Results 141 to 150 of about 49,732 (222)

Model‐Enabled Knowledge Transfer Across Cell Lines, Culture Scales and Conditions

Biotechnology and Bioengineering, Volume 123, Issue 10, Page 2613-2628, October 2026.
ABSTRACT Mechanistic models are central to quantitative understanding and optimization of Chinese hamster ovary (CHO) cell culture processes, but their utility is often restricted by parameter sets calibrated for specific cell lines, scales, or operating conditions.
Luxi Yu, Antonio del Rio Chanona, Cleo Kontoravdi   +2 more
wiley   +1 more source

Intracranial inflammatory pseudotumour related to IgG4: A very rare case [PDF]

Caspian Journal of Internal Medicine
Background: Intracranial inflammatory pseudotumours (IPT) are rare entities that frequently lead to misdiagnosis with malignant lesions. The identification of these lesions is difficult, but important to avoid inadvertent iatrogenicity and to adjust ...
Ghassen Gader, Meissa Hamza, Ftima Zarraa, Ines Chelly, Ihsen Zammel, Mouna Rkhami, Mohamed Badri   +6 more
doaj  

Short‐Course Subcutaneous Immunotherapy With Mannan‐Conjugated Birch Pollen Allergoids: Consistent Clinical and Immunological Improvements

Clinical and Translational Allergy, Volume 16, Issue 10, October 2026.
ABSTRACT Background The mannan‐conjugated birch pollen polymerised allergoid EP‐088_T502 has previously been shown to reduce allergic symptoms and anti‐allergic medication use during the birch pollen season. This confirmatory phase III trial aimed to evaluate the efficacy, safety, tolerability, and immunologic effects of EP‐088_T502 administered as ...
Esther Raskopf, Sofia Passamera, Ludger Klimek, Oliver Pfaar, Christian Neuhof, Anna Rybachuk, Nadine Katzke, Hacer Sahin, Silke Allekotte, Ralph Mösges, Laura Day, José Luis Subiza, Miguel Casanovas, Mandy Cuevas, Sandra del Pozo   +14 more
wiley   +1 more source

Bioassays in Allergy: Technical Characteristics, Limitations, and Pathways to Clinical Implementation—An EAACI Position Paper

Clinical and Translational Allergy, Volume 16, Issue 10, October 2026.
ABSTRACT Bioassays offer functional readouts of immune responses through specific biomarkers, providing mechanistic insight beyond conventional serology. By capturing cellular activation, tissue‐level changes, and molecular signaling, they hold promise for refining allergy diagnosis, risk stratification, and treatment monitoring, contributing to ...
Cagatay Karaaslan, Oscar Palomares, Busra Kilic, Cristobalina Mayorga, Hans Jürgen Hoffmann, Bernadette Eberlein, Edward Knol, Ruben Fernandez‐Santamaria, Joana Vitte, Elena Izquierdo, Cristina Gomez‐Casado, Marina Perez‐Gordo, Araceli Diaz Perales, Maria M. Escribese   +13 more
wiley   +1 more source

Phase 1 dose escalation and expansion trial of the bispecific CD47 inhibitor and CD40 agonist Fc‐fusion protein SL‐172154 (SIRPα‐Fc‐CD40L) in patients with higher‐risk myelodysplastic syndrome or acute myeloid leukemia

Cancer, Volume 132, Issue 19, 1 October 2026.
Abstract Background This clinical trial sought to determine whether SL‐172154 could be combined safely and improve the efficacy of azacitidine (AZA) in patients with higher‐risk myelodysplastic syndrome (HR‐MDS) or acute myeloid leukemia (AML). Methods Dose escalation: doses of 1, 3, and 6 mg/kg SL‐172154 was evaluated as monotherapy or in combination ...
Naval G. Daver, Amer M. Zeidan, Anthony S. Stein, Joshua F. Zeidner, Keri Maher, Emily Curran, Dale Bixby, Wanxing Chai‐Ho, Maximilian Stahl, Karen W. L. Yee, Don Stevens, Sawa Ito, Jana Reynolds, Patrick Medd, Emma Searle, Andrew Sochacki, Mary Lynn Savoie, Steven Green, Kazunobu Kato, Robert Hernandez, Simon Metenou, Bo Ma, Lini Pandite, Taylor H. Schreiber, David A. Sallman   +24 more
wiley   +1 more source

Quantitative total serum IgG4 reporting in human paragonimiasis: a scoping review. [PDF]

Trop Med Health
Takahashi H, Yasuda T, Satake Y, Nagamatsu H, Hirose R, Toyama-Kosaka M, Ota S, Morikawa M, Kokubo-Tanaka M, Shinkai M.   +9 more
europepmc   +1 more source

Immune cells in the pathogenesis of abdominal aortic aneurysm: Roles, regulation and targeted interventions

Clinical and Translational Discovery, Volume 6, Issue 5, October 2026.
This review provides a comprehensive overview of how macrophages, neutrophils, T cells and other immune cells infiltrate the aortic wall, undergo phenotypic shifts and interact with one another in abdominal aortic aneurysm (AAA). Background Abdominal aortic aneurysm (AAA) is a lethal degenerative vascular disease with no approved clinical drugs. Immune
Junqi Peng, Hanqing Zhang, Yun Wu, Song Chen   +3 more
wiley   +1 more source

A case report: an unusual case of ulcerative intestinal IgG4-related disease with clinical features overlapping with probable intestinal Behcet's disease. [PDF]

BMC Gastroenterol
Zhan S, Yang J, Liang W, Huang H, Zhou Y.   +4 more
europepmc   +1 more source

A Retrospective Review of 1821 Cases of Eosinophilia in a Single‐Center Study in Eastern China

eJHaem, Volume 7, Issue 5, October 2026.
ABSTRACT Objective: Our study aims to explore the types of diseases that may cause eosinophilia and the changes in the disease spectrum of different degrees of eosinophilia. Methods We retrospectively analyzed patients who were admitted to the First Affiliated Hospital of Soochow University from July 1, 2023 to June 30, 2024, and had at least twice ...
Yanan Ma, Linlin Wang, Yuexin Cheng, Xiaofei Yang, Suning Chen   +4 more
wiley   +1 more source

Simultaneous Thyroid Eye Disease and IgG4-Related Orbital Disease in a Patient With Diabetes Mellitus: A Case Report. [PDF]

Am J Case Rep
Hayatulhaya B, Kashima T.
europepmc   +1 more source