Results 21 to 30 of about 115,801 (264)

IGF-I, IGF-II and insulin stimulate different gene expression responses through binding to the IGF-I receptor.

Frontiers in Endocrinology, 2013
Insulin and the insulin-like growth factors (IGF)-I and –II are closely related peptides important for regulation of metabolism, growth, differentiation and development. The IGFs exert their main effects through the IGF-I receptor.
Soetkin eVersteyhe, Birgit eKlaproth, Rehannah eBorup, Jane ePalsgaard, Maja eJensen, Steven G. Gray, Steven G. Gray, Pierre eDe Meyts   +7 more
doaj   +1 more source

Relation of IGF-I with subclinical cardiovascular markers including intima-media thickness, left ventricular mass index and NT-proBNP

Endocrine Connections, 2019
Objective: Several studies revealed relations between low or high insulin -like growth factor I (IGF-I) levels and risk of cardiovascular diseases or mortality, whereas the mechanisms be hind these associations are still unknown.
Maximilian Eichner, Henri Wallaschofski, Ulf Schminke, Henry Völzke, Marcus Dörr, Stephan B Felix, Matthias Nauck, Nele Friedrich   +7 more
doaj   +1 more source

Insulin-Like Growth Factor I Receptor (IGF-IR) Ligands and BMI in Squamous Intra-Epithelial Lesion (SIL) of Cervix [PDF]

Journal of Clinical and Diagnostic Research, 2016
Introduction: Cancer cervix is the most common cancer in women in developing countries like India. Several studies have linked insulin-like growth factors-I & II (IGF-I and IGF-II) and IGF binding proteins-3 (IGFBP-3) with pathogenesis of Squamous ...
Praveen Sablania, Swaraj Batra, Alpana Saxena   +2 more
doaj   +1 more source

Effects of IGF-1 on the Three-Dimensional Culture of Ovarian Preantral Follicles and Superovulation Rates in Mice

Biology, 2022
Insulin-like growth factor-1 (IGF-1) plays a crucial role during folliculogenesis, which has been demonstrated by previous research. However, the optimal IGF-1 dosage in the three-dimensional (3D) culture system is unknown. Mouse secondary follicles (140–
Shizhen Dai, Hanxue Zhang, Feng Yang, Wei Shang, Shenming Zeng   +4 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Do IGF-I concentrations better reflect growth hormone (GH) action in children with short stature than the results of GH stimulating tests? Evidence from the simultaneous assessment of thyroid function

Thyroid Research, 2011
Background The diagnosis of growth hormone (GH) deficiency (GHD) in short children seems unquestionable when both GH peak in stimulating tests (GHST) and IGF-I concentration are decreased.
Smyczyńska Joanna, Stawerska Renata, Lewiński Andrzej, Hilczer Maciej   +3 more
doaj   +1 more source

Pre- and Postoperative Circulating IGF-I, IGFBP-3, and IGFBP-7 Levels in Relation to Endocrine Treatment and Breast Cancer Recurrence: A Nested Case-Control Study

Frontiers in Oncology, 2021
Insulin-like growth factor-I (IGF-I) and its binding proteins (BPs) have been associated with breast cancer risk, especially high IGF-I concentrations and the biologically active fraction estimated as the IGF-I/IGFBP-3 molar ratio.
Ann H. Rosendahl, Sofie Björner, Maria Ygland Rödström, Karin Jirström, Signe Borgquist, Signe Borgquist, Christian Ingvar, Michael N. Pollak, Helena Jernström   +8 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Validation of serum IGF-I as a biomarker to monitor the bioactivity of exogenous growth hormone agonists and antagonists in rabbits

Disease Models & Mechanisms, 2014
The development of new growth hormone (GH) agonists and growth hormone antagonists (GHAs) requires animal models for pre-clinical testing. Ideally, the effects of treatment are monitored using the same pharmacodynamic marker that is later used in ...
Maximilian Bielohuby, Sayyed Hamid Zarkesh-Esfahani, Jenny Manolopoulou, Elisa Wirthgen, Katja Walpurgis, Mohaddeseh Toghiany Khorasgani, Zahra Sadat Aghili, Ian Robert Wilkinson, Andreas Hoeflich, Mario Thevis, Richard J. Ross, Martin Bidlingmaier   +11 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source