in normal growth and development, and when deregulated makes an important contribution to disease.
Eliot Osher, Valentine M. Macaulay
doaj   +1 more source

The Role of Insulin and Insulin-like Growth Factors in the Increased Risk of Cancer in Diabetes

Rambam Maimonides Medical Journal, 2011
Patients with type 2 diabetes (T2D) are at increased risk of developing cancer. This evidence arises from numerous epidemiologic studies that relate a positive association between T2D and cancer. In-vitro and several in-vivo experiments have attempted to
Derek LeRoith, Eyal J. Scheinman, Keren Bitton-Worms   +2 more
doaj   +1 more source

Intervertebral disc degeneration in mice with type II diabetes induced by leptin receptor deficiency

BMC Musculoskeletal Disorders, 2020
Background The leptin receptor-deficient knockout (db/db) mouse is a well-established model for studying type II diabetes mellitus (T2DM). T2DM is an important risk factor of intervertebral disc degeneration (IVDD). Although the relationship between type
Xinhua Li, Xiaoming Liu, Yiru Wang, Fuming Cao, Zhaoxiong Chen, Zhouyang Hu, Bin Yu, Hang Feng, Zhaoyu Ba, Tao Liu, Haoxi Li, Bei Jiang, Yufeng Huang, Lijun Li, Desheng Wu   +14 more
doaj   +1 more source

Identification of a Resistance Mechanism to IGF-IR Targeting in Human Triple Negative MDA-MB-231 Breast Cancer Cells

Biomolecules, 2021
Triple negative breast cancer (TNBC) is associated with unfavorable prognosis and high relapse rates following chemotherapy. There is an urgent need to develop effective targeted therapy for this BC subtype. The type I insulin-like growth factor receptor
Jennifer Tsui, Shu Qi, Stephanie Perrino, Matthew Leibovitch, Pnina Brodt   +4 more
doaj   +1 more source

Defective insulin secretion in pancreatic β cells lacking type 1 IGF receptor [PDF]

Journal of Clinical Investigation, 2002
Defective insulin secretion is a feature of type 2 diabetes that results from inadequate compensatory increase of beta cell mass and impaired glucose-dependent insulin release. beta cell proliferation and secretion are thought to be regulated by signaling through receptor tyrosine kinases.
Xuan, Shouhong, Kitamura, Tadahiro, Nakae, Jun, Politi, Katerina, Kido, Yoshiaki, Fisher, P. E., Morroni, Manrico, Cinti, Saverio, White, M. F., Herrera, Pedro Luis, Accili, Domenico, Efstratiadis, Argiris   +11 more
openaire   +2 more sources

The EGF receptor interacts with the type 1 IGF receptor and regulates its stability

Biochemical and Biophysical Research Communications, 2007
Both the epidermal growth factor receptor (EGFR) and type 1 insulin-like growth factor receptor (IGF1R) require homo- and hetero-dimerisation with their own family members to acquire full function. We recently showed that IGF1R gene silencing led to EGFR hyper-phosphorylation in human breast cancer cells, and hypothesised that this crosstalk might be ...
Riedemann, J, Takiguchi, M, Sohail, M, Macaulay, V   +3 more
openaire   +2 more sources

Insulin-like growth factor (IGF)-II- mediated fibrosis in pathogenic lung conditions.

PLoS ONE, 2019
Type 2 insulin-like growth factor (IGF-II) levels are increased in fibrosing lung diseases such as idiopathic pulmonary fibrosis (IPF) and scleroderma/systemic sclerosis-associated pulmonary fibrosis (SSc). Our goal was to investigate the contribution of
Sara M Garrett, Eileen Hsu, Justin M Thomas, Joseph M Pilewski, Carol Feghali-Bostwick   +4 more
doaj   +1 more source

Determinants of IGF-II influencing stability, receptor binding and activation

Scientific Reports, 2022
Insulin like growth factor II (IGF-II) is involved in metabolic and mitogenic signalling in mammalian cells and plays important roles in normal fetal development and postnatal growth.
Andrew Blyth, Michael Ortiz, Allanah Merriman, Carlie Delaine, Briony Forbes   +4 more
doaj   +1 more source

Radioresistant laryngeal cancers upregulate type 1 IGF receptor and exhibit increased cellular dependence on IGF and EGF signalling [PDF]

Clinical Otolaryngology, 2019
AbstractObjectivesPatients failing radiotherapy for laryngeal squamous cell carcinoma (LSCC) often require salvage total laryngectomy which has major functional consequences, highlighting a need for biomarkers of radiotherapy resistance. In other tumour types, radioresistance has been linked to epidermal growth factor receptor (EGFR) and type 1 insulin‐
Ali Qureishi, Guillaume Rieunier, Ketan A. Shah, Tamara Aleksic, Stuart C. Winter, Henrik Møller, Valentine M. Macaulay   +6 more
openaire   +3 more sources