IGF-1 receptor regulates dynamic changes in neuronal polarity during cerebral cortical migration
Scientific Reports, 2017 During cortical development, neurons undergo polarization, oriented migration and layer-type differentiation. The biological and biochemical mechanisms underlying these processes are not completely understood.
Alvaro F. Nieto Guil +6 more
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Insulin-Like Growth Factor (IGF) Signaling through Type 1 IGF Receptor Plays an Important Role in Remyelination [PDF]
The Journal of Neuroscience, 2003 We examined the role of IGF signaling in the remyelination process by disrupting the gene encoding the type 1 IGF receptor (IGF1R) specifically in the mouse brain by Cre-mediated recombination and then exposing these mutants and normal siblings to cuprizone.
Jeffrey L, Mason +4 more
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The effects of type 1 IGF receptor inhibition in a mouse model of diabetic kidney disease [PDF]
Growth Hormone & IGF Research, 2011 We have recently shown increased sensitivity to IGF-I induced signal transduction in kidneys of diabetic mice. Accordingly we investigated the effects of PQ401, a novel diarylurea compound that inhibits IGF1R autophosphorylation in type I diabetes.Control (C) and Diabetic (D) mice were administered PQ401 (CP, DP) or vehicle (C, D) for 3weeks.CP animals
Ariel, Troib +5 more
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How IGF-II Binds to the Human Type 1 Insulin-like Growth Factor Receptor [PDF]
Structure, 2020 Human type 1 insulin-like growth factor receptor (IGF-1R) signals chiefly in response to the binding of insulin-like growth factor I. Relatively little is known about the role of insulin-like growth factor II signaling via IGF-1R, despite the affinity of insulin-like growth factor II for IGF-1R being within an order of magnitude of that of insulin-like
Xu, Y +9 more
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Zinc partitions IGFs from soluble IGF binding proteins (IGFBP)-5, but not soluble IGFBP-4, to myoblast IGF type 1 receptors [PDF]
Journal of Endocrinology, 2004 Zinc (Zn(2+)), a multifunctional micronutrient, was recently shown to lower the affinity of cell-associated insulin-like growth factor (IGF) binding protein (IGFBP)-3 and IGFBP-5 for both IGF-I and IGF-II, but to increase the affinity of the cell surface type 1 IGF receptor (IGF-1R) for the same two ligands. However, there is a need for data concerning
R H, McCusker, J, Novakofski
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CLINICAL AND HORMONAL MILIEU OF 9 PATIENTS WITH PRIMARY GROWTH HORMONE INSENSITIVITY SYNDROME AND THEIR RESPONSE TO IGF-I GENERATION TEST [PDF]
Acta Medica Iranica, 2006 Primary growth hormone insensitivity syndrome (GHIS) is a rare entity which can be due to defects in growth hormone (GH) receptor that is called type 1 Laron syndrome (T1LS) or post receptor defects (type 2 Laron syndrome ).
M. Razzaghy-Azar +1 more
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How ligand binds to the type 1 insulin-like growth factor receptor
Nature Communications, 2018 The human type 1 insulin-like growth factor receptor (IGF-1R) is important for normal human growth and development. Here, the authors present the crystal structures of the IGF-1R ectodomain both in its apo form and in complex with its ligand insulin-like
Yibin Xu +9 more
doaj +1 more source
Angiotensin II receptor blocker attenuates intrarenal renin-angiotensin-system and podocyte injury in rats with myocardial infarction. [PDF]
PLoS ONE, 2013 The mechanisms and mediators underlying common renal impairment after myocardial infarction (MI) are still poorly understood. The present study aimed to test the hypothesis that angiotensin II type 1 receptor blockers (ARBs) provides renoprotective ...
Zhu-zhi Wen +7 more
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American Society of Clinical Oncology Educational Book, 2012 Overview: Increased signaling of the insulin-like growth factor (IGF) system via alterations in expression levels of its components has been demonstrated in various tumor types. Numerous experimental studies have supported the involvement of the IGF system signaling axis in tumor initiation and progression.
Scotlandi, Katia, Belfiore, Antonino
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Des(1–3)IGF‐1 Treatment Normalizes Type 1 IGF Receptor and Phospho‐Akt (Thr 308) Immunoreactivityin Predegenerative Retina of Diabetic Rats [PDF]
Journal of Diabetes Research, 2003 Little is known about interventions that may prevent predegenerative changes in the diabetic retina. This study tested the hypothesis that immediate, systemic treatment with an insulin‐like growth factor (IGF)‐1 analog can prevent abnormal accumulations of type 1 IGF receptor, and phospho‐Akt (Thr 308) immunoreactivity in predegenerative retinas of ...
Kummer, A. +3 more
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