Results 51 to 60 of about 10,698,899 (242)

IgG4-to-IgG Ratio and Orbital Involvement Predict Clinical Response to B Cell Depletion in IgG4-Related Disease. [PDF]

ACR Open Rheumatol
Objective IgG4‐related disease (RD) demonstrates ethnic variations in phenotype, but data from diverse US populations are limited. We characterized ethnic differences in organ involvement and evaluated predictors of treatment response in a multiethnic cohort.
Cho YM, Quinteros A, Khattar P, Edelman MC, El Khoury L, Marder G.   +5 more
europepmc   +2 more sources

Distinct metabolic biomarkers to distinguish IgG4-related disease from Sjogren’s syndrome and pancreatic cancer and predict disease prognosis

BMC Medicine, 2022
Background The pathogenesis of immunoglobulin G4-related disease (IgG4-RD) remains unclear. IgG4-RD often mimics other diseases, including pancreatic cancer (PC) and Sjogren’s syndrome (SS), which may easily lead to misdiagnosis. This study was performed
Songxin Yan, Yu Peng, Ziyan Wu, Linlin Cheng, Haolong Li, Honglin Xu, Yuan Huang, Wen Zhang, Yongzhe Li   +8 more
doaj   +1 more source

Complemental Diagnosis of IgG4-Related Pancreaticobiliary Diseases by Multiple Hypoechoic Lesions in the Submandibular Glands

, 2022
The diagnosis of autoimmune pancreatitis (AIP) and immunoglobulin G4-related sclerosing cholangitis (IgG4-SC) may require a somewhat invasive pathological examination and steroid responsiveness.
Sato, Tadashi, Yoshimitsu Fukasawa, Tatsuya Yamaguchi, Kadokura, Makoto, Enomoto, Nobuyuki, Dai Yoshimura, Shinya Maekawa, Makoto Kadokura, Takahashi, Ei, Tadashi Sato, Naruki Shimamura, Kawakami, Satoshi, Hayakawa, Hiroshi, Taisuke Inoue, Imagawa, Naoto, Yoshimura, Dai, Harai, Shota, Natsuhiko Kuratomi, Hiroshi Hayakawa, Fukasawa, Mitsuharu, Kuratomi, Natsuhiko, Maekawa, Shinya, Hirose, Sumio, Inoue, Taisuke, Shota Harai, Mitsuharu Fukasawa, Sumio Hirose, Nobuyuki Enomoto, Satoshi Kawakami, Shindo, Hiroko, Shimamura, Naruki, Fukasawa, Yoshimitsu, Hiroko Shindo, Naoto Imagawa, Takano, Shinichi, Ei Takahashi, Shinichi Takano, Hasegawa, Hiroyuki, Yamaguchi, Tatsuya, Hiroyuki Hasegawa   +39 more
core   +1 more source

Abatacept Reduces CD319+ (SLAMF7) Cytotoxic T Cells and Cytokine Production in Systemic Sclerosis

Arthritis &Rheumatology, EarlyView.
Objective Systemic sclerosis (SSc) is characterized by immune dysregulation and fibrosis. We investigated whether abatacept modulates CD319/SLAMF7‐expressing cytotoxic T cells implicated in diffuse cutaneous SSc. Methods In this ancillary ASSET trial analysis, peripheral blood mononuclear cells from 67 participants were analyzed at baseline and months ...
Mikel Gurrea‐Rubio, Laura A. Cooney, Kohei Maeda, Phillip L. Campbell, Qi Wu, Camila I. Amarista, Alexander Stinson, Ray Ohara, Yang Mao‐Draayer, Michael L. Whitfield, Shiv Pillai, Poulami Dey, Johann E. Gudjonsson, Pei‐Suen Tsou, Dinesh Khanna, David A. Fox   +15 more
wiley   +1 more source

Symptomatic IgG4-Related Prostatitis Simultaneously Diagnosed with Aggressive Prostate Cancer

Case Reports in Urology, 2020
IgG4-related disease is a systemic fibroinflammatory disorder that occasionally affects the prostate. It is usually considered that patients with IgG4-related disease are at high risk of developing malignancies.
Taisuke Ezaki, Seiya Akatsuka, Tansei Sanjo, Takeshi Masuda   +3 more
doaj   +1 more source

IgG4-related disease in patients with newly diagnosed idiopathic retroperitoneal fibrosis: a population-based Danish study

, 2019
Objectives: IgG4-related disease (IgG4-RD) may present as ‘idiopathic’ retroperitoneal fibrosis (IRPF). We aimed to determine the occurrence of IgG4-retroperitoneal fibrosis (IgG4-RPF) in a nationwide study on patients with newly diagnosed IRPF, and to ...
N Lomborg (6531722), CS Bode (6531728), M Jakobsen (6531725), P Junker (3104853)   +3 more
core   +1 more source

Диагностическая ценность IgG4 сыворотки крови при IgG4-связанном заболевании: так ли она велика? [PDF]

, 2019
IgG4-related disease (IgG4-RD) is a systemic immune mediated condition that is characterized by the formation of tumor-like fibroinflamma-tory foci in different organs and by the elevation of serum and tissue IgG4 levels in the majority of patients.
Е. В. Сокол, E. V. Sokol, A. V. Torgashina, M. V. Cherkasova, М. В. Черкасова, А. В. Торгашина   +5 more
core   +1 more source

Congruent microbiome signatures in fibrosis-prone autoimmune diseases : IgG4-related disease and systemic sclerosis

, 2021
Funding Information: SP and RJX were supported by National Institute of Allergy and Infectious Diseases (NIAID) grant U19 AI110495. JHS, CAP, ZSW, and ADF were supported by NIAID grant UM1 AI144295.
Chung, Daniel C., Khanna, Dinesh, Lähdesmäki, Harri, Somani, Juhi, Plichta, Damian R., Xavier, Ramnik J., Wallace, Zachary S., Pichaud, Matthieu, Stone, John H., Perugino, Cory A., Pillai, Shiv, Fernandes, Ana D., Vlamakis, Hera   +12 more
core   +1 more source

Adverse immunostimulation in early phase clinical trials: Key findings and recommendations based on the investigator's clinical experience

British Journal of Clinical Pharmacology, EarlyView.
Problem setting The emergence of therapeutic proteins has coincided with an increase of acute adverse immunostimulation (AIS). AIS has occured in clinical trials despite compliance with regulatory guidelines on preclinical evaluation and its incidence is anticipated to increase even further.
Juliette A. van den Noort, Marella C. E. van Ruissen, Lisanne C. A. Smidt, Naomi B. Klarenbeek, Philip H. K. Kremer, Manon A. A. Jansen, Jacobus Burggraaf, Joop M. A. van Gerven, Matthijs Moerland   +8 more
wiley   +1 more source

IGG4-related diseases in endocrinology

Problems of Endocrinology, 2020
Immunoglobulin-G4-related disease (IgG4-RD) is a chronic immunomediated pathology of different organs of local or systemic nature, which has been established as a separate clinical entity in the early 2000s and is characterized by storiform fibroid inflammation of the affected tissues, their increase, and elevated serum immunoglobulin-G4 (IgG4) levels.
Pavel O. Rumyantsev, Ivan G. Kozlov, Evgenia A. Kolpakova, Olga S. Chukhacheva, Sergey V. Korenev, Andrei G. Goncharov, Elena U. Ulanova   +6 more
openaire   +3 more sources