Results 151 to 160 of about 49,732 (222)

Strategy for modular assembly of tetravalent, multispecific antibodies

Protein Science, Volume 35, Issue 10, October 2026.
Abstract Multispecific, multivalent antibodies (Abs) are a burgeoning class of drugs that dramatically expand the pharmacological repertoire beyond traditional therapeutic Abs. Here, we present a simple, modular approach to developing multispecific, multivalent Abs based on a Fab‐phage library with a single light chain.
Evan Mallette, Levi L. Blazer, Craig A. Hokanson, Chao Chen, Julia Garcia Perez, Alevtina Pavlenco, Lynda Ploder, Alexander U. Singer, Michael D. L. Suits, Sunil Bhakta, Jagath R. Junutula, Jarrett J. Adams, Sachdev S. Sidhu   +12 more
wiley   +1 more source

Transcriptomic associations and biomarkers in ANCA‑associated Glomerulonephritis and IgG4‑related Disease: A bioinformatics and machine learning study. [PDF]

PLoS One
Li X, Qiao Y.
europepmc   +1 more source

Drug‐Induced Liver Injury During Treatment With Tocilizumab: A Case Report of an Atypical Pattern Lesion

Pharmacology Research &Perspectives, Volume 14, Issue 5, October 2026.
ABSTRACT Tocilizumab is an interleukin‐6 (IL‐6) receptor antagonist indicated for various rheumatologic conditions. While hepatotoxicity is a recognized adverse effect, it predominantly manifests as hepatocellular injury. We report a rare case of drug‐induced liver injury (DILI) presenting with a cholestatic pattern and cholangitis features in a 75 ...
Louis‐Edmond Barbaro, Nouha Ben Othman, Delphine Viard, Fanny Rocher, Elliot Ewig, Raja Mroue, Claire Amigues, Alexandre O. Gérard   +7 more
wiley   +1 more source

Relationship between serum IgG4 levels and clinical activity of ophthalmopathy in Graves' disease. [PDF]

BMC Ophthalmol
Mengeş D, Yılmaz A, Doğan Ö, Önder F.   +3 more
europepmc   +1 more source

Immunoglobulin a Deficiency in Coeliac Disease: A Scoping Review

United European Gastroenterology Journal, Volume 14, Issue 8, October 2026.
ABSTRACT Coeliac disease (CeD) and immunoglobulin A deficiency (IgAD) frequently co‐occur and share a genetic background within the HLA‐DQ2 region. Although this has been known for decades, the underlying mechanisms linking the two conditions remain unclear.
Kristine Bech, Cæcilie Crawley, Rok Seon Choung, Joseph A. Murray, Steffen Husby   +4 more
wiley   +1 more source

Castleman disease and IgG4-related ophthalmic disease: Two of a kind. [PDF]

Indian J Ophthalmol
Hada M.
europepmc   +1 more source

Emerging Paediatric Uses of Dupilumab Beyond Approvals

Clinical &Experimental Allergy, Volume 56, Issue 10, Page 1162-1176, October 2026.
Dupilumab, through IL‐4Rα blockade, shows promising efficacy beyond approved indications in paediatric diseases driven by T2 inflammation. Emerging evidence—mainly from small studies—supports improvements in disease severity and quality of life, highlighting its potential as a targeted, steroid‐sparing therapy while underscoring the need for ...
Simone Foti Randazzese, Anna Calamita, Diletta D'Angelo, Alessia Marseglia, Esther Mesa Lombardero, Sara Pedersoli, Micol Tedeschi, Mara De Amici, Sara Manti, Valeria Brazzelli, Amelia Licari, Gian Luigi Marseglia   +11 more
wiley   +1 more source

Efficacy and safety of mycophenolate mofetil in preventing relapse of IgG4-related disease with re-elevation of serum IgG4 level during maintenance therapy: a protocol for a multicentre, randomised, double-blind, placebo-controlled study in China. [PDF]

BMJ Open
Zhang J, Nie Y, Peng L, Fei Y, Liu Y, Dong L, Kong X, Fu M, Zhang X, Liu C, Chen Y, Li M, Zhou J, Zhang W.   +13 more
europepmc   +1 more source

Extranodal Marginal Zone Lymphoma: Integrating Etiology, Microenvironment, and Genetics Into Clinical Decision‐Making

European Journal of Haematology, Volume 117, Issue 4, Page 849-863, October 2026.
ABSTRACT Extranodal marginal zone lymphoma (EMZL) represents a unique paradigm among indolent B‐cell neoplasms, in which lymphomagenesis is frequently driven by chronic antigenic stimulation within tissue‐specific microenvironments. Persistent infectious or autoimmune triggers promote the development of ectopic lymphoid tissue and sustain B‐cell ...
Mamdouh Skafi, Santino Caserta, Enrica Antonia Martino, Ernesto Vigna, Antonella Bruzzese, Nicola Amodio, Marco Fiorillo, Eugenio Lucia, Graziella D'Arrigo, Virginia Olivito, Caterina Labanca, Francesco Mendicino, Maria Eugenia Alvaro, Giovanni Tripepi, Fortunato Morabito, Massimo Gentile   +15 more
wiley   +1 more source

Immunoglobulin G4 (IgG4)-Related Lung Disease Mimicking Pulmonary Malignancy: A Case Report With Histopathological Characterisation and Review of Diagnostic Criteria. [PDF]

Cureus
Das S, Shaikh M, Priya S, Khan S.
europepmc   +1 more source