Results 261 to 270 of about 1,581,690 (305)
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The Lancet Rheumatology, 2023
BACKGROUND Obexelimab is a bifunctional, non-cytolytic, humanised monoclonal antibody that binds CD19 and Fc gamma receptor IIb to inhibit B cells, plasmablasts, and CD19-expressing plasma cells.
C. Perugino +15 more
semanticscholar +1 more source
BACKGROUND Obexelimab is a bifunctional, non-cytolytic, humanised monoclonal antibody that binds CD19 and Fc gamma receptor IIb to inhibit B cells, plasmablasts, and CD19-expressing plasma cells.
C. Perugino +15 more
semanticscholar +1 more source
Development of an algorithm for IgG4-related disease management.
Autoimmunity Reviews, 2023OBJECTIVES IgG4-related disease (IgG4-RD) is a rare fibro-inflammatory condition affecting multiple organs lacking standardized management. In this article, we review the evidence available to provide European expert-based statements on the management of
O. Orozco-Gálvez +9 more
semanticscholar +1 more source
Annals of the Rheumatic Diseases, 2023
Objectives The aim of this study is to profile the transcriptional landscapes of affected tissues and peripheral blood mononuclear cells (PBMCs) at the single-cell level in IgG4-related disease (IgG4-RD).
Yanmei Li +16 more
semanticscholar +1 more source
Objectives The aim of this study is to profile the transcriptional landscapes of affected tissues and peripheral blood mononuclear cells (PBMCs) at the single-cell level in IgG4-related disease (IgG4-RD).
Yanmei Li +16 more
semanticscholar +1 more source
IgG4-related disease: advances in pathophysiology and treatment
Expert Review of Clinical Immunology, 2023Introduction IgG4-related disease (IgG4-RD) is a rare fibro-inflammatory disease affecting multiple organs. In recent years basic and translational research has unveiled the role of different cellular subtypes and cytokines in inducing and perpetuating ...
F. Peyronel +4 more
semanticscholar +1 more source
IgG4-related disease: a clinical perspective.
Rheumatology, 2020IgG4-related disease (IgG4-RD) is a recently recognized fibro-inflammatory disorder that can affect almost any organ. Common presentations include major salivary and lacrimal gland enlargement, orbital disease, autoimmune pancreatitis, retroperitoneal ...
F. Maritati, F. Peyronel, A. Vaglio
semanticscholar +1 more source
Clinical Journal of the American Society of Nephrology, 2023
The term “IgG4-related disease” was recently coined to identify a rare systemic disorder hallmarked by fibro-inflammatory, tumor-like masses possibly affecting almost any organ. Pathologic tissues are characterized by dense, polyclonal, lymphoplasmacytic infiltrates, rich in IgG4-positive plasma cells on a background of fibrosis, which often has a ...
Francesco Peyronel, Augusto Vaglio
openaire +2 more sources
The term “IgG4-related disease” was recently coined to identify a rare systemic disorder hallmarked by fibro-inflammatory, tumor-like masses possibly affecting almost any organ. Pathologic tissues are characterized by dense, polyclonal, lymphoplasmacytic infiltrates, rich in IgG4-positive plasma cells on a background of fibrosis, which often has a ...
Francesco Peyronel, Augusto Vaglio
openaire +2 more sources
Best Practice & Research Clinical Rheumatology, 2012
Immunoglobulin G4 (IgG4)-related disease (IgG4-RD) is a fascinating condition recognised as a systemic disease in 2003 [1,2]. The first link between autoimmunity affecting the pancreas, elevated serum IgG4 concentrations and large numbers of IgG4-positive plasma cells in pancreatic tissue was described only 2 years earlier [3].
Monica, Guma, Gary S, Firestein
openaire +2 more sources
Immunoglobulin G4 (IgG4)-related disease (IgG4-RD) is a fascinating condition recognised as a systemic disease in 2003 [1,2]. The first link between autoimmunity affecting the pancreas, elevated serum IgG4 concentrations and large numbers of IgG4-positive plasma cells in pancreatic tissue was described only 2 years earlier [3].
Monica, Guma, Gary S, Firestein
openaire +2 more sources
Modern Rheumatology, 2022
IgG4-related disease (IgG4-RD) is a chronic fibro-inflammatory disease that may cause dysfunction in various organs. World-wide multidisciplinary experts attending the Fourth International Symposium on IgG4-Related Disease in Japan in 2021 discussed ...
H. Yoshifuji, H. Umehara
semanticscholar +1 more source
IgG4-related disease (IgG4-RD) is a chronic fibro-inflammatory disease that may cause dysfunction in various organs. World-wide multidisciplinary experts attending the Fourth International Symposium on IgG4-Related Disease in Japan in 2021 discussed ...
H. Yoshifuji, H. Umehara
semanticscholar +1 more source
Archivos de la Sociedad Española de Oftalmología (English Edition), 2018
The case is presented of a 64-year-old woman with bilateral palpebral swelling and dacryoadenitis, exophthalmos, and a history of chronic rhinitis and asthma. An increase in serum IgG4 was observed, and an incisional biopsy of lacrimal glands was performed, which showed fibrosis and a lymphoplasmacytic infiltrate with IgG4 producing cells.Orbital ...
J, Flores Balverdi +5 more
openaire +2 more sources
The case is presented of a 64-year-old woman with bilateral palpebral swelling and dacryoadenitis, exophthalmos, and a history of chronic rhinitis and asthma. An increase in serum IgG4 was observed, and an incisional biopsy of lacrimal glands was performed, which showed fibrosis and a lymphoplasmacytic infiltrate with IgG4 producing cells.Orbital ...
J, Flores Balverdi +5 more
openaire +2 more sources
British Journal of Dermatology, 2014
IgG4-related disease (IgG4-RD) is a recently established clinical entity characterized by high levels of circulating IgG4, and tissue infiltration of IgG4(+) plasma cells. IgG4-RD exhibits a distinctive fibroinflammatory change involving multiple organs, such as the pancreas and salivary and lacrimal glands. The skin lesions of IgG4-RD have been poorly
Y, Tokura +7 more
openaire +2 more sources
IgG4-related disease (IgG4-RD) is a recently established clinical entity characterized by high levels of circulating IgG4, and tissue infiltration of IgG4(+) plasma cells. IgG4-RD exhibits a distinctive fibroinflammatory change involving multiple organs, such as the pancreas and salivary and lacrimal glands. The skin lesions of IgG4-RD have been poorly
Y, Tokura +7 more
openaire +2 more sources