Results 131 to 140 of about 115,801 (264)

Exercise, exerkines, and muscle–brain crosstalk in Parkinson's disease

open access: yesNeuroprotection, EarlyView.
Abstract Parkinson's disease (PD) is a progressive neurodegenerative disorder with motor and non‐motor symptoms, driven by dopaminergic loss and α‐synuclein accumulation. Beyond neurodegeneration, growing evidence highlights skeletal muscle health as a key determinant of prognosis, with sarcopenia and frailty contributing to greater disability, fall ...
Salomón Páez‐García   +7 more
wiley   +1 more source

Current Cell/Organoid and Animal Models for Primary Sclerosing Cholangitis

open access: yesPortal Hypertension &Cirrhosis, EarlyView.
Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease with limited therapeutic options and a marked risk of progression to biliary fibrosis, cirrhosis, and malignancy. Progress in PSC research has been hindered by the lack of models that faithfully recapitulate the complex biliary microenvironment and disease heterogeneity ...
Qigu Yao   +4 more
wiley   +1 more source

Mesenchymal stromal cell therapy for rheumatoid arthritis: Long‐term efficacy, safety, and mechanistic insights

open access: yesRheumatology &Autoimmunity, EarlyView.
Graphical abstract summarizing the multifactorial pathogenesis of rheumatoid arthritis (RA) and the therapeutic potential of mesenchymal stromal cell (MSC) therapy. MSCs provide promising benefits through their immunomodulatory properties, low immunogenicity, ability to promote tissue repair, and multi‐lineage differentiation, presenting a potential ...
Yingjia Chen   +6 more
wiley   +1 more source

Loss-of-Function GHSR Variants Are Associated With Short Stature and Low IGF-I. [PDF]

open access: yesJ Clin Endocrinol Metab
Punt LD   +28 more
europepmc   +1 more source

Fatigue Strength in Additive Toolmaking: A Study of Metal Binder Jetting and Electron Beam Melting for Processing Carbide‐Rich Cold‐Work Tool Steels

open access: yessteel research international, EarlyView.
Focusing on the critical tap hole region of the blast furnace, this work examines binder characteristics, prepares tap hole clay with different formulations, and evaluates their physical properties. The findings confirm the advantages of composite binders and offer a new binder option for tap hole clay.
Frederik Tegeder   +7 more
wiley   +1 more source

In Situ Alloying of H13 Tool Steel With TiC via PBF‐LB/M

open access: yessteel research international, EarlyView.
H13 tool steel is in situ alloyed with titanium carbides (TiC) in amounts up to 30 wt.%. This approach offers the advantage that the carbides melt only partially during processing, preventing excessive carbon enrichment of the steel matrix. The resulting microstructure consists of coarse, undissolved and fine, reprecipitated carbides, leading to grain ...
Oliver Bürgi   +2 more
wiley   +1 more source

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