IGFBP-3/IGFBP-3 Receptor System as an Anti-Tumor and Anti-Metastatic Signaling in Cancer [PDF]
Cells, 2020 Insulin-like growth factor binding protein-3 (IGFBP-3) is a p53 tumor suppressor-regulated protein and a major carrier for IGFs in circulation. Among six high-affinity IGFBPs, which are IGFBP-1 through 6, IGFBP-3 is the most extensively investigated ...
Mikhail G Dozmorov, Youngman Oh
exaly +8 more sources
Biochemical determinants of the IGFBP‐3–hyaluronan interaction [PDF]
FEBS Open Bio, 2020 IGFBP‐3, the most abundant IGFBP and the main carrier of insulin‐like growth factor I (IGF‐I) in the circulation, can bind IGF‐1 with high affinity, which attenuates IGF/IGF‐IR interactions, thereby resulting in antiproliferative effects.
Sadaf Dorandish +7 more
doaj +6 more sources
Impact of IGFBP-3 A-202C genetic variant on breast cancer susceptibility and serum biomarkers (IGFBP-3 and IGF-1) in Palestinian women. [PDF]
PLoS ONEBreast cancer is the most common diagnosed cancer and the leading cause of cancer-related deaths among women globally. This study examined the impact of insulin-like growth factor binding protein-3 (IGFBP-3) A-202C polymorphism (rs2854744) on breast ...
Heba Mohammed Arafat +7 more
doaj +5 more sources
Opposing Roles of IGFBP-3 and Heparanase in Regulating A549 Lung Cancer Cell Survival [PDF]
Cells, 2022 In this study, we examined the roles of heparanase and IGFBP-3 in regulating A549 and H1299 non-small-cell lung cancer (NSCLC) survival. We found that H1299 cells, known to be p53-null with no expression of IGFBP-3, had higher heparanase levels and ...
Hind Al Khashali +9 more
doaj +2 more sources
Circulating IGFBP-3 and Interleukin 6 as Predictors of Osteoporosis in Postmenopausal Women: A Cross-Sectional Study [PDF]
Mediators of Inflammation, 2023 Objective. To explore the relationship between circulating IGFBP-3, IL-6, and bone mineral density and the potential diagnostic role of circulating IGFBP-3 and IL-6 in postmenopausal women with osteoporosis. Methods.
Xiu Shi +4 more
doaj +2 more sources
Roles of IGFBP-3 in cell migration and growth in an endophytic tongue squamous cell carcinoma cell line [PDF]
Scientific Reports, 2022 Insulin-like growth factor binding protein-3 (IGFBP-3) is a member of the IGFBP family that has high affinity for IGFs and functions as either an oncogene or tumor suppressor in various types of cancer.
Esther Feng Ying Ng +3 more
doaj +2 more sources
Molecular evidence of IGFBP-3 dependent and independent VD3 action and its nonlinear response on IGFBP-3 induction in prostate cancer cells [PDF]
BMC Cancer, 2020 Background Clinical trials have been conducted to clarify the beneficial effects of VD3 (1α,25-dihydroxy vitamin D3, also known as calcitriol) treatment in prostate cancer.
Ko Igarashi +7 more
doaj +2 more sources
Association Study of IGF-1 rs35767 and rs6214 Gene Polymorphisms with Cancer Susceptibility and Circulating Levels of IGF-1, IGFBP-2, and IGFBP-3 in Colorectal Cancer Patients [PDF]
Biomedicines, 2023 Early detection of colorectal cancer (CRC) increases the 5-year survival rate by 90%; therefore, non-invasive biomarkers such as measurable circulating proteins for early detection and prognosis are crucial.
Maryam H. Alrashid +4 more
doaj +2 more sources
Role of insulin-like growth factor binding protein-3 in glucose and lipid metabolism [PDF]
Annals of Pediatric Endocrinology & Metabolism, 2013 Insulin-like growth factor binding protein (IGFBP)-3 has roles in modulating the effect of IGFs by binding to IGFs and inhibiting cell proliferation in an IGF-independent manner.
Ho-Seong Kim
doaj +1 more source
Role of IGF-binding protein 3 in the resistance of EGFR mutant lung cancer cells to EGFR-tyrosine kinase inhibitors. [PDF]
PLoS ONE, 2013 Most patients treated with EGFR-tyrosine kinase inhibitors (EGFR-TKIs) eventually develop acquired resistance. Loss of expression of insulin-like growth factor (IGF)-binding protein-3 (IGFBP-3) has been suggested as a possible mechanism of resistance to ...
Yun Jung Choi +7 more
doaj +1 more source