Results 21 to 30 of about 156,997 (300)

PACAP type I receptor transactivation is essential for IGF‐1 receptor signalling and antiapoptotic activity in neurons [PDF]

The EMBO Journal, 2007
Insulin-like growth factor-1 (IGF-1) and pituitary adenylyl cyclase activating polypeptide (PACAP) are both potent neurotrophic and antiapoptotic factors, which exert their effects via phosphorylation cascades initiated by tyrosine kinase and G-protein-coupled receptors, respectively. Here, we have adapted a recently described phosphoproteomic approach
Nicolas, Delcourt, Eric, Thouvenot, Benjamin, Chanrion, Nathalie, Galéotti, Patrick, Jouin, Joël, Bockaert, Philippe, Marin   +6 more
  +6 more sources

The Role of Insulin and Insulin-like Growth Factors in the Increased Risk of Cancer in Diabetes

Rambam Maimonides Medical Journal, 2011
Patients with type 2 diabetes (T2D) are at increased risk of developing cancer. This evidence arises from numerous epidemiologic studies that relate a positive association between T2D and cancer. In-vitro and several in-vivo experiments have attempted to
Derek LeRoith, Eyal J. Scheinman, Keren Bitton-Worms   +2 more
doaj   +1 more source

Intervertebral disc degeneration in mice with type II diabetes induced by leptin receptor deficiency

BMC Musculoskeletal Disorders, 2020
Background The leptin receptor-deficient knockout (db/db) mouse is a well-established model for studying type II diabetes mellitus (T2DM). T2DM is an important risk factor of intervertebral disc degeneration (IVDD). Although the relationship between type
Xinhua Li, Xiaoming Liu, Yiru Wang, Fuming Cao, Zhaoxiong Chen, Zhouyang Hu, Bin Yu, Hang Feng, Zhaoyu Ba, Tao Liu, Haoxi Li, Bei Jiang, Yufeng Huang, Lijun Li, Desheng Wu   +14 more
doaj   +1 more source

Des(1–3)IGF‐1 Treatment Normalizes Type 1 IGF Receptor and Phospho‐Akt (Thr 308) Immunoreactivityin Predegenerative Retina of Diabetic Rats [PDF]

Journal of Diabetes Research, 2003
Little is known about interventions that may prevent predegenerative changes in the diabetic retina. This study tested the hypothesis that immediate, systemic treatment with an insulin‐like growth factor (IGF)‐1 analog can prevent abnormal accumulations of type 1 IGF receptor, and phospho‐Akt (Thr 308) immunoreactivity in predegenerative retinas of ...
Kummer, A., Pulford, B. E., Ishii, D. N., Seigel, G. M.   +3 more
openaire   +2 more sources

Fluorescent IGF-II analogues for FRET-based investigations into the binding of IGF-II to the IGF-1R [PDF]

, 2016
This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material.The interaction of IGF-II ...
Abell, Andrew D, Brimble, Margaret Anne, Cottam Jones, Jade M, Forbes, Briony E, Harris, Paul William Richard, Scanlon, Denis B   +5 more
core   +1 more source

How IGF-II Binds to the Human Type 1 Insulin-like Growth Factor Receptor [PDF]

Structure, 2020
Human type 1 insulin-like growth factor receptor (IGF-1R) signals chiefly in response to the binding of insulin-like growth factor I. Relatively little is known about the role of insulin-like growth factor II signaling via IGF-1R, despite the affinity of insulin-like growth factor II for IGF-1R being within an order of magnitude of that of insulin-like
Xu, Y, Kirk, NS, Venugopal, H, Margetts, MB, Croll, TI, Sandow, JJ, Webb, AI, Delaine, CA, Forbes, BE, Lawrence, MC   +9 more
openaire   +3 more sources

Identification of a Resistance Mechanism to IGF-IR Targeting in Human Triple Negative MDA-MB-231 Breast Cancer Cells

Biomolecules, 2021
Triple negative breast cancer (TNBC) is associated with unfavorable prognosis and high relapse rates following chemotherapy. There is an urgent need to develop effective targeted therapy for this BC subtype. The type I insulin-like growth factor receptor
Jennifer Tsui, Shu Qi, Stephanie Perrino, Matthew Leibovitch, Pnina Brodt   +4 more
doaj   +1 more source

Novel Role of the IGF-1 Receptor in Endothelial Function and Repair: Studies in Endothelium-Targeted IGF-1 Receptor Transgenic Mice [PDF]

, 2012
We recently demonstrated that reducing IGF-1 receptor (IGF-1R) numbers in the endothelium enhances nitric oxide (NO) bioavailability and endothelial cell insulin sensitivity.
A. Abbas, A. Skromna, Booth, Bredt, Chen, Cubbon, D. J. Beech, De Meyts, Federici, Fulton, Gatenby, GUILLOT, H. Imrie, H. Viswambharan, J. Smith, Jiang, K. M. Channon, Kubota, Li, M. Gage, M. T. Kearney, N. Yuldasheva, Nakagawa, P. J. Grant, P. Sukumar, R. M. Cubbon, Razani, S. B. Wheatcroft, S. Galloway, S. T. Rashid, S. Xuan, Schleicher, Stegmayr, T. S. Futers, V. K. Gatenby, Vicent, Wheatcroft   +36 more
core   +1 more source

Reversal of age-related learning deficiency by the vertebrate PACAP and IGF-1 in a novel invertebrate model of aging: the pond snail (Lymnaea Stagnalis) [PDF]

, 2014
With the increase of life span, nonpathological age-related memory decline is affecting an increasing number of people. However, there is evidence that age-associated memory impairment only suspends, rather than irreversibly extinguishes, the intrinsic ...
Alexander, Audesirk, Chaudhury, D. Regl di, Delcourt, Du, G. Kemenes, Hattiangady, Hermann, Hernadi, I. Kemenes, J  zsa, Kemenes, Kemenes, Lee, Markowska, Otto, Otto, Patel, Patel, Pavlopoulos, Pirger, Pirger, Pirger, Roberto, S. Naskar, Sacchetti, Shioda, Silhol, Tamas, Telegdy, Vaudry, Watson, Watson, Yang, Yeoman, Z. Laszlo, Z. Pirger, Zhang   +38 more
core   +2 more sources

Insulin-like growth factor (IGF)-II- mediated fibrosis in pathogenic lung conditions.

PLoS ONE, 2019
Type 2 insulin-like growth factor (IGF-II) levels are increased in fibrosing lung diseases such as idiopathic pulmonary fibrosis (IPF) and scleroderma/systemic sclerosis-associated pulmonary fibrosis (SSc). Our goal was to investigate the contribution of
Sara M Garrett, Eileen Hsu, Justin M Thomas, Joseph M Pilewski, Carol Feghali-Bostwick   +4 more
doaj   +1 more source