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Expression of IGF-II, the IGF-II/Mannose-6-Phosphate Receptor and IGFBP-2 During Rat Embryogenesis
1991It is becoming increasingly apparent that the IGF system (including both IGF-I and IGF-II, at least two IGF receptors, and a family of at least six IGF binding proteins; 1-3) has a fundamental role in the normal progression of prenatal development. The initial observation that IGF-II peptide levels were high in the fetus but decreased post-natally (4 ...
J E, Pintar +5 more
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Hormone Research, 2008
Insulin-like growth factor II (IGF-II) is a polypeptide hormone with structural and functional homology with IGF-I and pro-insulin. It is now thought that IGF-II acts as a growth factor during fetal life and development. In rats, IGF-II levels in the circulation are high in the fetus and decline rapidly after birth.
W, Kiess +3 more
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Insulin-like growth factor II (IGF-II) is a polypeptide hormone with structural and functional homology with IGF-I and pro-insulin. It is now thought that IGF-II acts as a growth factor during fetal life and development. In rats, IGF-II levels in the circulation are high in the fetus and decline rapidly after birth.
W, Kiess +3 more
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Tumor Hypoglycemia Linked to IGF-II
1999Hypoglycemia is a common medical emergency, most often due to untoward effects of insulin administered to patients with diabetes mellitus. It is also a manifestation of many other medical conditions including tumors. The hypoglycemia associated with tumors occurs within a subset of patients who have “spontaneous” or fasting hypoglycemia, i.e., the fall
Christian A. Koch +2 more
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The IGF-II-deficient placenta: aspects of its function
Trends in Endocrinology & Metabolism, 2002Abstract Gene ablation in mice has provided compelling evidence of the role that insulin-like growth factors (IGFs) and their receptors play in fetal and placental development. The recent deletion of the P0 transcript encoding IGF-II specifically within the labyrinthine trophoblast, resulted in placental and fetal growth restriction.
Timothy R H, Regnault +2 more
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Effects of IGF-II in a New End-To-Side Model
Journal of Reconstructive Microsurgery, 1999Insulin-like growth factor-II (IGF-II) has been shown to increase the rate of axon regeneration in a number of models involving the rat sciatic nerve. This project studied the effects of IGF-II on an end-to-side nerve repair. In this study, the musculocutaneous nerve of a Sprague-Dawley rat was transected and coapted by end-to-side neurorrhaphy to the ...
J, Caplan, D A, Tiangco, J K, Terzis
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Preparation of a Photoaffinity Probe for the Man6P/IGF-II Receptor
Biological Chemistry Hoppe-Seyler, 1993A photoaffinity probe, 2-(4-phosphopentamanniminophenyl)ethyl-(4-azido) salicylamide, was prepared for photolabelling of the mannose 6-phosphate/insulin-like growth factor II receptor. The probe was synthesized from phosphopentamannan and 2-(4-aminophenyl)ethylamine followed by coupling with photosensitive 4-azidosalicylic acid. The 125I-labelled probe
T, Miyagishima +4 more
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Parental Imprinting of the Genes for IGF-II and Its Receptor
1994One of the basic tenets of Mendelian genetics is that autosomal traits are equivalently transmitted from each of the two parents. In recent years the molecular corollary of this has also been demonstrated for the majority of the genes studied: Both copies of each autosomal gene are equivalently expressed at the mRNA level, regardless of the parent from
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Characterization of IGF-II and IGF-II Precursors in Human Plasma.
2010AG Marks, JQ Purnell, CT Roberts
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