Results 101 to 110 of about 46,091 (305)

The Evolution of Sesame Seed Allergy Over Time

Allergy, EarlyView.
This study analyzes the natural history of sesame over time and the changes in biomarkers between sesame allergic and sesame sensitised but tolerant children. The period prevalence of sesame allergy increased from 0.5% between 12 and 36 m to 1.5% between 7 and 12 y children in the EAT‐On study with 10 children developing new sesame allergy. Sesame‐sIgE
Ru‐Xin Foong, George Du Toit, Henry T. Bahnson, Ronald van Ree, Suzana Radulovic, Serge A. Versteeg, Joanna Craven, Matthew Kwok, Zainab Jama, Helen A. Brough, Kirsty Logan, Michael R. Perkin, Carsten Flohr, Alexandra F. Santos, Gideon Lack   +14 more
wiley   +1 more source

Drug cross-reactivity between methimazole and propylthiouracil causing recurrent pancreatitis in thyroid storm

Endocrinology, Diabetes & Metabolism Case Reports
Drug-induced pancreatitis represents 1.1% of acute pancreatitis cases. To date, eight cases of antithyroid drug (ATD)-induced pancreatitis have been reported, including seven associated with methimazole (MMI) and one with carbimazole; however, no cases ...
Yuriko Yamazaki, Junichiro Adachi, Yurika Ishihara, Yuto Moriwaki, Wataru Muraoka, Sho Miyashita, Yuki Okuno, Takashi Omura, Yoshihiko Izumida   +8 more
doaj   +1 more source

Antibody structure and engineering considerations for the design and function of Antibody Drug Conjugates (ADCs)

OncoImmunology, 2018
Antibody-drug conjugates (ADCs) are emerging as effective tools in cancer therapy, combining the antibody's exquisite specificity for the target antigen-expressing cancer cell together with the cytotoxic potency of the payload.
Ricarda M. Hoffmann, Ben G. T. Coumbe, Debra H. Josephs, Silvia Mele, Kristina M. Ilieva, Anthony Cheung, Andrew N. Tutt, James F. Spicer, David E. Thurston, Silvia Crescioli, Sophia N. Karagiannis   +10 more
doaj   +1 more source

IgG4-related disease: current challenges and future prospects

, 2016
David Lang,1 Jochen Zwerina,2 Herwig Pieringer1,3 1Second Department of Internal Medicine, Kepler University Clinic, Linz, 2First Department of Internal Medicine, Ludwig Boltzmann-Institute of Osteology, Hanusch Hospital, Vienna, 3Paracelsus ...
Lang D, Pieringer H, Zwerina J
core  

Optimising the Diagnosis of Sesame Seed Allergy With the Basophil Activation Test

Allergy, EarlyView.
The basophil activation test (using the activation marker CD203c) was the only test able to both exclude and confirm sesame seed allergy with precision. A negative skin prick test to sesame extract or tahini and undetectable IgE to Ses i 1 could not rule out sesame seed allergy.
Ru‐Xin Foong, Irene Bartha, Holly Boyd, Andreina Marques‐Mejias, Suzana Radulovic, Marta Krawiec, Faye Harrison, Malak Eghleilib, Grammatiki Antoneria, Zainab Jama, Matthew Kwok, Vasco Claro, Cristian Ricci, Tom Marrs, Gideon Lack, George Du Toit, Alexandra F. Santos   +16 more
wiley   +1 more source

IgG4 glycosylation contributes to the pathogenesis of IgG4 Hashimoto’s thyroiditis via the complement pathway

European Thyroid Journal
Background: To explore whether IgG4 is involved in the pathogenesis of IgG4 HT. Methods: Serum TgAb IgG4 and TPOAb IgG4 were measured in IgG4 HT and non-IgG4 HT.
Chenxu Zhao, Zhiming Sun, Shuaihang Wang, Jixin Zhang, Jumei Liu, Lei Chen, Guizhi Lu, Yang Yu, Ying Gao   +8 more
doaj   +1 more source

Determinants of Immunoglobulin‐G N‐Glycan Patterns in the Aging General Population

Allergy, EarlyView.
The effect of demographic and lifestyle factors on IgG N‐glycosylation, which determines IgG's inflammatory response, remains poorly characterized. Aging, higher BMI, female sex, smoking, and heavy alcohol consumption are determinants of IgG N‐glycome patterns, which are indicative of inflammation. Women exhibit a distinct change in IgG N‐glycosylation
Samantha Leonard, Ralph Heijmans, Virgil A. S. H. Dalm, Silvan Licher, Jan Nouta, Steinar Gijze, David Falck, P. Martin van Hagen, Robin Peeters, Manfred Wuhrer, Layal Chaker   +10 more
wiley   +1 more source

Screening for IgG4-type anti-nuclear antibodies in IgG4-related disease. [PDF]

, 2015
[Background]Immunoglobulin (Ig) G4-related disease (IgG4-RD) is characterized by elevated serum IgG4 and infiltration of IgG4+ plasma cells into multiple organs. It is not known whether serum IgG4 is autoreactive in IgG4-RD.
Tsuneyo Mimori, Ohmura, Koichiro, Kitagori, Koji, Yoshitaka Imura, Mimori, Tsuneyo, Tsugumitsu Kandou, Daisuke Kawabata, Takao Fujii, Yoshifuji, Hajime, Hajime Yoshifuji, Kiyama, Kazuhiro, Koji Kitagori, Kazuhiro Kiyama, Hosono, Yuji, Ran Nakashima, Yuji Hosono, Fujii, Takao, Naoichiro Yukawa, Yukawa, Naoichiro, Kawabata, Daisuke, Imura, Yoshitaka, Nakashima, Ran, Koichiro Ohmura, Kandou, Tsugumitsu   +23 more
core   +1 more source

Kinetics of Antibody Responses and Effector Cell Sensitivity After High Dose Birch Extract Nasal Challenge

Allergy, EarlyView.
High‐dose birch‐extract nasal challenge induced synchronous peaks at 4 weeks in serum specific IgE (sIgE) and basophil sensitivity. Mast cell sensitivity via tSPT and sIgG1 and sIgG4 responses peaked later, at 6–8 weeks. Preseasonal allergen exposure attenuated seasonal sIgE increase and prevented further rise in tSPT sensitivity.
N. J. Campion, S. Villazala‐Merino, C. Morgenstern, L. Nemec, V. Stanek, A. Tu, M. Zghaebi, J. Toth, R. Fröschl, T. Perkmann, M. Bastl, K. Gangl, S. Schneider, H. Breiteneder, R. Ristl, M. Focke‐Tejkl, R. Valenta, V. Niederberger‐Leppin, J. Eckl‐Dorna   +18 more
wiley   +1 more source

IgE Antibody Function and Mast Cell Activation to Egg in Children Undergoing Baked and Loosely Cooked Egg Challenges

Allergy, EarlyView.
MAT is dependent on the presence of allergen‐specific IgE and can provide false‐negative results in allergic patients with low allergen‐specific IgE levels. MAT and BAT are moderately correlated. MAT can be used as a surrogate of BAT, when fresh blood is not available or in the case of patients with non‐releaser basophils.
Vikki Houghton, Vasco Claro, Nur Romli, Zainab Jama, Grammatiki Antoneria, Matthew Kwok, Alexandra F. Santos   +6 more
wiley   +1 more source