Results 181 to 190 of about 46,091 (305)

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, Volume 13, Issue 35, 24 June 2026.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Cornea biomechanics and biometric evaluations in immunoglobulin G4-related ophthalmic disease. [PDF]

PLoS One
Lai KKH, Aljufairi FMAA, Sebastian JU, Liao X, Chen W, Hu Z, Wei Y, Jia R, Wah C, Cheng ACO, Chin JKY, Kuk AK, Kwong CH, Yip NKF, Lam W, Li KKW, Yang N, Yip WWK, Young AL, Chan E, Ko CKL, Chan CKM, Yuen HKL, Chen LJ, Tham CCY, Pang CP, Chong KKL.   +26 more
europepmc   +1 more source

Selective Targeting of Immune Checkpoints HLA‐G and CD47 Using Novel Dual Signaling Protein DSP216 Promotes Innate Anticancer Immunity

Advanced Science, Volume 13, Issue 35, 24 June 2026.
The inhibitory immune checkpoints HLA‐G and CD47 are expressed on certain tumor types and inhibit immune cells in the tumor microenvironment. DSP216 binds specifically to cancer cells expressing both HLA‐G and CD47, and blocks their inhibitory signaling.
Lisa J. Jacob, Liat Tamir, Mufeed Abdeen, Ami Tamir, Alexandra Aronin, Itai Bloch, Roy Kahn, Iris Pecker, Mark Tykocinski, Gerwin Huls, Yaron Pereg, Ayelet Chajut, Edwin Bremer   +12 more
wiley   +1 more source

IgG4-Related Lung Disease Presenting as an Indeterminate Pulmonary Mass in a Young Woman With Prior Tuberculosis: A Case Report. [PDF]

Cureus
Thevan S, Sathiamurthy N, Retna Pandian BD.   +2 more
europepmc   +1 more source

Advances in Cancer Immunotherapy for Solid Tumors

Advanced Science, Volume 13, Issue 35, 24 June 2026.
Cancer immunotherapy for solid tumors is rapidly evolving beyond classical checkpoint blockade toward more precise strategies. Emerging checkpoint targets, bispecific antibodies, antibody–drug conjugate combinations, personalized vaccines, cellular therapies, and engineered cytokines are expanding therapeutic possibilities, while biomarker‐guided ...
Shira Gabizon‐Peretz, Harriet M. Kluger   +1 more
wiley   +1 more source

Cocaine-Induced Plasma Cell Dermatomucositis (CI-PCDM): Clinical and Histopathological Features of a UK Cohort. [PDF]

Head Neck Pathol
Thermos G, Morrison E, Cuddy L, Ghumra W, Paraschou K, Brophy C, Takhar A, Tikka T, Tamiolakis P, Khirwadkar N.   +9 more
europepmc   +1 more source

Case Report: IgG4-rich tubulointerstitial inflammation in MPO-ANCA-associated glomerulonephritis: a case-based review. [PDF]

Front Immunol
Qiu S, Li S, Jin M, Chen Y, Chen S.
europepmc   +1 more source

Detection of Anti‐Infliximab and Anti‐Adalimumab Antibodies Below Manufacture's Threshold in a TDM Cohort Using Signal‐to‐Noise Ratio

Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 1, July 2026.
Lise Pedersen
wiley   +1 more source

IgG4-related kidney disease presenting as severe renal failure: Diagnostic challenges of a multimodality imaging approach. [PDF]

Radiol Case Rep
Montatore M, Guerra FS, Eusebi L, Santarelli S, Ramazzotti V, Mazzucchelli R, Masino F, Mannatrizio D, Testini V, Guglielmi G.   +9 more
europepmc   +1 more source

A 50‐year‐old man with a 12‐year history of extensive pachymeningeal thickening

Brain Pathology, Volume 36, Issue 4, July 2026.
Alyssa M. Lee, Siddhartha Gaddamanugu, Kathyrn L. Eschbacher, Aishwarya Ravindran   +3 more
wiley   +1 more source