Results 31 to 40 of about 21,502,425 (295)

Insulin-Like Growth Factor (IGF)-I and -11 and IGFBinding Proteins-l, -2, and -3 in Children and Adolescents with Diabetes Mellitus: Correlation with Metabolic Control and Height Attainment. [PDF]

, 1995
The putative effects of diabetes and metabolic control on circulating levels of insulin-like growth factors (IGFs) and their binding proteins (IGFBPs) remain controversial.
Past, Roswitha, Kessler, Ulrike, Strasser-Vogel, Brigitte, Hoeflich, Andreas, Blum, Werner F., Meiler, Barbara, Kiess, Wieland   +6 more
core   +1 more source

Insulin-Like Growth Factor I Receptor (IGF-IR) Ligands and BMI in Squamous Intra-Epithelial Lesion (SIL) of Cervix [PDF]

Journal of Clinical and Diagnostic Research, 2016
Introduction: Cancer cervix is the most common cancer in women in developing countries like India. Several studies have linked insulin-like growth factors-I & II (IGF-I and IGF-II) and IGF binding proteins-3 (IGFBP-3) with pathogenesis of Squamous ...
Praveen Sablania, Swaraj Batra, Alpana Saxena   +2 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Do IGF-I concentrations better reflect growth hormone (GH) action in children with short stature than the results of GH stimulating tests? Evidence from the simultaneous assessment of thyroid function

Thyroid Research, 2011
Background The diagnosis of growth hormone (GH) deficiency (GHD) in short children seems unquestionable when both GH peak in stimulating tests (GHST) and IGF-I concentration are decreased.
Smyczyńska Joanna, Stawerska Renata, Lewiński Andrzej, Hilczer Maciej   +3 more
doaj   +1 more source

Pre- and Postoperative Circulating IGF-I, IGFBP-3, and IGFBP-7 Levels in Relation to Endocrine Treatment and Breast Cancer Recurrence: A Nested Case-Control Study

Frontiers in Oncology, 2021
Insulin-like growth factor-I (IGF-I) and its binding proteins (BPs) have been associated with breast cancer risk, especially high IGF-I concentrations and the biologically active fraction estimated as the IGF-I/IGFBP-3 molar ratio.
Ann H. Rosendahl, Sofie Björner, Maria Ygland Rödström, Karin Jirström, Signe Borgquist, Signe Borgquist, Christian Ingvar, Michael N. Pollak, Helena Jernström   +8 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

IGF-I signalling in bone growth: Inhibitory actions of dexamethasone and IL-1 beta [PDF]

, 2007
To determine if glucocorticoids and proinflammatory cytokines inhibit bone growth through a common mechanism involving impaired IGF-I ...
Macrae, V.E., Ahmed, S Faisal, Ahmed, S.F., Mushtaq, Talat, Farquharson, C., Farquharson, Colin; id_orcid, Macrae, Vicky E, Mushtaq, T.   +7 more
core   +1 more source

Validation of serum IGF-I as a biomarker to monitor the bioactivity of exogenous growth hormone agonists and antagonists in rabbits

Disease Models & Mechanisms, 2014
The development of new growth hormone (GH) agonists and growth hormone antagonists (GHAs) requires animal models for pre-clinical testing. Ideally, the effects of treatment are monitored using the same pharmacodynamic marker that is later used in ...
Maximilian Bielohuby, Sayyed Hamid Zarkesh-Esfahani, Jenny Manolopoulou, Elisa Wirthgen, Katja Walpurgis, Mohaddeseh Toghiany Khorasgani, Zahra Sadat Aghili, Ian Robert Wilkinson, Andreas Hoeflich, Mario Thevis, Richard J. Ross, Martin Bidlingmaier   +11 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Insulin-like Growth Factor-I Reduces Collagen Production by Hepatic Stellate Cells Through Stimulation of Collagen Degradation System via mTOR-Dependent Signaling Pathway

Biomedicines
Aim: The liver is the major source of circulating insulin-like growth factor (IGF)-I. Serum IGF-I levels are decreased in cirrhotic patients depending on severity.
Takako Nishikawa, Natsuko Ohtomo, Yukiko Inoue, Mami Takahashi, Hitoshi Ikeda, Kazuhiko Koike, Nobutake Yamamichi, Mitsuhiro Fujishiro, Tomoaki Tomiya   +8 more
doaj   +1 more source