Results 1 to 10 of about 1,474,310 (169)
Molecular Therapy: Nucleic Acids, 2022 Human B lymphocytes are attractive targets for immunotherapies in autoantibody-mediated diseases. Gene editing technologies could provide a powerful tool to determine gene regulatory networks regulating B cell differentiation into plasma cells, and ...
Tuan Anh Le +8 more
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Data-Driven Mathematical Model of Apoptosis Regulation in Memory Plasma Cells
Cells, 2022 Memory plasma cells constitutively produce copious amounts of antibodies, imposing a critical risk factor for autoimmune disease. We previously found that plasma cell survival requires secreted factors such as APRIL and direct contact to stromal cells ...
Philipp Burt +6 more
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Diagnosis of AL amyloidosis on bone marrow aspirate smears - A Case Report
Apollo Medicine, 2022 Introduction: An amyloidosis is a group of diseases associated with the deposition of abnormal protein fibrils in the tissues. Primary amyloidosis (AL) type is the most common form of systemic amyloidosis encountered in clinical settings resulting from ...
Supraja Sundaram +3 more
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IgG4 Licks base of skull, wastes tongue: An unusual presentation
Indian Journal of Rheumatology, 2021 IgG4 Related disease (IgG4 RD) is a rapidly evolving clinical entity, involving multiple organs, manifesting clinically as tumefactive lesions, histopathologically characterized by an IgG4 predominant, dense lymphoplasmacytic tissue infiltrate.
Shekhar Dorle +6 more
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Frontiers in Cell and Developmental Biology, 2021 Background: The role of tumor-associated B cells in human cancer is only starting to emerge. B cells typically undergo a series of developmental changes in phenotype and function, however, data on the composition of the B cell population in human ...
Minyi Chen +8 more
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Longevity of vaccine protection: Immunological mechanism, assessment methods, and improving strategy
View, 2022 Vaccination represents one of the most important achievements in modern medicine. During the era of COVID‐19 pandemic, the successful vaccination for SARS‐COV‐2 is the major hope to bring the society back to normal.
Zhian Chen, Xin Gao, Di Yu
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Cerebellar infarction as the initial presentation of IgG4‐related disease
Clinical Case Reports, 2022 Although IgG4‐RD has CNS manifestations, cerebellar involvement has only been reported in three cases. Our patient presented with cerebellar symptoms, several cerebellar infarcts were evident on the brain MRI, and CT abdomen revealed retroperitoneal ...
Branden Ireifej +7 more
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Heterogeneity of antibody-secreting cells infiltrating autoimmune tissues
Frontiers in Immunology, 2023 The humoral response is frequently dysfunctioning in autoimmunity with a frequent rise in total serum immunoglobulins, among which are found autoantibodies that may be pathogenic by themselves and/or propagate the inflammatory reaction.
Diane Giovannini +16 more
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Blood, 1946 Abstract A case of plasma cell leukemia is reported, together with a review of the literature, including a summary of the signs, symptoms, and laboratory findings usually present. The relationship of this leukemic state to ordinary plasmacytoma, a tumor of white cell origin, is discussed.
W T, MOSS, L V, ACKERMAN
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