Results 181 to 190 of about 19,264 (196)
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Advances of IGF-1R inhibitors in Graves’ ophthalmopathy
International OphthalmologyGraves' ophthalmopathy is the most common extra-thyroidal organ manifestation of Graves' disease. The mainstay of clinical treatment is glucocorticoids; however, side effects and relapse are common problems, and current treatment options cannot alter the disease progression.
Meilan, Wang, Lian, Liu
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Crosstalk between IGF-1R and other Tumor Promoting Pathways
Current Pharmaceutical Design, 2014Insulin-like growth factor 1 receptor (IGF-1R) is important in cancer pathogenesis and progression. While its signaling pathway is an interesting therapeutic target, recent clinical trials have exhibited limited effects; however, significant crosstalks between IGF- 1R and other signaling pathways have garnered increasing attention.
Changyu, Liu +5 more
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Pathology - Research and Practice, 2019
Hepatocellular carcinoma (HCC) is among the most frequently observed forms of cancer. MicroRNAs (miRNAs) are increasingly thought to play a key role in regulating the onset and progression of a wide range of cancer types. In the present report, we found that miR-455-5p expression was significantly decreased in both HCC patient tumor tissues and cell ...
Yiren, Hu +4 more
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Hepatocellular carcinoma (HCC) is among the most frequently observed forms of cancer. MicroRNAs (miRNAs) are increasingly thought to play a key role in regulating the onset and progression of a wide range of cancer types. In the present report, we found that miR-455-5p expression was significantly decreased in both HCC patient tumor tissues and cell ...
Yiren, Hu +4 more
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Mouse Models of IGF-1R and Cancer
2011A variety of systems have been used to evaluate the role of the insulin-like growth factor (IGF) axis in cancer, including human tissue and serum, cell lines derived from spontaneous tumors from humans and other species, and genetically modified animals.
Craig I. Campbell +2 more
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Cancer Research, 2010
Abstract Background: Lung cancer is the commonest cause of cancer related deaths worldwide and has a very poor prognosis Recent evidence indicates that epidermal growth factor receptor (EGFR) and insulin-like growth factor receptor 1 (IGF-1R) interact in the pathogenesis of malignant epithelial tumours including lung cancer.
Lydia Forde +5 more
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Abstract Background: Lung cancer is the commonest cause of cancer related deaths worldwide and has a very poor prognosis Recent evidence indicates that epidermal growth factor receptor (EGFR) and insulin-like growth factor receptor 1 (IGF-1R) interact in the pathogenesis of malignant epithelial tumours including lung cancer.
Lydia Forde +5 more
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Inhibitory effect of siRNA targeting IGF-1R on endometrial carcinoma
International Immunopharmacology, 2011The type-1 insulin-like growth factor receptor (IGF-1R) is one member of tyrosine protein kinase receptor family. It is a causal factor for tumor initiation, development and frequently overactivated in a variety of human malignancies, including endometrial carcinoma.
Shanrong, Shu +6 more
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IGF-1R targeted treatment of sarcoma
The Lancet Oncology, 2010Jeffrey A Toretsky, Richard Gorlick
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Inhibition de IGF-1R et sarcomes
Bulletin du Cancer, 2010Christophe Massard, Jean-Yves Blay
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IGF-1R inhibition: right direction, wrong pathway?
The Lancet Oncology, 2013Sheridan, Wilson, Stephen K, Chia
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