Results 31 to 40 of about 1,474,310 (169)
Farnesyltransferase-inhibitors exert in vitro immunosuppressive capacity by inhibiting human B-cells
Frontiers in Transplantation, 2023 ObjectivesFarnesyltransferase inhibitors (FTI), which inhibit the prenylation of Ras GTPases, were developed as anti-cancer drugs. As additional target proteins for prenylation were identified in the past, it is likely that FTI have potential value for ...
Shilei Xu +10 more
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Vaccines, 2020 Rabies, caused by the rabies virus (RABV), remains a serious threat to public health in most countries. Development of a single-dose and efficacious rabies vaccine is the most important method to restrict rabies virus transmission.
Yingying Li +5 more
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B cell intrinsic and extrinsic factors impacting memory recall responses to SRBC challenge
Frontiers in Immunology, 2022 MBCs (MBCs) generated in T-dependent immune responses can persist for a lifetime and rapidly react upon secondary antigen exposure to differentiate into plasma cells (PCs) and/or to improve the affinity of their BCR through new rounds of hypermutation in
Viviana Valeri +9 more
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Factors Regulating Immunoglobulin Production by Normal and Disease-Associated Plasma Cells
Biomolecules, 2015 Immunoglobulins are molecules produced by activated B cells and plasma cells in response to exposure to antigens. Upon antigen exposure, these molecules are secreted allowing the immune system to recognize and effectively respond to a myriad of pathogens.
David A. Jackson, Sherine F. Elsawa
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Role of IgM Memory B Cells and Spleen Function in COVID-19
Frontiers in Immunology, 2022 IgM memory B cells, are a peculiar subset of memory B cells, which probably originates in the spleen and outside germinal centers and provide a rapid line of defence against mucosal infections.
Carlo Maria Rossi +3 more
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Strong Clonal Relatedness between Serum and Gut IgA despite Different Plasma Cell Origins
Cell Reports, 2017 Mucosal antigens induce generation of lamina propria plasma cells (PCs) that secrete dimeric immunoglobulin A (IgA) destined for transport across the epithelium. In addition, blood contains monomeric IgA.
Rasmus Iversen +8 more
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Myelomatous Pleural Effusion: A Rare Case Report and Literature Review
Case Reports in Oncology, 2022 Multiple myeloma (MM) is typically characterized by the neoplastic proliferation of plasma cells producing a monoclonal immunoglobulin. Pleural effusion in MM is uncommon and usually caused by heart failure, pulmonary embolus, and nephrotic syndrome ...
Zakaria Maat +4 more
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OncoImmunology, 2019 Tumor-infiltrating lymphocytes (TILs) are correlated to prognosis of several kinds of cancer. Most studies focused on T cells, while the role of tumor-associated B cells (TABs) has only recently gained more attention.
Hans A. Schlößer +18 more
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Frontiers in Immunology, 2021 The bone marrow is a complex ecosystem in which hematopoietic and non-hematopoietic cells reside. In this review, we discuss the bone marrow niches in mice that facilitate the survival, maintenance, and differentiation of cells of hematopoietic origin ...
Amélie Bonaud +7 more
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