Syndecan-2 is a novel target of insulin-like growth factor binding protein-3 and is over-expressed in fibrosis. [PDF]
PLoS ONE, 2012 Extracellular matrix deposition and tissue scarring characterize the process of fibrosis. Transforming growth factor beta (TGFβ) and Insulin-like growth factor binding protein-3 (IGFBP-3) have been implicated in the pathogenesis of fibrosis in various ...
Ximena D Ruiz +6 more
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Opposing Roles of IGFBP-3 and Heparanase in Regulating A549 Lung Cancer Cell Survival [PDF]
Cells, 2022 In this study, we examined the roles of heparanase and IGFBP-3 in regulating A549 and H1299 non-small-cell lung cancer (NSCLC) survival. We found that H1299 cells, known to be p53-null with no expression of IGFBP-3, had higher heparanase levels and ...
Hind Al Khashali +9 more
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IGFBP-3 inhibits cytokine-induced insulin resistance and early manifestations of atherosclerosis. [PDF]
PLoS ONE, 2013 Metabolic syndrome is associated with visceral obesity, insulin resistance and an increased risk of cardiovascular diseases. Visceral fat tissue primarily consists of adipocytes that secrete cytokines leading to a state of systemic inflammation in obese ...
Lathika Mohanraj +9 more
doaj +5 more sources
Roles of IGFBP-3 in cell migration and growth in an endophytic tongue squamous cell carcinoma cell line [PDF]
Scientific Reports, 2022 Insulin-like growth factor binding protein-3 (IGFBP-3) is a member of the IGFBP family that has high affinity for IGFs and functions as either an oncogene or tumor suppressor in various types of cancer.
Esther Feng Ying Ng +3 more
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Circulating IGFBP-3 and Interleukin 6 as Predictors of Osteoporosis in Postmenopausal Women: A Cross-Sectional Study [PDF]
Mediators of Inflammation, 2023 Objective. To explore the relationship between circulating IGFBP-3, IL-6, and bone mineral density and the potential diagnostic role of circulating IGFBP-3 and IL-6 in postmenopausal women with osteoporosis. Methods.
Xiu Shi +4 more
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Biochemical determinants of the IGFBP‐3–hyaluronan interaction [PDF]
FEBS Open Bio, 2020 IGFBP‐3, the most abundant IGFBP and the main carrier of insulin‐like growth factor I (IGF‐I) in the circulation, can bind IGF‐1 with high affinity, which attenuates IGF/IGF‐IR interactions, thereby resulting in antiproliferative effects.
Sadaf Dorandish +7 more
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IGFBP-3/IGFBP-3 Receptor System as an Anti-Tumor and Anti-Metastatic Signaling in Cancer [PDF]
Cells, 2020 Insulin-like growth factor binding protein-3 (IGFBP-3) is a p53 tumor suppressor-regulated protein and a major carrier for IGFs in circulation. Among six high-affinity IGFBPs, which are IGFBP-1 through 6, IGFBP-3 is the most extensively investigated ...
Qing Cai, Mikhail Dozmorov, Youngman Oh
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Role of Insulin-Like Growth Factor Binding Protein-3 in 1, 25-Dihydroxyvitamin-D3-Induced Breast Cancer Cell Apoptosis [PDF]
International Journal of Cell Biology, 2013 Insulin-like growth factor I (IGF-I) is implicated in breast cancer development and 1, 25-dihydroxyvitamin D3 (1, 25-D3) has been shown to attenuate prosurvival effects of IGF-I on breast cancer cells.
C. Brosseau, G. Pirianov, K. W. Colston
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Association Study of IGF-1 rs35767 and rs6214 Gene Polymorphisms with Cancer Susceptibility and Circulating Levels of IGF-1, IGFBP-2, and IGFBP-3 in Colorectal Cancer Patients [PDF]
Biomedicines, 2023 Early detection of colorectal cancer (CRC) increases the 5-year survival rate by 90%; therefore, non-invasive biomarkers such as measurable circulating proteins for early detection and prognosis are crucial.
Maryam H. Alrashid +4 more
doaj +2 more sources
Molecular evidence of IGFBP-3 dependent and independent VD3 action and its nonlinear response on IGFBP-3 induction in prostate cancer cells [PDF]
BMC Cancer, 2020 Background Clinical trials have been conducted to clarify the beneficial effects of VD3 (1α,25-dihydroxy vitamin D3, also known as calcitriol) treatment in prostate cancer.
Ko Igarashi +7 more
doaj +2 more sources