Results 201 to 210 of about 45,932 (257)

IGFBPs and Breast Cancer

Breast Disease, 2003
The IGFBP family comprises 6 proteins with high affinity for the IGFs, there are also several much lower affinity IGFBP-related proteins. Their production in the breast is controlled by hormones, other local regulators and in tumours relates to the estrogen receptor status.
Claire M, Perks, Jeff M P, Holly
openaire   +2 more sources

IGFBP-4 and PAPP-A in normal physiology and disease.

Growth Hormone & IGF Research, 2018
Insulin-like growth factor (IGF) binding protein-4 (IGFBP-4) is a modulator of the IGF system, exerting both inhibitory and stimulatory effects on IGF-induced cellular growth.
R. Hjortebjerg
semanticscholar   +1 more source

Phylogenetic analysis of the insulin-like growth factor binding protein (IGFBP) and IGFBP-related protein gene families

General and Comparative Endocrinology, 2008
Insulin-like growth factor (IGF) activity is regulated by six high affinity binding proteins (IGFBPs) and possibly by some of the nine IGFBP-related proteins (IGFBP-rPs).
Eric Howard Roalson, Buel Rodgers
exaly   +2 more sources

Genetic ablation of IGFBP-2 suggests functional redundancy in the IGFBP family

Progress in Growth Factor Research, 1995
Gene targeting allows mutations to be introduced selectively into any mouse locus of interest. This approach has already been used to demonstrate that insulin-like growth factor (IGF) peptides and receptors are required in vivo for normal prenatal growth. One of the IGFBP genes, IGFBP-2, has also been disrupted using gene targeting, and homozgyous null
J E, Pintar, A, Schuller, J A, Cerro, M, Czick, A, Grewal, B, Green   +5 more
openaire   +2 more sources

IGFBPs down under

Trends in Endocrinology & Metabolism, 2001
Abstract The Fourth International Workshop on insulin-like growth factor binding proteins (IGFBPs) was held on 26–29 October 2000 in Terrigal, NSW, Australia.
openaire   +2 more sources

IGFs and IGFBPs in GH Insensitivity

2005
IGF-I, IGFBP-3 and ALS are GH-dependent peptides and their production is disturbed in states of GH insensitivity. This chapter explores the relative degrees of IGF-I, IGFBP-3 and ALS deficiency across the spectrum of GH insensitivity. In classical GH insensitivity syndrome (GHIS), known as Laron syndrome, due to GH receptor (GHR) deficiency, serum IGF ...
SAVAGE MO, BLAIR JC, JORGE AJ, STREET, Maria Elisabeth, RANKE MB, CAMACHO HUBNER C.   +5 more
openaire   +3 more sources

Molecular cloning of IGFBP-5 from SCLC cell lines and expression of IGFBP-4, IGFBP-5 and IGFBP-6 in lung cancer cell lines and primary tumours

European Journal of Cancer, 1993
We showed recently that insulin-like growth factor binding protein (IGFBP)-1, -2 and -3 are differentially expressed in lung cancer and permanent lung cancer cell lines. Elevated levels of IGF binding capacity in serum of lung cancer patients were also reported.
B R, Wegmann, H J, Schöneberger, P E, Kiefer, G, Jaques, D, Brandscheid, K, Havemann   +5 more
openaire   +2 more sources

IGFBP-3 and IGFBP-5 associate with the cell binding domain (CBD) of fibronectin

Biochemical and Biophysical Research Communications, 2009
We have used Surface Plasmon Resonance (SPR) - based biosensor technology to investigate the interaction of the six high affinity insulin-like growth factor binding proteins (IGFBP 1-6) with the cell binding domain (CBD) of fibronectin. Using a biotinylated derivative of the ninth and tenth TypeIII domains of FN ((9-10)FNIII), we show that IGFBP-3 and -
Beattie, James, Kreiner, M., Allan, G.J., Flint, D.J., Domingues, Diana, van der Walle, Christopher F.   +5 more
openaire   +4 more sources

The Stanniocalcin-PAPP-A-IGFBP-IGF Axis

The Journal of Clinical Endocrinology & Metabolism, 2023
Abstract The pappalysin metalloproteinases, PAPP-A and PAPP-A2, have emerged as highly specific proteolytic enzymes involved in the regulation of insulin-like growth factor (IGF) signaling. The only known pappalysin substrates are a subset of the IGF binding proteins (IGFBPs), which bind IGF-I or IGF-II with high affinity to antagonize ...
Claus Oxvig, Cheryl A Conover
openaire   +2 more sources

IGFBP-1 protease activity and IGFBP-1 fragments in a patient with multiple myeloma

Growth Hormone & IGF Research, 2009
Cleavage of IGFBPs by proteases results in IGFBP fragments that have altered IGF-binding affinity, and IGF-independent roles. We have previously purified a specific IGFBP-1 protease activity from the urine of an individual with multiple myeloma and dermatitis.
Katrin, Brandt, Jing, Wang, Kerstin, Lundell, Marie, Ståhlberg, Henrik von, Horn, Ewa, Ehrenborg, Kerstin, Hall, Hans, Jörnvall, Moira, Lewitt   +8 more
openaire   +2 more sources