Results 151 to 160 of about 115,801 (264)

Somapacitan in Children Born SGA: 52-Week Efficacy, Safety, and IGF-I Response Results From the Phase 2 REAL5 Study. [PDF]

J Clin Endocrinol Metab
Juul A, Backeljauw P, Højby M, Frystyk J, Kawai M, Kildemoes RJ, Lemminger AK, Linglart A, Zuckerman-Levin N, Horikawa R.   +9 more
europepmc   +1 more source

EE2 and the Fish Brain: Age‐Dependent Impact of 17α‐Ethinylestradiol on Brain Cell Proliferation and Behavior in Sea Bass Larvae

Environmental Toxicology, EarlyView.
ABSTRACT Endocrine‐disrupting chemicals (EDCs), such as 17α‐ethinylestradiol (EE2), have raised concerns about their potential effects on aquatic organisms, particularly during early developmental stages. In this context, the study of behavioral disruption has gained considerable attention, as it may have consequences on individual fitness and ...
Soloperto Sofia, Stephanie Olivier, Céline Thomasse, Christophe Minier, Marie‐Pierre Halm‐Lemeille, Christelle Jozet‐Alves, Salima Aroua   +6 more
wiley   +1 more source

Therapeutic potential for mRNA-based IGF-I regenerative therapy. [PDF]

Mol Ther Nucleic Acids
Anderson CD.
europepmc   +1 more source

PPM1G‒MET axis sustains AKT signaling to drive Twist‐associated EMT and drug resistance in hepatocellular carcinoma

VIEW, EarlyView.
Hepatocellular carcinoma (HCC) is frequently resistant to targeted therapies. We identify protein phosphatase Mg2+/Mn2+‐dependent 1G (PPM1G) as a key phosphatase that stabilizes mesenchymal‐epithelial transition factor (MET) by inhibiting its ubiquitination, thereby sustaining protein kinase B (AKT) signaling and promoting Twist‐mediated epithelial ...
Weixun Wu, Songbin Lin, Cong Zhou, Jinwu Hu, Kun Liu, Yongfeng Xu, Zhenbin Ding, Mengting Luo, Bo Hu   +8 more
wiley   +1 more source

Plasma Proteomics Analysis Identifying IGFBP2 as a Potential Diagnostic Biomarker for Laryngeal Squamous Cell Carcinoma

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Objective Currently, there are no blood biomarkers available for the early diagnosis of laryngeal squamous cell carcinoma (LSCC). The objective of this study was to search for potential plasma biomarkers for the diagnosis of LSCC. Methods Plasma samples were taken from patients with LSCC and healthy controls for proteomic analysis.
Shuang Teng, Ling‐Mei Qu, Jun‐Jie Liu, Yu‐Shan Li, Zi‐Qi Chen, Shuo Liu, Zhao‐Nan Xu, Meng Jin, Qiu‐Ying Li, Qin Wu, Hong‐Tian Yi, Xian‐Ji Shen, Bing‐Rui Yan, Ya‐Nan Sun   +13 more
wiley   +1 more source

Plasma insulin‐like growth‐factor 1 (IGF‐1) concentrations predict early life‐history traits in a wild mammal

Functional Ecology, EarlyView.
Read the free Plain Language Summary for this article on the Journal blog. Abstract The hormone insulin‐like growth factor 1 (IGF‐1) is a key player in the insulin/IGF signalling (IIS) pathway. Extensive biogerontological research demonstrates that this evolutionarily conserved nutrient‐sensing pathway plays a causal role in the regulation of growth ...
Sanjana Ravindran, Yolanda Corripio‐Miyar, Joel L. Pick, Xavier Bal, Jill G. Pilkington, Josephine M. Pemberton, Daniel H. Nussey, Hannah Froy   +7 more
wiley   +1 more source

TcALS knockdown accelerates metamorphosis via insulin signaling in Tribolium castaneum

Insect Science, EarlyView.
RNAi silencing of TcALS accelerates larva‐to‐pupa metamorphosis in Tribolium castaneum. Abstract Insect metamorphosis is an evolutionary adaptation precisely regulated by nutritional and hormonal cues. The red flour beetle Tribolium castaneum, a major stored‐product pest, serves as an excellent model for studying this process.
Min Li, Jie Chen, Zi‐Ye Wang, Fei‐Feng Wang, Lu‐Lu Dong, Jun Pan, Min‐Er Li, Lin Yu, Wen Sang   +8 more
wiley   +1 more source

Sharing the Same Playground? An Analysis of the Private Sector's Role in Tech Diplomacy

Global Policy, EarlyView.
ABSTRACT This article takes the emergence of tech diplomacy as the motivation for an investigation into shifting relationships between traditional diplomatic actors and non‐state actors. The observation that ‘new diplomatic actors’ and new diplomatic venues have led to a ‘new kind of diplomacy’ dates back to at least the 1990s.
Katharina E. Höne
wiley   +1 more source

Tales of Cyberspace and Artificial Intelligence: Diverging Stakeholderships?

Global Policy, EarlyView.
ABSTRACT This article traces the evolution of the Internet from the 1990s to the 2020s and compares it with the development of Artificial Intelligence (AI), particularly following the public launch of ChatGPT in late 2022. It identifies both parallels and divergencies between these two overlapping technological domains, focusing on the growing ...
Johan Eriksson, Giampiero Giacomello
wiley   +1 more source

Correction to: "Loss-of-Function GHSR Variants Are Associated With Short Stature and Low IGF-I". [PDF]

J Clin Endocrinol Metab
europepmc   +1 more source